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Application of Acanthopanax obovatus Hoo in peptic ulcer resistance and medicine prepared from Acanthopanax obovatus Hoo

An anti-digestion technology of Acanthopanax ovalifolia, applied in the direction of medical preparations containing active ingredients, applications, digestive system, etc., can solve the problems of not suitable for long-term medication, treating the symptoms but not the root cause, and combined medication, etc., to achieve the material basis of action And the mechanism of action is clear, the effect is quick, and the effect of relieving pain symptoms

Active Publication Date: 2013-03-27
陕西中药研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many kinds of drugs for the treatment of peptic ulcer and chronic gastritis, but most of them have a single effect and need to be combined with drugs, and they treat the symptoms but not the root cause, and have relatively large side effects, so they are not suitable for long-term medication

Method used

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  • Application of Acanthopanax obovatus Hoo in peptic ulcer resistance and medicine prepared from Acanthopanax obovatus Hoo
  • Application of Acanthopanax obovatus Hoo in peptic ulcer resistance and medicine prepared from Acanthopanax obovatus Hoo
  • Application of Acanthopanax obovatus Hoo in peptic ulcer resistance and medicine prepared from Acanthopanax obovatus Hoo

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1 The preparation of the water extract of Acanthopanax ovalifolia:

[0041] Take the Chinese herbal medicine, crush it, add water and decoct three times, add 10 times the amount of the medicinal material for the first time and decoct for 1 hour, add 8 times the amount of water for the second time and decoct for 1 hour, and add 8 times the amount of water for the third time Decoct for 0.5 hours, combine the decoction liquid, filter, and concentrate the filtrate under reduced pressure to a clear paste with a relative density of 1.30 to 1.35 (measured at 55°C), dry under vacuum and reduce pressure, and pulverize into fine powder to obtain Acanthopanax ovale with water. dry powder.

Embodiment 2

[0042] The preparation of embodiment 2 obversia acanthus ethanol extract

[0043] Take Acanthopanax ovata medicinal material, crush it, add 10 times the mass of 60% ethanol to heat and reflux extraction, each time for 1 hour, collect the extract, let it stand, filter, recover ethanol under reduced pressure and concentrate to a relative density of 1.12 (50 ~60°C), spray-dried to obtain the ethanol extract of Acanthopanax ovalifolia.

Embodiment 3

[0044] Example 3 Preparation of the extract of Acanthus ovalifolia with water extraction and alcohol precipitation

[0045]Take the Argonaus ovata medicinal material, crush it, add water to decoct twice, add 10 times the amount of water to decoct for 1 hour for the first time, add 8 times the amount of water to decoct for 0.5 hours for the second time, combine the decoction liquid, filter, Concentrate under reduced pressure to a relative density of 1.25-1.30 (55°C), let it cool, add ethanol to make the alcohol content reach 65%, let stand for 24 hours, take the supernatant to recover ethanol under reduced pressure and concentrate to a relative density of 1.30-1.35 (measured at 55° C.), dried under vacuum and reduced pressure, and pulverized to obtain dry cream powder of the extract of Acanthopanax ovalifolia plus water extraction and alcohol precipitation.

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Abstract

The invention discloses application of Acanthopanax obovatus Hoo in peptic ulcer resistance and a medicine prepared from the Acanthopanax obovatus Hoo, particularly peptic ulcer resistant effect of an Acanthopanax obovatus Hoo extractive. After the extractive is obtained by taking the Acanthopanax obovatus Hoo as the raw material, the result shows that the extractive is capable of effectively protecting and preventing gastric ulcer and duodenal ulcer, repairing gastrointestinal mucosa, promoting Gastrointestinal mucosa ulcer healing and improving gastrointestinal functions; and the Acanthopanax obovatus Hoo extractive has pharmacological actions of resisting stress ulcer, hydrochloric ulcer, indometacin-ethanol ulcer and pylorus ligation ulcer in a dose dependent manner, has obvious abirritation, has better therapeutic action on digestive diseases such as gastric ulcer and the like, and is a safe health-care and curative medicine applied to digestive systems of crowds suffering from gastric ulcer, duodenal ulcer, chronic gastritis, disorders of digestion and the like.

Description

technical field [0001] The invention belongs to the technical field of anti-peptic ulcer medicines, and relates to the anti-peptic ulcer application of Acanthopanax ovalifera and the prepared medicine. Background technique [0002] Peptic ulcer refers to the tissue damage of the gastrointestinal mucosa beyond the muscularis mucosa caused by the digestion of gastric digestive juice itself. It can occur in any part of the digestive tract, among which the stomach and duodenum are the most common, namely gastric ulcer and ten duodenal ulcer. This disease is a kind of common disease, frequently-occurring disease, and the total incidence rate accounts for about 10%~12% of the population. Ulcers can be induced by emotional stress, various psychological factors, bad eating habits and drug stimulation. The main manifestations are regular pain and discomfort in the upper abdomen, acid regurgitation, nausea and vomiting, loss of appetite, weight loss and other symptoms. cancerous. ...

Claims

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Application Information

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IPC IPC(8): A61K36/254A23L1/29A61P1/04A23L33/00
Inventor 朱爱华同卓斌周新民
Owner 陕西中药研究所
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