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Integrated work-low for accurate input function estimation

A data and scan data technology, applied in the field of arterial input function estimation, can solve the problems of reducing the apparent peak amplitude of the input function, incorrect dynamic model estimation, inaccurate pixels depicting arterial blood, etc., and minimize the invasiveness. Effect

Active Publication Date: 2013-08-21
KONINKLIJKE PHILIPS ELECTRONICS NV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this approach has two disadvantages
First, pixels delineating arterial blood are often inaccurate due to limited scanner resolution, sampling not only blood but also surrounding tissue
Second, coarse temporal sampling will reduce the apparent peak magnitude of the input function, leading to incorrect estimation of the kinetic model

Method used

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  • Integrated work-low for accurate input function estimation
  • Integrated work-low for accurate input function estimation
  • Integrated work-low for accurate input function estimation

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Experimental program
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Embodiment Construction

[0020] The subject innovation overcomes the aforementioned problems in the art by acquiring scan data in list mode and binning the data retrospectively to generate images including arterial regions. When acquiring data in list mode, the raw data is stored in the list, and each entry carries a timestamp indicating the time of acquisition. This makes the raw data available for later analysis or reuse (eg, re-construction), even after the diagnostic image has been reconstructed. Because the data is collected and stored in tabular mode, the size of the time bins can be retrospectively adjusted, and the process repeated for bins of different sizes and time offsets, until the true peak is determined. During the imaging procedure, a blood sample is drawn and the concentration of tracer in the sample is empirically measured. Because these samples are taken relatively late in the imaging process, the concentrations of radiopharmaceuticals in arteries and vessels become substantially e...

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Abstract

When estimating an arterial input function or a patient under study, cross- calibration factors are generated by comparing nuclear scan data of a radioactive material (e.g., F18) and measuring a sample of the radioactive material in a gamma counter. The derived cross-calibration factors are applied to venous samples collected from the patient during a nuclear scan after infusion with a radioactive tracer, to convert gamma values counted by the gamma counter into concentration values. The concentration values are used to optimize an initial estimated input function, thereby generating an arterialized input function.

Description

technical field [0001] The present application is particularly applicable to positron emission tomography (PET) systems, and in particular relates to arterial input function estimation. However, it will be appreciated that the described techniques are also applicable to other medical input function estimation systems, other patient modeling scenarios, or other input function estimation techniques. Background technique [0002] The continued improvement in the hardware capabilities of contemporary medical imaging scanners has generated increased interest in quantitative imaging. Accurate determination of changes in physiological parameters during or at the end of treatment is important for determining the effectiveness of a treatment. For example, PET imaging incorporating pharmacokinetic modeling can provide absolute quantitative measures of metabolism, perfusion, and proliferation, among others. Monitoring changes in many of these parameters enables a more individualized ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B6/03A61B6/00
CPCA61B6/583A61B6/032A61B6/037A61B6/4417A61B6/461A61B6/486A61B6/503A61B6/504A61B6/507A61B6/54G01T1/16
Inventor J-C·格奥尔基M·纳拉亚南
Owner KONINKLIJKE PHILIPS ELECTRONICS NV
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