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Compound sulfamonomethoxine sodium solution and preparation method thereof

A technology of methoxine sodium and compound sulfa, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, drug delivery and other directions, can solve the problems that bacteria are prone to drug resistance and is rarely used alone, etc., and achieves stable properties, The effect of convenient administration and resource saving

Active Publication Date: 2013-04-03
JIANGSU HFQ BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Trimethoprim is a broad-spectrum antibacterial drug, the antibacterial spectrum is similar to that of sulfa drugs, and it can inhibit dihydrofolate reductase, but bacteria are prone to drug resistance, so it is rarely used alone

Method used

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preparation example Construction

[0023] The preparation method of compound recipe sulfamethoxine sodium solution of the present invention, it comprises the steps:

[0024] (1) Put the organic solvent in a beaker, heat it in a water bath at 60-70 degrees Celsius, pour the weighed sulfamethoxine sodium and trimethoprim into it, and keep stirring to clarify;

[0025] (2) Take another beaker, add an appropriate amount of water, preheat it in a water bath at 30-70 degrees Celsius, add antioxidants and complexing agents, and keep stirring to make it clear;

[0026] (3) Slowly add the solution in (2) to the solution in (1), and stir continuously to mix evenly to obtain a clear solution;

[0027] (4) After cooling, add the remaining amount of water to the solution obtained in (3), and set the volume to 100ml.

[0028] (5) Adjust the pH to 9.5-11.5 with sodium hydroxide solution.

[0029] In the present invention, the prepared compound sulfamethoxine sodium solution is sterilized by circulating steam at 120 degrees ...

Embodiment 1

[0032] Sulfamethoxine sodium 5g, trimethoprim 1g, organic solvent 25ml, antioxidant 0.1g, metal complex 0.1g; wherein, the organic solvent is a solution obtained by mixing propylene glycol and benzyl alcohol according to 3:2 , the antioxidant is sodium sulfite, and the complex is disodium edetate; the specific steps are as follows:

[0033] (1) Put the organic solvent in a beaker, heat it in a water bath at 60-70 degrees Celsius, pour the weighed sulfamethoxine sodium and trimethoprim into it, and keep stirring to clarify;

[0034] (2) Take another beaker, add an appropriate amount of water, preheat it in a water bath at 30-70 degrees Celsius, add antioxidants and complexing agents, and keep stirring to make it clear;

[0035] (3) Slowly add the solution in (2) to the solution in (1), and stir continuously to mix evenly to obtain a clear solution;

[0036] (4) After cooling, add the remaining amount of water to the solution obtained in (3), and set the volume to 100ml.

[00...

Embodiment 2

[0040] Sulfamethoxine sodium 10g, trimethoprim 2g, organic solvent 50ml, antioxidant 0.2g, metal complex 0.2g; wherein, the organic solvent is a solution obtained by mixing propylene glycol and benzyl alcohol according to 4:1 , the antioxidant is sodium bisulfite, and the complex is disodium edetate; the specific steps are as follows:

[0041] (1) Put the organic solvent in a beaker, heat it in a water bath at 60-70 degrees Celsius, pour the weighed sulfamethoxine sodium and trimethoprim into it, and keep stirring to clarify;

[0042] (2) Take another beaker, add an appropriate amount of water, preheat it in a water bath at 30-70 degrees Celsius, add antioxidants and complexing agents, and keep stirring to make it clear;

[0043] (3) Slowly add the solution in (2) to the solution in (1), and stir continuously to mix evenly to obtain a clear solution;

[0044] (4) After cooling, add the remaining amount of water to the solution obtained in (3), and set the volume to 100ml.

...

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PUM

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Abstract

The invention aims to disclose a compound sulfamonomethoxine sodium solution and a preparation method of the compound sulfamonomethoxine sodium solution. The compound sulfamonomethoxine sodium solution comprises 100ml of the following components: 5-20g of sulfamonomethoxine sodium, 1-5g of trimethoprim, 20-70ml of an organic solvent, 0.1-0.5g of an antioxidant and 0.1-0.5g of a metal complex. Compared with an injection liquid, the prepared compound sulfamonomethoxine sodium solution has the advantages of convenience for administration, resource economization, wide application, strong product activity, high bioavailability, stable efficacy, obvious effect, stable shape and properties, slow degradation of main drugs, capability of continuously keeping bioactivity and the like, and thus the aim of the invention is realized.

Description

technical field [0001] The invention relates to a solution and a preparation method thereof, in particular to a compound sulfamethoxine sodium solution for veterinary treatment of parasitic diseases and a preparation method thereof. Background technique [0002] Sulfamethoxine sodium is a relatively new generation of long-acting sulfonamides, and it ranks first among sulfonamides in terms of antibacterial effect. It has dual pharmacological effects: it can be both antibacterial and antiprotozoal, and has a strong antibacterial effect on Gram-positive bacteria and some negative bacteria, such as: streptococcus, pneumococcus, salmonella, staphylococcus, bacillus malleolus, Pakistan Sensitive to bacillus, Brucella, Klebsiella pneumoniae, Proteus, Shigella, Listeria, Actinobacillus, Spirochelia hyodysenteriae, etc. Antiprotozoa: This product is effective against leukocyte protozoa, coccidia, and toxoplasma in chickens sensitive. Growth-promoting effect, added in small doses, h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/635A61K31/505A61K9/08A61P31/04
Inventor 龙谭
Owner JIANGSU HFQ BIO TECH CO LTD
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