Calcium acetate-vitamin K pharmaceutical preparation and preparation method thereof

A technology for pharmaceutical preparations and vitamins, applied in the field of medicine, can solve the problems of calcium supplementation products with large side effects, insignificant calcium supplementation effect, poor calcium supplementation effect, etc., and achieve the effects of reducing fracture risk, no toxic side effects, and avoiding discomfort.

Active Publication Date: 2015-03-11
KUNMING BANGYU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many calcium supplement products, some of which are too complex and involve the supplement of various nutrients, and the calcium supplement effect is not obvious; Poor; some calcium supplement products still have problems such as large side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment one: the preparation of granule

[0020] Weigh 700g of calcium acetate, vitamin K 1 2g, Vitamin K 3 2g, Vitamin K 4 2g and 2394g of sucrose, then dissolve vitamin K with 40ml of 95% ethanol 1 , Vitamin K 3 , Vitamin K 4 , then dilute with 350ml of purified water to obtain a wetting agent for later use. After calcium acetate and sucrose are uniformly mixed, the obtained wetting agent is used to make soft materials, granulated, dried at 50° C., sized, and packaged separately to obtain the granules.

Embodiment 2

[0021] Embodiment two: the preparation of granule

[0022] Weigh calcium acetate 600g, vitamin K 1 12g and 2388g of sucrose, then dissolve vitamin K with 30ml of 95% ethanol 1 , then dilute with 250ml of purified water to obtain a wetting agent for later use. Mix calcium acetate and sucrose evenly, use the obtained wetting agent to prepare soft materials, granulate, dry at 40°C, size the granules, and pack separately to obtain the granules.

Embodiment 3

[0023] Embodiment three: the preparation of granule

[0024] Weigh calcium acetate 600g, vitamin K 1 15g and 2694g of sucrose, then dissolve vitamin K with 35ml of 95% ethanol 1 , then dilute with 200ml of purified water to obtain a wetting agent for later use. Mix calcium acetate and sucrose evenly, use the obtained wetting agent to make soft materials, granulate, dry at 50°C, size the granules, and pack separately to obtain the granules.

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PUM

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Abstract

The invention relates to a calcium acetate-vitamin K pharmaceutical preparation and a preparation method thereof, belonging to the technical field of medicine. The calcium acetate-vitamin K pharmaceutical preparation is prepared from 400-1200 parts by weight of calcium acetate, 2-30 parts by weight of vitamin K and a right amount of auxiliary material, wherein the auxiliary material is selected from one or more of sucrose, microcrystalline cellulose, sodium carboxymethyl starch, micropowder silica gel, magnesium stearate, hydroxypropyl methylcellulose, talcum powder, lactose and mannitol. By using the scientific formula, the calcium acetate-vitamin K pharmaceutical preparation can effectively supplement calcium, and is safe and convenient to take.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a calcium acetate vitamin K pharmaceutical preparation and a preparation method thereof. Background technique [0002] Calcium is the most abundant inorganic salt in the human body. The content of calcium in a normal human body accounts for about 0.5%-2.0% of the body weight, of which 99% of calcium exists in bones and teeth, and 1% of calcium is mostly in the form of ions The state exists in soft tissue, extracellular fluid and blood, and maintains a dynamic balance with bones. Calcium has the functions of maintaining the normal response of nerves and muscles, regulating heart beat, keeping the heart contracting and relaxing continuously and alternately, maintaining muscle contraction and transmission of nerve activity and other activities. Due to the problems of eating habits, the residents of our country generally need to take appropriate calcium supplements in order to bett...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/19A61K31/122A61K31/05A61P3/02A61P19/08A61P19/10
Inventor 王冰张永胜刘晓凯郑光明
Owner KUNMING BANGYU PHARMA
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