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Preparation method of gynostemma pentaphyllum polysaccharide-iron complex

A technology of Gynostemma polysaccharide and compound, which is applied in the directions of medical preparations, drug combinations, and pharmaceutical formulations containing active ingredients, can solve problems such as irritation of gastrointestinal mucosa, poor chemical stability, cell membrane damage, etc. The effect of good dissolution performance and simple preparation process

Active Publication Date: 2015-04-08
GUANGXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Iron is one of the essential trace elements for the human body. At present, in clinical practice, ferrous sulfate is used as iron supplement at home and abroad, but this iron supplement method will stimulate the gastrointestinal mucosa, causing nausea, vomiting and diarrhea and other discomfort symptoms. Moreover, the chemical stability is poor, and low-priced iron is prone to generate endogenous free radicals in the body, causing cell membrane damage

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1 Preparation of Gynostemma pentaphyllum polysaccharide iron complex

[0014] Weigh 0.6g of Gynostemma polysaccharide, add 0.2g of sodium alginate, dissolve in 50mL of water, heat in a water bath to 80°C, and keep stirring at a speed of 100r / min, adjust the pH to 8.0 with a mass ratio of 20% sodium hydroxide solution, Slowly add 2mol / L ferric chloride solution dropwise and keep stirring to maintain the pH at 8.0, until reddish-brown insoluble matter appears in the reaction system, stop dripping lye and ferric chloride solution, add dropwise About 0.75mL iron solution, continue stirring and heating at 80°C for 1 hour, stop stirring and heating, remove the precipitated part by centrifugation at 8000rpm, collect the supernatant reddish-brown part of the solution, add 4 times the amount of absolute ethanol according to the volume ratio, and fully stir and mix. Evenly, let it stand overnight at 4°C, remove the supernatant part, wash the precipitated part successively...

Embodiment 2

[0015] Example 2 Preparation of Gynostemma pentaphyllum polysaccharide iron complex

[0016] Weigh 0.6g of Gynostemma polysaccharide, add 0.2g of trisodium citrate, dissolve it in 100mL of water, heat it in a water bath to 80°C, and keep stirring at a speed of 100r / min, adjust the pH to 8.0 with 20% sodium hydroxide solution by mass ratio , slowly add 2mol / L ferric chloride solution dropwise and keep stirring to maintain the pH at 8.0, until reddish-brown insoluble matter appears in the reaction system, stop dripping lye and ferric chloride solution, add dropwise trichloro About 0.75mL of ferric chloride solution, continue stirring and heating at 80°C for 1 hour, stop stirring and heating, centrifuge at 8000rpm to remove the precipitated part, collect the supernatant reddish-brown part of the solution, add 4 times the amount of absolute ethanol according to the volume ratio, and stir thoroughly Mix well, let stand overnight at 4°C, remove the supernatant, wash the precipitate ...

Embodiment 3

[0018] Weigh 0.6g of Gynostemma polysaccharide, add 0.2g of sodium tartrate, dissolve in 100mL of water, heat in a water bath to 80°C, and keep stirring at a speed of 100r / min, adjust the pH to 8.0 with a mass ratio of 20% sodium hydroxide solution, slowly Add dropwise 2mol / L ferric chloride solution and keep stirring to maintain the pH at 8.0, until reddish-brown insoluble matter appears in the reaction system, stop dripping lye and ferric chloride solution, add ferric chloride dropwise The solution is about 0.75mL, continue to stir and heat at 80°C for 1 hour, stop stirring and heating, and centrifuge at 8000rpm to remove the precipitated part, collect the supernatant reddish-brown part of the solution, add 4 times the amount of absolute ethanol according to the volume ratio, stir and mix well , stand overnight at 4°C, remove the supernatant part, wash the precipitate part successively with anhydrous methanol, 95% ethanol, absolute ethanol, and ether, and finally vacuum freez...

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Abstract

The invention discloses a gynostemma pentaphyllum polysaccharide-iron complex. The complex comprises the following components in percentage by weight: 2%-4% of iron and 40%-60% of gynostemma pentaphyllum polysaccharide, and the dissolvability of the complex in per 100mL of water at 25 DEG C is 10g-11g. A preparation method of the gynostemma pentaphyllum polysaccharide-iron complex comprises the steps of: dissolving the gynostemma pentaphyllum polysaccharide and a complexing agent into distilled water, heating in water bath, and dropwise adding a ferric iron compound water solution while stirring, wherein the mass ratio of the gynostemma pentaphyllum polysaccharide to the complexing agent to the ferric iron compound is 3:1:2; and after the reaction, washing with ethanol to obtain the gynostemma pentaphyllum polysaccharide-iron complex. According to the preparation method, the gynostemma pentaphyllum, which is abundant and low in cost, is adopted as a main raw material, the digestion property and stability of the product are better, the water solution is neutral, and the gynostemma pentaphyllum polysaccharide-iron complex can substitute for an existing iron-supplementary agent for supplementing iron for a human body; the preparation technique is simple and easy to popularize; and a new raw material is provided for producing a novel iron-deficiency iron supplementation agent.

Description

technical field [0001] The invention belongs to the technical field of polysaccharide complexes, in particular to a preparation method of Gynostemma pentaphyllum polysaccharide-iron complex. Background technique [0002] Gynostemma (Latin name: Gynostemma pentaphyllum (Thunb.) Makino.), also known as paradise grass, super ginseng, compass bottom, rooting everywhere, aescin and aescin etc. It is rich in physiologically active substances such as gypenoside, sugars, 8 kinds of amino acids and various trace elements necessary for the human body, and has the reputation of "Southern Ginseng". Pharmacological and clinical studies have shown that it has the functions of clearing heat and detoxification, regulating immunity, relieving cough and expectorant, anti-oxidation, anti-cancer and anti-aging, and lowering blood fat. Polysaccharides are one of the main components of living matter. There are many types of polysaccharides in organisms, complex components, and huge structural ru...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/26A61P3/02A61K31/715
Inventor 杨洋严东马万良王峰候杰周莹
Owner GUANGXI UNIV
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