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Holothurian flower extract for treatment of female POF and its preparation method

A technology for premature ovarian failure and sea cucumber flower, which is applied in the directions of medical raw materials derived from echinoderms, medical preparations containing active ingredients, sexual diseases, etc., and achieves the effects of low cost, remarkable effect and easy operation.

Inactive Publication Date: 2015-02-04
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sea cucumber flowers are mostly discarded as waste during sea cucumber processing, and there is no research on the effect of sea cucumber flowers on ovaries at home and abroad. Therefore, it is of great practical significance to separate and extract active ingredients from sea cucumber flowers and apply them to prevent and treat ovarian aging

Method used

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Examples

Experimental program
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Effect test

Embodiment Construction

[0019] 1. Prepare sea cucumber flower extract for treating premature ovarian failure:

[0020] Sea cucumber flowers (fresh and frozen) are provided by Dalian Bangchuidao Seafood Co., Ltd.

[0021] (1) Appropriate amount of sea cucumber flower tissue, homogenate;

[0022] (2) Add 1.5 times the volume of distilled water, and ultrasonically assist extraction at 30°C for 25 minutes;

[0023] (3) Stir and extract in a water bath at 30°C for 2 hours, centrifuge at 4000r / min for 5 minutes, take the supernatant, repeat the above operation for the residue, combine the filtrates, concentrate under reduced pressure to 1 / 3 volume, and freeze-dry to obtain sea cucumber flower extract.

[0024] 2. Preparation of tablets and capsules:

[0025] (1) preparation of sea cucumber flower extract capsule preparation of the present invention

[0026] Weigh 200 mg of the sea cucumber flower extract prepared in the above steps, simultaneously weigh 295 mg of starch and 5 mg of magnesium stearate, m...

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PUM

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Abstract

Relating to the technical field of extraction of effective substances from holothurian flowers, the invention provides a holothurian flower extract for treatment of female POF (premature ovarian failure) and its preparation method. The method includes: taking a proper amount of holothurian flower tissues, conducting homogenization, adding a 1.5 times volume of distilled water, carrying out ultrasonic wave-assisted extraction for 25min at 30DEG C, performing water bath stirring extraction for 2h, conducting centrifugation for 5min at a speed of 4000r / min, taking the supernate, repeating the operations on residue, combining the filtrate, carrying out vacuum concentration to a volume account for 1 / 3 of the original, and performing freeze drying, thus obtaining the holothurian flower extract. The holothurian flower extract can be prepared into tablets and capsules to treat female POF.

Description

technical field [0001] The invention relates to the technical field of extracting effective substances from sea cucumber flowers. Background technique [0002] Premature ovarian failure (POF) refers to the failure of ovarian function in women with normal development before the age of 40 for some reason. The incidence rate of premature ovarian failure before the age of 40 is about 1% to 3%, while the incidence rate within the age of 30 is 0.1%. Premature ovarian failure is characterized by low levels of estrogen produced by the ovaries. So far, the real cause of its onset is still not very clear, so the research on this disease has become a hot spot and difficulty in the field of reproductive development at home and abroad. [0003] Currently, there is no ideal treatment for premature ovarian failure. Western medicine treatment is mainly to supplement estrogen, using estrogen and progesterone, although the symptoms can be improved, but the recovery of ovarian function is n...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/56A61P15/00A61K35/616
Inventor 刘坤高华石振艳刘占涛张婕郭锡春
Owner QINGDAO UNIV
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