Immune tumor cell screening system based on micro-magnetic field
A tumor cell and magnetic field technology, which is applied in the field of immune tumor cell screening system, can solve the problems of identification interference and damage to tumor cells, and achieve the effects of preventing omission, uniform distribution, and convenient and quick identification process
Active Publication Date: 2013-06-05
NINGBO MEIJING MEDICAL TECH
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[0005] The magnetic body is placed outside the microfluidic channel to separate tumor cells marked by magnetic nanoparticles. The biochip with this structure has the following disadvantages during use: 1. Free nanoparticles and labeled nanoparticle tumor cells often Adsorbed and aggregated in a small area on the slide, this aggregation may interfere with or even damage tumor cells during recognition
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[0016] The present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments.
[0017] An immune tumor cell screening system based on a micro-magnetic field, comprising a microchip 1, a permanent magnet 2 and a microparamagnet array 3, the microchip 1 includes a thin slice 11 and a glass slide 12, and a gap is formed between the thin slice 11 and the glass slide 12 Airtight microfluidic channel 13; Micro paramagnet array 3 is positioned on the slide glass 12 in the microfluidic channel 13, permanent magnet 2 is arranged on the slide glass 12 outside the microfluidic channel 13, the magnetic field of permanent magnet 2 passes through the slide glass The sheet 12 acts on the microparamagnet array 3 . The microparamagnet array 3 is in a rectangular shape, and the rectangular microparamagnet array 3 is formed by uniformly arranging many microparamagnets 31 . There is a groove on the sheet 11 , the groove faces the slide glas...
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Abstract
The invention discloses an immune tumor cell screening system based on a micro-magnetic field. The system comprises a microchip, a permanent magnet, and a micro-paramagnetic body array. The microchip comprises a thin sheet and a glass slide. A sealed microfluidic channel is formed between the thin sheet and the glass slide. The micro-paramagnetic body array is positioned on the glass slide in the microfluidic channel. The permanent magnet is arranged on outside the microfluidic channel and close to the outer surface of the glass slide. The magnetic field of the permanent magnet penetrates the glass slide and acts upon the micro-paramagnetic body array. The system is advantaged in that: the micro-paramagnetic body array can form more uniform magnetic field in the microfluidic channel; nano-particle-marked tumor cells can be more uniformly distributed on the glass slide; tumor cell damage caused by excessive accumulation can be avoided; and subsequent identification process is more convenient and fast.
Description
technical field [0001] The invention relates to an immune tumor cell screening system, in particular to an immune tumor cell screening system based on a micro-magnetic field. Background technique [0002] Blood detection biochip is a next-generation diagnostic tool to detect rare cells in blood related to major diseases, including circulating tumor cells (CTCs), malignant stem cells and diseased cells with specific protein markers circulating in blood samples, etc. . Related studies have confirmed that the number of circulating tumor cells in a patient's blood sample has a strong correlation with the patient's early diagnosis and survival rate. Therefore, the detection and analysis of rare cells in patients' blood samples is the key to improving the early detection rate of tumor diseases and personalized treatment. [0003] The application date of the same applicant's application is November 20, 2012, and the Chinese invention patent application document with the patent nu...
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IPC IPC(8): C12M1/42
Inventor 张晓晶沈挺
Owner NINGBO MEIJING MEDICAL TECH