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Cr(III) compound, and preparation method and application thereof

A technology for compounds and products, applied in chemical instruments and methods, active ingredients of heavy metal compounds, compounds containing elements of Group 6/16 of the periodic table, etc., can solve the problems of poor bioavailability, low water solubility, etc. Electricity, good water solubility, good absorption effect

Inactive Publication Date: 2013-07-31
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The parent ring of 4,4'-methylenebis(3-hydroxy-2-naphthoic acid) is a naphthalene ring, which is more hydrophobic, so we speculate that it will have a good lipid-lowering activity, but there is no literature report
The disadvantage of this molecule is its low water solubility and poor bioavailability

Method used

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  • Cr(III) compound, and preparation method and application thereof
  • Cr(III) compound, and preparation method and application thereof
  • Cr(III) compound, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: the preparation of Cr (III) compound

[0018] Put 2.67g (10.0mmol) CrCl3 6H2O and 1.94g (5.0mmol) 4,4'-methylenebis(3-hydroxy-2-naphthoic acid) in a 100mL round bottom flask, dissolve with 40mL methanol, add 1.0 g of arsenic-free zinc granules, slowly drop into 2 mL of anhydrous ethylenediamine under reflux, the color of the solution changes from green to red, continue to react for 30 minutes, a large amount of red powder precipitates after cooling, filter with suction, wash with absolute ethanol and diethyl ether successively Three to five times, dry at room temperature to constant weight, the yield is 80%.

[0019] Elemental analysis and determination, from the molecular formula Cr2C31H46Cl2N8O7, theoretical value: C, 45.54, H, 5.67, N, 13.70, Cr, 12.72; experimental value: C, 45.59, H, 5.79, N, 13.67, Cr, 12.65.

[0020] Conductivity measurement: the complex is soluble in water. Take a complex solution with a concentration of 1.00×10-3mol L-1, and use...

Embodiment 2

[0024] Embodiment 2: the preparation of Cr (III) compound

[0025] Weigh 1.34g (5.0mmol) CrCl3 6H2O and 0.37g (2.5mmol) 4,4'-methylenebis(3-hydroxyl-2-naphthoic acid) into a 50mL round bottom flask, dissolve with 20mL ethanol, Add 0.5 g of arsenic-free zinc particles, drop 1 mL of anhydrous ethylenediamine under reflux, the color of the solution changes from green to red, continue to react for 20 min, a large amount of red powder precipitates, filter with suction, wash with anhydrous organic alcohol and diethyl ether for three times Five times, and dried at room temperature to constant weight, the target product was obtained with a yield of 88%.

Embodiment 3

[0026] Embodiment 3: Weight loss, hypoglycemic activity of Cr (III) compound

[0027] The weight loss activity was verified by feeding mice experiments. Thirty Kunming mice, half male and half male, body weight (10-12 g), were provided by the Experimental Animal Center of Shanxi Academy of Traditional Chinese Medicine. Ordinary feed was provided by Guangzhou Saibainuo Biotechnology Co., Ltd. High-fat feed formula: 66.5% common feed, 20% sucrose, 10% lard, 2.5% cholesterol, 1% sodium cholate. According to body weight, they were randomly divided into 3 groups (half and half males), 10 rats in the normal group, 10 rats in the model group, and 10 rats in the administration group. From the beginning of the experiment, the mice in the normal group were given normal diet, and the other groups were given high-fat diet. Dosing was started after 11 weeks of feeding. The dose was 60g / kg per day, administered orally once a day in the morning, and the experiment lasted for 19 weeks. A...

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Abstract

The invention provides a Cr(III) compound, and a preparation method and an application thereof. The preparation method of the compound comprises the steps of adding Cr(III)Cl3.6H2O and 4,4'-methylene-bis(3-hydroxyl-2-naphthoic acid) to a reactor; dissolving the above materials by an organic alcohol; adding zinc granules, dropping in ethanediamine under a reflux state; reacting for 20-60 min continuously;, wherein 0.73 g of 4,4'-methylene-bis(3-hydroxyl-2-naphthoic acid), 0.1-1 g of the zinc granules, 10-30 mL of the organic alcohol and 0.5-1 g of the ethanediamine are added in every 1 g of Cr(III)Cl3.6H2O; cooling a reaction solution; and filtering to obtain a target product. The compound has good water solubility and a controlled-release function, is beneficial to absorption and can be used for preparing weight-reducing medicines.

Description

technical field [0001] The invention relates to a metal compound, specifically a Cr(III) compound and a preparation method, as well as the application of the compound in the preparation of weight-loss drugs. Background technique [0002] Cr(III) is an essential trace element in mammals. As an insulin sensitizer, it participates in and affects the metabolism of carbohydrates, fats and proteins. Chromium deficiency can reduce the sensitivity of tissues to insulin, leading to type II diabetes and cardiovascular disease. disease. Inorganic chromium ions are easily hydrolyzed and precipitated, and the absorption rate is low. The Cr(III) compound with biomimetic function is easy to synthesize, has good stability, high absorption rate, and is easy to synthesize in large quantities. It has good development prospects and plays an important role in the treatment of type II diabetes. Chromium supplements currently on the market include chromium nicotinate, various amino acid chromium...

Claims

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Application Information

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IPC IPC(8): C07F11/00A61K31/28A61P3/04
Inventor 刘斌王攀峰杨斌盛
Owner SHANXI UNIV
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