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Dispensing nozzle for automatic analyzer, automatic analyzer equipped with the nozzle, and method for producing dispensing nozzle for automatic analyzer

An automatic analysis device and dispensing nozzle technology, applied in the direction of analysis materials, instruments, etc., can solve problems such as increased environmental load, large amount of waste, and difficulty in forming fine structures, so as to reduce operating costs, achieve microquantification, and improve cleaning. degree of effect

Inactive Publication Date: 2013-02-13
HITACHI HIGH-TECH CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is difficult to form a fine structure in a nozzle that can be handled freely from the viewpoint of strength and processing accuracy.
In addition, there is also a problem that the use of disposable nozzles generates a large amount of waste and increases the environmental load

Method used

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  • Dispensing nozzle for automatic analyzer, automatic analyzer equipped with the nozzle, and method for producing dispensing nozzle for automatic analyzer
  • Dispensing nozzle for automatic analyzer, automatic analyzer equipped with the nozzle, and method for producing dispensing nozzle for automatic analyzer
  • Dispensing nozzle for automatic analyzer, automatic analyzer equipped with the nozzle, and method for producing dispensing nozzle for automatic analyzer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1）

[0048] (device configuration)

[0049] figure 1 A configuration example of the automatic analyzer according to the present invention is shown. The sample storage unit mechanism 1 is arranged in the automatic analyzer. One or more sample containers 25 are arranged in the sample storage unit mechanism 1 . figure 1 The illustrated sample storage unit mechanism 1 is an example of a so-called sample tray mechanism in which a sample container 25 is detachably mounted on a tray-shaped main body. In fact, other mechanisms such as sample racks or sample holders that are generally used in automatic analyzers may be used in the sample storage unit mechanism 1 .

[0050] The sample referred to here refers to the test solution used for the reaction in the reaction container, and may be a collected sample stock solution, or may be a solution processed by dilution, pretreatment, etc. of the stock solution. The sample in the sample container 25 is extracted by the sample dispensing nozzle...

experiment example 1）

[0084] First, in order to improve the reliability of the analysis, the effect was verified using a flat substrate. The size of the substrate used was 30 mm x 30 mm x 0.5 mm, and the measurement surface used for effect verification was a surface of 30 mm x 30 mm.

[0085] Figure 5 Indicates the flow of the surface treatment process.

[0086] Process 1. Cleaning of stainless steel

[0087] The SUS304 substrate was ultrasonically cleaned with 0.1% NaOH aqueous solution and ethanol for 15 minutes, and washed with water. After that, the SUS304 substrate was dried by blowing nitrogen.

[0088] Step 2. Immersing in a solution of a phosphonic acid derivative

[0089] The SUS304 substrate cleaned in step 1 was immersed in the solution of the phosphonic acid derivative for 24 hours. Thereafter, it was taken out from the solution, and after washing with a solvent, it was washed with pure water. After that, the SUS304 substrate was dried by blowing nitrogen.

[0090] The validation ...

experiment example 2）

[0092] In the case of the aforementioned Experimental Example 1, the surface treatment was performed by a procedure of adsorbing a phosphonic acid derivative in a one-stage reaction. In the case of Experimental Example 2, a method of surface treatment by a multi-step reaction will be described.

[0093] Figure 7 Indicates the flow of the surface treatment process. This surface treatment step is roughly composed of two treatment steps. The first is a step of coating the surface of stainless steel with a phosphonic acid derivative having a reactive functional group at the end, and the second is a step of immobilizing a molecule having a desired function to the reactive functional group.

[0094] In the case of this experimental example, first, a method of first immobilizing a phosphonic acid having a carboxyl group at the end on the nozzle surface, and then reacting and activating the carboxyl group will be described. In addition, polyethylene glycol (PEG) derivatives were u...

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Abstract

The purpose of the present invention is to provide an automatic analyzer for analyzing samples such as urine and blood, wherein analytical values are not affected by the dispensing nozzle which is repeatedly used. In order to achieve the purpose, the surface of the dispensing nozzle is caused to chemically adsorb a phosphonic acid derivative or a phosphoric acid derivative. Consequently, a molecular layer, which inhibits adsorption of a biopolymer or adhesion of a sample itself, is formed on the nozzle surface, so that the dispensing nozzle is prevented from affecting precision of analysis.

Description

technical field [0001] The present invention relates to a dispensing nozzle for an automatic analyzer, an automatic analyzer equipped with the nozzle, and a method for manufacturing a dispensing nozzle for an automatic analyzer. Background technique [0002] In clinical examinations for medical diagnosis, biochemical analysis and immunological analysis of proteins, sugars, lipids, enzymes, hormones, inorganic ions, and disease markers in biological samples such as blood or urine are performed. In clinical examinations, it is necessary to process a plurality of examination items with high reliability and speed. Therefore, the majority of the analysis is performed using automated analysis equipment. [0003] As an automatic analyzer, for example, a biochemical analyzer is known that uses a reaction solution obtained by mixing and reacting a desired reagent with a sample such as serum or urine as an analysis object, and performs biochemical analysis by measuring the absorbance...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N35/10
CPCG01N35/1002G01N35/10G01N35/1004
Inventor 野岛彰纮谷口伸一石泽宏明
Owner HITACHI HIGH-TECH CORP
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