Preparation method of detoxicating tablet of cow-bezoar

A technology of Niuhuangjiedu tablets and Scutellaria baicalensis, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, plant raw materials, etc., can solve the problems of long disintegration time and low bioavailability of Niuhuangjiedu tablets, and shorten the heating time , high content of active ingredients, and the effect of reducing the amount of production

Active Publication Date: 2013-04-03
ZHENGZHOU RUILONG PHARMA
View PDF2 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Chinese patent (publication number: CN 1733084A) discloses a heat-clearing and detoxifying traditional Chinese medicine preparation and its preparation method. Disadvantages, but no clear solutions to toxicity and productivity issues

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of detoxicating tablet of cow-bezoar

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Take the rhubarb powder that has been sterilized and passed through a 100-mesh sieve, and the borneol powder and bezoar powder that have passed through a 80-mesh sieve respectively;

[0023] (2) Take the realgar, grind it with water to get a 0.2kg / L slurry, take the fine-grained slurry, centrifuge and freeze-dry to get the realgar powder for later use;

[0024] (3) Add bellflower, licorice, and gypsum into the extraction tank, add 8 times the amount of water, heat and boil, stop heating for 3 to 5 minutes, add skullcap, decoct for 2 hours, filter, add 6 times the amount of warm water to the filter residue and decoct After 2 hours, filter, combine the two decoctions and place them in a double-effect energy-saving concentrator, and concentrate the filtrate to an extract with a relative density of 1.19 at 77°C for later use;

[0025] (4) Put the rhubarb powder and realgar powder obtained in steps (1) and (2) in the container of the boiling drying granulator, start the ...

Embodiment 2

[0030] (1) Take the rhubarb powder that has been sterilized and passed through a 120-mesh sieve, and the borneol powder and bezoar powder that have passed through a 60-mesh sieve respectively;

[0031] (2) Take the realgar, grind it with water to get a 0.25kg / L slurry, take the fine-grained slurry, centrifuge and freeze-dry to get the realgar powder for later use;

[0032] (3) Add bellflower, licorice, and gypsum into the extraction tank, add 7 times the amount of water, heat and boil, stop heating for 3 to 5 minutes, add skullcap, decoct for 1.5 hours, filter, add 5 times the amount of warm water to the filter residue and decoct After 1.5 hours, filter, combine the two decoctions and place them in a double-effect energy-saving concentrator, and concentrate the filtrate to an extract with a relative density of 1.20 at 80°C for later use;

[0033] (4) Put the rhubarb powder and realgar powder obtained in steps (1) and (2) in the container of the boiling drying granulator, start...

Embodiment 3

[0038] (1) Take the rhubarb powder that has been sterilized and passed through a 100-mesh sieve, and the borneol powder and bezoar powder that have passed through a 100-mesh sieve respectively;

[0039] (2) Take the realgar, grind it with water to get a 0.3kg / L slurry, take the fine-grained slurry, centrifuge and freeze-dry to get the realgar powder for later use;

[0040] (3) Add bellflower, licorice, and gypsum into the extraction tank, add 9 times the amount of water, heat to boil, stop heating for 3 to 5 minutes, add skullcap, decoct for 2.5 hours, filter, add 7 times the amount of warm water to the filter residue and decoct After 2.5 hours, filter, combine the two decoctions and place them in a double-effect energy-saving concentrator, and concentrate the filtrate to an extract with a relative density of 1.21 at 83°C for later use;

[0041] (4) Put the rhubarb powder and realgar powder obtained in steps (1) and (2) in the container of the boiling drying granulator, start ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a preparation method of a detoxicating tablet of cow-bezoar, and belongs to the technical field of Chinese medicament preparation. The method is reasonable in process flow setting, can be used for remarkably improving the production efficiency of the detoxicating tablet of cow-bezoar and reducing the heated time of realgar in the granulating process by adopting a one-step granulation method. The granulation efficiency is remarkably improved by increasing the density of extracted concentrate and spray liquid, so that the production efficiency of the detoxicating tablet of cow-bezoar is greatly improved, and the drying time in the granulating step is effectively reduced. According to the preparation method, the heated temperature of realgar and realgar-containing component in the drying process can be reduced, and the transformation amount of realgar to arsenic trioxide is effectively avoided, so that the production of toxic substances can be reduced, and the prepared product is safer and more reliable. The prepared product is high in effective component content and stable in quality by regulating the time of adding scutellaria baicalensis and decocting platycodon grandiflorum, liquorice, gyp and scutellaria baicalensis twice, and is in accordance with national standard.

Description

technical field [0001] The invention relates to a preparation method of Niuhuangjiedu tablets, in particular to a preparation method of Niuhuangjiedu tablets, and belongs to the technical field of preparation of Chinese patent medicines. Background technique [0002] Niuhuang Jiedu Tablets are developed from Niuhuang Jiedu Pills, a famous medicine with a history of 800 years. It is a famous prescription for clearing away heat and detoxifying. , with definite curative effect, it is still commonly used in clinical practice today, and it is a standing "drug for dispelling gunpowder" in many families. However, in recent years, there have been many reports on the safety problems caused by Niuhuangjiedu Tablets. Since the late 1990s, the Adverse Drug Reaction Monitoring Division of the Drug Evaluation Center of the State Food and Drug Administration has been concerned about the safety of Niuhuangjiedu Tablets. [0003] In "Chinese Pharmacopoeia", Niuhuang Jiedu Tablets are made o...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/708A61K9/20A61P1/02A61P11/04A61K31/045A61K33/06A61K33/36A61K35/413
Inventor 闫保勋赵卫利屈荣华田秀琴陈华瑞段显萍秦秀琴
Owner ZHENGZHOU RUILONG PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap