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Traditional Chinese medicine agent for treating Alzheimer disease

A technology for Alzheimer's disease and traditional Chinese medicine preparations, applied in the field of traditional Chinese medicine preparations for the treatment of Alzheimer's disease, can solve problems such as loss of active ingredients, and achieve the effects of improving dissolution rate, improving bioavailability and good fluidity

Active Publication Date: 2013-04-10
SHANDONG WOHUA PHARMACEUTICALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This formula has achieved a certain effect in the treatment of senile dementia, but its process adopts the method of ethanol precipitation, which leads to the loss of some active ingredients

Method used

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  • Traditional Chinese medicine agent for treating Alzheimer disease
  • Traditional Chinese medicine agent for treating Alzheimer disease
  • Traditional Chinese medicine agent for treating Alzheimer disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Weigh the raw materials according to the following ratio:

[0062] Codonopsis 7.5kg, Guizhi 5kg, Paeoniae Alba 5kg, Licorice 5kg, Poria 7.5kg

[0063] Dried ginger 5kg Polygala 4.5kg Shichangpu 5kg keel 15kg and oyster 15kg

[0064] The production method is as follows:

[0065] Take cassia twigs and dried ginger, add water to distill to produce volatile oil, and re-distill the volatile oil; take other raw materials, add water to soak, combine with the medicinal residue after extracting the volatile oil, decoct and extract twice, each time for 3 hours, combine the extracts, and filter; Concentrate the filtrate under reduced pressure to obtain the extract, mix the volatile oil with the extract, add low-substituted hydroxypropyl cellulose, make granules, add magnesium stearate, compress into tablets, and coat to make 1000 tablets.

Embodiment 2

[0067] Weigh the raw materials according to the following ratio:

[0068] Codonopsis 7.5kg, Guizhi 5kg, Paeoniae Alba 5kg, Licorice 5kg, Poria 7.5kg

[0069] Dried ginger 5kg Polygala 4.5kg Shichangpu 5kg keel 15kg and oyster 15kg

[0070] The production method is as follows:

[0071] Take cassia twigs and dried ginger, add water to distill to produce volatile oil, and re-distill the volatile oil; take other raw materials, add water to soak, combine with the medicinal residue after extracting the volatile oil, decoct and extract twice, each time for 3 hours, combine the extracts, and filter; The filtrate is concentrated under reduced pressure to obtain an extract, the volatile oil is mixed with the extract, and low-substituted hydroxypropyl cellulose is added to make granules.

Embodiment 3

[0073] Weigh the raw materials according to the following ratio:

[0074] Codonopsis 7.5kg, Guizhi 5kg, Paeoniae Alba 5kg, Licorice 5kg, Poria 7.5kg

[0075] Dried ginger 5kg Polygala 4.5kg Shichangpu 5kg keel 15kg and oyster 15kg

[0076] The production method is as follows:

[0077] Take cassia twigs and dried ginger, add water to distill to produce volatile oil, and re-distill the volatile oil; take other raw materials, add water to soak, combine with the medicinal residue after extracting the volatile oil, decoct and extract twice, each time for 3 hours, combine the extracts, and filter; Concentrate the filtrate under reduced pressure to obtain the extract, mix the volatile oil with the extract, add low-substituted hydroxypropyl cellulose, make granules, and pack into capsules.

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Abstract

The invention relates to a traditional Chinese medicine agent for treating Alzheimer disease. The agent is prepared from the following traditional Chinese medicine raw materials in weight part: 7.5 parts of codonopsis pilosula, 5 parts of cassia twig, 5 parts of white peony root, 5 parts of liquorice, 7.5 parts of poria, 5 parts of dried ginger, 4.5 parts of thinleaf milkwort root-bark, 5 parts of acorus gramineus, 15 parts of keel and 15 parts of oyster.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine preparation, in particular to a traditional Chinese medicine preparation for treating Alzheimer's disease. The preparation is prepared from the following Chinese medicine raw materials in the following weight ratio: 7.5 parts of Codonopsis pilosula, 5 parts of Guizhi, and 5 parts of Radix Paeoniae Alba , 5 parts of licorice, 7.5 parts of poria cocos, 5 parts of dried ginger, 4.5 parts of polygala, 5 parts of calamus, 15 parts of keel, and 15 parts of oyster. Background technique: [0002] Alzheimer's disease is a degenerative disease of the central nervous system mainly characterized by progressive cognitive impairment and memory impairment. With the acceleration of the aging process of the population, its incidence has shown an obvious upward trend. And the number four killer after a stroke. The main manifestations of the disease include memory and cognitive dysfunction (including memory loss, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61P25/28A61K35/56A61K35/02A61K35/618
Inventor 曾英姿周万辉于洪亮赵磊张芳芳
Owner SHANDONG WOHUA PHARMACEUTICALS CO LTD
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