Plant empty capsule and preparation method thereof

A plant hollow capsule and glue technology, which is applied in the directions of capsule delivery, food science, pharmaceutical formulation, etc., can solve the problems of gelatin capsule stability greatly affected by temperature, hardening and brittleness, drug leakage, etc., to improve the storage of drugs. , the effect of increasing the breaking strength and reducing the pinhole phenomenon

Inactive Publication Date: 2013-06-05
UNIV OF SHANGHAI FOR SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At the same time, gelatin capsules also have certain limitations, which are mainly reflected in the following aspects: 1. The main component of gelatin capsules is gelatin, which is made from bones and skins of pigs, cattle, and sheep. On the one hand, the use of sex-derived materials increases the unsafety of capsules, especially the outbreak of mad cow disease in Western countries, which aggravates people's concerns about the safety of gelatin capsules; on the other hand, it also makes people with special beliefs and vegetarians unable to eat ; 2. Gelatin capsules have high water content and strong hygroscopicity, and are easy to transfer moisture to the contents of the capsule, causing the drug to fail to absorb moisture or even be inedible; 3. The stability of gelatin capsules is greatly affected by temperature, and it becomes hard at low temperatures Brittle, easy to cause capsule damage, drug leakage, etc.; 4. Gelatin capsules are prone to cross-linking reactions with aldehyde-containing drugs, hindering drug release and prolonging the disintegration time limit

Method used

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  • Plant empty capsule and preparation method thereof
  • Plant empty capsule and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0024] A new nanocomposite plant capsule formula with soybean protein isolate, soybean polysaccharide and nano-bagasse cellulose as main raw materials:

[0025] components

[0026] Weigh a certain amount of soybean protein isolate, soybean polysaccharide and nano-bagasse cellulose with a weight ratio of 3:10:3, add a certain amount of glycerin as a plasticizer, dissolve with an appropriate amount of deionized water, heat and stir to obtain a glue A, weigh a certain amount of sodium alginate and calcium chloride, stir and dissolve to obtain glue B, pour glue B into glue A, heat up to 75°C and expand for 30 minutes, cool down to 40°C after the mixed glue is uniform, Decompression and defoaming for 7 hours, using the traditional film-dipping technology, the new plant hollow capsules were prepared through film-dipping, drying, shelling, cutting, etc.

Embodiment 2

[0028] A new nanocomposite plant capsule formula with soybean protein isolate, soybean polysaccharide and nano-bagasse cellulose as main raw materials:

[0029] components

[0030] Weigh a certain amount of soybean protein isolate, soybean polysaccharide and nano-bagasse cellulose with a weight ratio of 1:5:1, add a certain amount of glycerin, dissolve with an appropriate amount of deionized water, heat and stir to obtain glue A, and Weigh a certain amount of carrageenan and potassium citrate, stir and dissolve to obtain glue B, pour glue B into glue A, heat up to 80°C and puff for 50 minutes, cool down to 50°C after the mixed glue is uniform, and defoam under reduced pressure 8h, using the traditional film-dipping technique, a new type of plant hollow capsule was prepared through film-dipping, drying, shelling, cutting, etc.

Embodiment 3

[0032] A new nanocomposite plant capsule formula with soybean protein isolate, soybean polysaccharide and nano-bagasse cellulose as main raw materials:

[0033] components

[0034] Weigh a certain amount of soybean protein isolate, soybean polysaccharide and nano-bagasse cellulose with a weight ratio of 2:14:5, add a certain amount of polyethylene glycol, dissolve with an appropriate amount of deionized water, heat and stir to obtain a glue A, take a certain amount of agar and potassium chloride and stir to dissolve to obtain glue B, pour glue B into glue A, heat up to 90°C and expand for 45min, cool to 50°C after the mixed glue is uniform, and depressurize Defoaming for 8 hours, using the traditional film-dipping technology, the new plant hollow capsules were prepared through film-dipping, drying, shelling, cutting, etc.

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Abstract

The invention discloses a plant empty capsule and a preparation method thereof. The plant empty capsule takes soy isolate protein, soybean polysaccharide and bagasse cellulose which are of different proportions as main raw materials. The preparation method comprises the following steps of a. after mixing the soy isolate protein, the soybean polysaccharide and nanometer bagasse cellulose, and adding a plasticizer so as to prepare and obtain a glue solution I; b. adding a gelling agent and a coagulant aid into deionized water so as to prepare and obtain a glue solution II; c. mixing the glue solution I and the glue solution II so as to prepare and obtain a glue solution III; d. putting the glue solution III at 40-50 DEG C and decompressing and defoaming; and e. preparing the empty capsule through a membrane dipping manner.

Description

technical field [0001] The invention relates to a plant hollow capsule and a preparation method thereof. Background technique [0002] For a long time, gelatin capsules have been used as the main loading material for some medicines and health-care food raw materials. They have played an active role in protecting the medicines and food raw materials in the capsule, achieving slow release in the body, and covering the smell or taste of the loaded substances. [0003] At the same time, gelatin capsules also have certain limitations, which are mainly reflected in the following aspects: 1. The main component of gelatin capsules is gelatin, which is made from bones and skins of pigs, cattle, and sheep. On the one hand, the use of sex-derived materials increases the unsafety of capsules, especially the outbreak of mad cow disease in Western countries, which aggravates people's concerns about the safety of gelatin capsules; on the other hand, it also makes people with special belief...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/42A61K47/36A23P1/04A23P10/30
Inventor 管骁刘静陈姿含
Owner UNIV OF SHANGHAI FOR SCI & TECH
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