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Thermal cycler

A heat cycle and radiator technology, applied in laboratory appliances, chemical instruments and methods, heating or cooling equipment, etc., can solve the problems of reduced efficiency and complex efficiency, and achieve the effect of high heat transfer ratio efficiency

Active Publication Date: 2013-07-03
EPISTEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] While convenient, this thermal cycler has a number of disadvantages
Key among these disadvantages is the loss of efficiency when the Peltier element is used for both heating and cooling - e.g. a Peltier device has an effective thermal mass in the form of a heat sink which must itself be heated or cooled to Enables efficient heat transfer to the sample block
Achieving reasonable efficiencies for both heating and cooling is complex, and most thermal cycler designs must compromise between the Peltier element and the desired rate of heat transfer to the sample block

Method used

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Examples

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Embodiment Construction

[0035] First refer to figure 1 , which shows an external view of a thermal cycler according to the present invention. The circulator 10 includes a housing 12 forming a handle 14 . The upper surface of housing 12 is provided with a touch screen interface 16 that allows a user to operate the circulator. The front of the housing is provided with an opening 18 into which a sample holder 20 can be inserted, said sample holder 20 comprising (in this embodiment) three sample tubes 22 made of thin-walled plastic.

[0036] figure 2 The underside of the circulator 10 is shown in . The housing includes an opening 24 within which a cooling fan 26 is mounted, adjacent to a heat sink 28 . The housing is formed with supports 30 which lift the fan 26 off the bench top allowing air to circulate.

[0037] image 3 The internal architecture of the circulator 10 is shown in . Housing 12 is not shown in this figure. A PCB substrate 32 is provided on which the various electronic components...

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Abstract

We describe a thermal cycler comprising a Peltier- type thermoelectric element (36) used for cooling a sample block (34), and a non- Peltier- type heating device (38) for heating the sample block. The cycler also includes a heat sink (28) connected to the Peltier- type element by a heat pipe (40), which permits thermal energy to transfer from the Peltier- type element to the heat sink. This configuration operates more efficiently than conventional thermal cyclers which use Peltier- type elements for heating and cooling, and allows a more rapid cycling time as well as operation in a wider range of ambient temperatures. Certain embodiments utilise the Peltier- type element as a thermal gate to reduce thermal loss during heating when the Peltier- type element is switched off.

Description

technical field [0001] The present invention relates to a thermal cycler device for use in thermal cycling reactions. Aspects of the invention relate to methods of performing thermal cycling reactions. Background technique [0002] The application of thermal cycling methods is an integral part of modern molecular biology. For example, the polymerase chain reaction (PCR) for amplifying nucleic acids uses a series of DNA melting, annealing, and polymerizing steps at different temperatures to greatly "amplify" the amount of DNA in a sample. Other thermal cycling method applications are also known. [0003] A typical thermal cycling device consists of a metal sample module comprising an appropriate number of recesses to accommodate one or more reaction vessels. Sample blocks can be shaped to fit a 96-well plate format or typically 0.5 μl or 0.2 μl microcentrifuge (Eppendorf) tubes. The metal block serves as a thermal mass that transfers its thermal energy to and from the rea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L7/00
CPCB01L2200/14B01L2300/1822B01L2300/1827B01L2300/1844B01L2300/185B01L1/52B01L7/52B01J19/24B01L7/00B01L9/54
Inventor 本·科布
Owner EPISTEM
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