Key protein predicating method based on priori knowledge and network topology characteristics

Abstract

The invention discloses a key protein predicating method based on priori knowledge and network topology characteristics. Based on the analysis of the topological relation between known key proteins, the close relation between key proteins is found; edge clustering coefficients are taken as parameters for assessing the close degree of two key proteins; and parts of known key proteins and the shared-clustering coefficients of neighbor nodes and the known key proteins are utilized for predicating new key proteins. The key protein predicating method is simple to implement and unknown key proteins can be accurately predicated just according to PPI (protein-protein interaction) information and information of parts of known key proteins, the method is applicable to not only non-weighted PPI networks but also weighted PPI networks, and the problems such as high cost and time wasting of a chemical experiment method are solved.

Description

technical field [0001] The invention relates to the field of prediction of key proteins based on the network level, in particular to a method for predicting new key proteins based on some known key proteins and topological properties of biological networks. Background technique [0002] Protein is an essential component of all cell and tissue structures. It is the executor of physiological functions and the embodiment of life phenomena. Different proteins perform different physiological functions. Among them, there are some proteins whose removal through gene knockout mutation will cause the loss of function of the relevant protein complex and cause the organism to fail to survive. These proteins are called key proteins. Effective prediction of key proteins is of great significance to the study of cell growth regulation processes, and is also of great value to the study of pathogenic biology and drug design. [0003] In the field of biology, experimental methods such as ge...

AI Technical Summary

Problems solved by technology

[0009] The technical problem to be solved by the present invention is to provide a simple method for predicting key proteins based on prior knowledge and network topology characteristics in view of the deficiencies in the prior art. Know the topological closeness of key proteins to predict the criticality of other proteins, solve the problems of expensive and time-consuming chemical experiment methods, and improve the accuracy of key protein prediction

Images