Use of L-citrulline in preparation of anti-gastric ulcer drugs
A technology of citrulline and gastric ulcer, which is applied in the field of pharmacy to achieve the effect of strong therapeutic effect, good pharmacological effect and good medicinal prospect
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[0022] Example 1. Preventive effect of L-citrulline on ethanol-type gastric ulcer in rats
[0023] 1 Materials and methods
[0024] 1.1 Experimental animal SD rats are 8 weeks old, male, weighing 180-200g, provided by the Experimental Animal Center of Xuzhou Medical College. Certificate number: SCXK (Su) 2003-0003. Fasting 24h before the experiment, drinking water freely, room temperature (23±2)℃.
[0025] 1.2 Medicines and reagents L-citrulline was purchased from Ningbo Zhenhai Hyde Biochemical Technology Co., Ltd., cimetidine was produced by Shan Dongfang Ming Pharmaceutical Co., Ltd., and the biochemical kit was purchased from Nanjing Jiancheng Biological Engineering Co., Ltd.
[0026] 1.3 method
[0027] 1.3.1 Modeling and experimental treatment
[0028] 48 healthy male SD rats were randomly divided into normal control group, model group, cimetidine group (240mg / kg), L-citrulline low, medium and high dose (100, 300, 600mg / kg) groups , 8 randomly selected from each group. The norm...
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[0044] Example 2. The therapeutic effect of L-citrulline on glacial acetic acid gastric ulcer in rats
[0045] 1 Materials and methods
[0046] 1.1 Experimental animals, drugs and reagents are the same as in Example 1.
[0047] 1.2 Experimental method
[0048] 1.2.1 Modeling and experimental treatment
[0049] Take 48 SD rats, male, weighing 180-200g, fasting for 24 hours, drinking freely, and anesthetized by intraperitoneal injection of 3% pentobarbital sodium. Open the abdominal cavity and gently pull out the stomach to form a glass circle with an inner diameter of 4 mm. Press the tube on the serosal surface about 5mm below the gastric forearm notch, and inject 0.1ml of 100% glacial acetic acid into the glass tube for 1 min. Use a fine cotton swab to absorb the glacial acetic acid in the glass tube and remove the glass tube. Wipe gently with a cotton swab of 0.9% sodium chloride solution twice, then cover the acetic acid coating surface with omentum, put the stomach into the abdomen...
Example Embodiment
[0063] Example 3. The therapeutic effect of L-citrulline on aspirin-type gastric ulcer in rats
[0064] 1 Materials and methods
[0065] 1.1 Experimental animals, drugs and reagents are the same as in Example 1
[0066] 1.2 Experimental method
[0067] 1.2.1 Modeling and experimental treatment
[0068] Take 48 healthy SD rats, males, and randomly divide them into normal control group, model group, cimetidine group (240mg / kg), low, medium and high doses of L-citrulline (100, 300, 600mg / kg) group, 8 animals were randomly selected from each group. The normal control group was given normal saline without surgery, the other groups were given aspirin (300mg / kg) once by gavage, and then they were given medications. The model group was given normal saline for 5 days continuously, once a day, and the administration was completed On the first day afterwards, the rats were sacrificed after blood collection from the abdominal aorta, the stomach was taken out, the stomach was cut along the great...
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