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Infectious chicken bronchitis vaccine

A bronchitis and chicken infectious technology, applied in the field of chicken infectious bronchitis live vaccine, can solve the problems such as the lack of effective control and commercialization of glandular stomach type IB, and achieve the effect of reducing side effects

Active Publication Date: 2013-04-03
YEBIO BIOENG OF QINGDAO
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  • Summary
  • Abstract
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AI Technical Summary

Problems solved by technology

At present, there are many researches on vaccines used to prevent glandular gastric type infectious bronchitis at home and abroad, but none of them have been commercialized yet.
At the same time, due to the large number of IBV serotypes, there has been no attenuated strain with good cross-protection on the market, and the gastric type IB cannot be effectively controlled

Method used

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  • Infectious chicken bronchitis vaccine
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Embodiment Construction

[0010] The present invention will be further described below in conjunction with specific embodiments. Those skilled in the art should understand that the details and forms of the technical solution of the present invention can be modified or replaced without departing from the spirit and scope of the present invention, but these modifications and replacements fall within the protection scope of the present invention.

[0011] 1. Screening of YB160 strain of attenuated chicken infectious bronchitis used in the present invention

[0012] 10~11-day-old SPF chicken embryos were used to attenuate the virulent infectious bronchitis virus through successive generations. Each generation was inoculated with 4 SPF chicken embryos through the allantoic cavity and passed to 160 generations for attenuation evaluation. Take 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 110, 120, 130, 140, 150, 160 virus strains to inoculate 1 day old SPF chickens. Results There were no dead chickens from the 80th g...

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Abstract

The invention relates to a live vaccine for infectious chicken bronchitis. The live vaccine consists of an antigen and a vaccine adjuvant, wherein the antigen comprises infectious chicken bronchitis viral strain with a collection code CGMCC No. 6752. The prepared vaccine can be used to prevent glandular stomach-type infectious chicken bronchitis. Furthermore, the infectious chicken bronchitis virus constituting the vaccine is a low virulent strain obtained by passage several times, thus reducing the side effect caused by the existing infectious bronchitis virus as the antigen.

Description

Technical field [0001] The invention belongs to the technical field of poultry vaccines, and specifically relates to a live vaccine for infectious bronchitis in chickens. Background technique [0002] Infectious bronchitis (IB) is an acute high-contact respiratory disease caused by infectious bronchitis virus (IBV). It is caused by tracheal rales, coughing, and sneezing; young chickens have runny nose and laying hens. Decrease and egg quality are characteristic; sick chickens often die from respiratory, kidney or digestive tract infections. The disease was first reported in the United States by Schalk et al. in 1931. In 1936, Beach and Hudson determined that the pathogen of the disease was a virus. So far, the disease is widespread worldwide, causing serious harm to the chicken industry. In my country, Kwong Ronglu (1972) first discovered the disease in Guangdong; by the late 1970s, Zheng Furong and others were isolated from their own chicken flocks in Hangzhou, Wu Zhida and ot...

Claims

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Application Information

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IPC IPC(8): A61K39/215A61P31/14
Inventor 宋新宇范根成杜元钊王红李晓林郭伟伟马爽
Owner YEBIO BIOENG OF QINGDAO
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