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Use of L-citrulline in preparation of anti-gastric ulcer drugs

A technology of citrulline and gastric ulcer, which is applied in the field of pharmacy to achieve the effect of strong therapeutic effect, good pharmacological effect and good medicinal prospect

Inactive Publication Date: 2013-03-20
XUZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there is no report about the anti-gastric ulcer effect of L-citrulline and the composition of L-citrulline and conventional anti-gastric ulcer drugs

Method used

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  • Use of L-citrulline in preparation of anti-gastric ulcer drugs
  • Use of L-citrulline in preparation of anti-gastric ulcer drugs
  • Use of L-citrulline in preparation of anti-gastric ulcer drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1, the preventive effect of L-citrulline on absolute ethanol type gastric ulcer in rats

[0023] 1 Materials and methods

[0024] 1.1 Experimental animals SD strain rats, 8 weeks old, male, weighing 180-200 g, were provided by the Experimental Animal Center of Xuzhou Medical College. Certificate number: SCXK (Su) 2003-0003. Fasting 24h before the experiment, drinking water freely, room temperature (23±2)℃.

[0025] 1.2 Drugs and reagents L-citrulline was purchased from Ningbo Zhenhai Haide Biochemical Technology Co., Ltd., cimetidine was produced by Shandong Fangming Pharmaceutical Co., Ltd., and biochemical kits were purchased from Nanjing Jiancheng Bioengineering Co., Ltd.

[0026] 1.3 Method

[0027] 1.3.1 Modeling and experimental treatment

[0028] 48 healthy male SD rats were randomly divided into normal control group, model group, cimetidine group (240mg / kg), L-citrulline low, medium and high dose (100, 300, 600mg / kg) groups 8 were randomly selected ...

Embodiment 2

[0044] Embodiment 2, the therapeutic effect of L-citrulline on rat glacial acetic acid type gastric ulcer

[0045] 1 Materials and methods

[0046] 1.1 Experimental animals, medicines and reagents are the same as in Example 1.

[0047] 1.2 Experimental method

[0048] 1.2.1 Modeling and experimental treatment

[0049] Take 48 SD rats, male, weighing 180-200g, fasting for 24 hours, drinking water freely, and anesthetized by intraperitoneal injection of 3% sodium pentobarbital. Press the tube on the serosa surface about 5mm below the lesser curvature notch of the gastric forearm, inject 0.1ml of 100% glacial acetic acid into the glass tube for 1min, blot dry the glacial acetic acid in the glass tube with a fine cotton swab, remove the glass tube, Gently scrub twice with a cotton swab of 0.9% sodium chloride solution, then cover the acetic acid smeared surface with omentum, put the stomach into the abdomen, and suture the abdominal wall. In the sham operation control group, t...

Embodiment 3

[0063] Embodiment 3, the therapeutic effect of L-citrulline on aspirin-type gastric ulcer in rats

[0064] 1 Materials and methods

[0065] 1.1 Experimental animals, medicines and reagents are the same as in Example 1

[0066] 1.2 Experimental method

[0067] 1.2.1 Modeling and experimental treatment

[0068] Get 48 healthy SD rats, male, are randomly divided into normal control group, model group, cimetidine group (240mg / kg), L-citrulline low, medium and high dose (100,300,600mg / kg) kg) group, 8 animals were randomly selected from each group. The normal control group was only given normal saline without surgery, and the other groups were given aspirin (300mg / kg) by intragastric administration once, and then drug treatment was given respectively. On the first day after surgery, the rats were sacrificed after taking blood from the abdominal aorta. The stomach was taken out, cut open along the greater curvature of the stomach, rinsed with ice saline, and the degree of gastri...

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Abstract

The present invention relates to a new use of L-citrulline, and in particular relates to the use of L-citrulline in the preparation of anti-gastric ulcer drugs, belonging to the technical field of pharmacology. According to the present invention, via the establishment of experimental gastric ulcer models in rats, protective effects of L-citrulline on ethanol, acetic acid or aspirin-induced gastric ulcers in rat are studied. The L-citrulline is separately combined with an effective dose of a conventional anti-ulcer drug cimetidine, ranitidine, or sucralfate to compose a pharmaceutical composition, protective effect of the pharmaceutical composition on the ethanol, acetic acid or aspirin-induced gastric ulcers in rat is studied, and it is found that the protective effect is more significant. In addition, the pharmaceutical composition that comprises L-citrulline and an effective dose of a conventional anti-ulcer drug as active ingredients and appropriate excipients, can be prepared to be pharmaceutically acceptable dosage forms, including tablets, granules, capsules, oral solution, sustained-release formulations and nano-formulations.

Description

technical field [0001] The invention relates to a new application of L-citrulline, in particular to an application of L-citrulline in the preparation of anti-gastric ulcer drugs, which belongs to the technical field of pharmacy. Background technique [0002] Gastric ulcers are a common condition, affecting about 10% of the population at some point in their lifetime. Gastric ulcer is a multifactorial disease with complex etiology, and the real cause of gastric ulcer in daily life has not yet been clarified. With the improvement of people's living standards and the prolongation of life expectancy, people's awareness of the prevention and treatment of gastric ulcer is constantly increasing. Therefore, gastric ulcer is becoming one of the important research topics in the medical circles all over the world. The Western medicine treatment of gastric ulcer is mainly symptomatic treatment, and gastrointestinal antispasmodic drugs are mostly used. Although the effect is rapid and r...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61K31/4164A61K31/341A61K31/7024A61P1/04
Inventor 刘毅印晓星田霞缑灵山庄雪梅郑友广张玲刘玲
Owner XUZHOU MEDICAL COLLEGE
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