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An ultrasonic transmission system and method for improving skin permeability

A transmission system and permeability technology, which is applied in the direction of pharmaceutical devices and other medical devices, can solve the problems of eliminating the negative effect of the medium, limiting the amount of input, limiting the positive effect of the medium, etc., to prolong the action time and promote the transfer , to avoid the effect of negative effects on the whole body

Active Publication Date: 2016-04-20
北京诺亚同舟医疗技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sometimes in order to ensure safety, the amount of input is often limited, which also greatly limits the positive effect of the medium, and even many media with strong positive effects are eliminated due to insurmountable negative effects

Method used

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  • An ultrasonic transmission system and method for improving skin permeability
  • An ultrasonic transmission system and method for improving skin permeability
  • An ultrasonic transmission system and method for improving skin permeability

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0047] In the process of applying the medium of chemotherapy to tuberculous pleurisy, the ultrasonic transmission system for improving skin permeability of the present invention is used as an auxiliary device for medium transmission.

[0048] Experimental population and grouping: 71 cases, 28 males and 43 females, aged 18-52 (average 29) years old, disease course 1 week-1 month, average 21 days, chronic diseases such as diabetes, hypertension, liver and kidney insufficiency were excluded And pleural thickening, local wrapping patients. The 71 patients were randomly divided into a control group of 34 cases and an experimental group of 37 cases. There was no significant difference between the two groups in terms of gender, age, and course of disease, and they were comparable.

[0049] Experimental method: the experimental group uses a special medium gel formulation to form a coupling conduction unit, and at the same time uses the ultrasonic transmission system of the present inv...

Embodiment 2

[0065] 1. Implementation plan

[0066] Utilize the ultrasonic transmission system for improving skin permeability of the present invention to promote local penetration of plant ingredients cassia twig ingredients. In this embodiment, rabbits are selected as the research object, and the ultrasonic transmission system for improving skin permeability of the present invention is used to observe the effect of the penetration-promoting effect of cinnamon aldehyde, the main component of cassia twig, to verify the ultrasonic transmission system for improving skin permeability of the present invention. Systemic penetration facilitation.

[0067] 10 rabbits were divided into an experimental group and a control group, and the ultrasonic transmission system for improving skin permeability of the present invention was used to penetrate 5% cassia twig extract into the knee joints of the experimental group rabbits, and the control group was given the cassia twig liquid naturally. penetratio...

Embodiment 3

[0082] implementation plan

[0083] The application of the ultrasonic transmission system and method for improving skin permeability of the present invention assists in the experimental research of the tumor suppression effect of mediators that enhance the chemotherapy effect. Transplant human melanoma cells MV3 in nude mice, use the ultrasonic transmission system (frequency 30KHz, ultrasonic intensity 0.9W / cm2) of the present invention to improve skin permeability and intraperitoneal injection of fluorouracil (50mg / kg, ip, q4d) The method of local radiation of tumors in nude mice was compared with the group of injecting fluorouracil alone and applying low-frequency ultrasound alone. The inhibitory effect of the above conditions on human melanoma cell MV3 transplanted tumor was observed. Use the system of the present invention once a day, 30 minutes each time, 720 times as a course of treatment.

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Abstract

The invention provides an ultrasound transmission system for improving skin permeability. The ultrasound transmission system for improving the skin permeability comprises an ultrasound excitation current generation module, a pulse current generation module, a feedback regulation module, a control module, an application module and a display setup module. The invention further provides an ultrasound transmission method for improving the skin permeability. The application module is closely connected and fixed with the human skin through media. Pulse currents after being processed by the pulse current generation module and the control module are transmitted to the human body through the application module. Excitation currents after being processed by the ultrasound excitation current generation module and the control module act on the application module and then generate ultrasonic waves transmitted to the action portion of the human body. When the steps are carried out, the pulse current generation module generates the drive pulse currents output continuously or discontinuously at the same time, the drive pulse currents and the ultrasonic waves generated in the former step are output through the application module synchronously or sequentially, and transmission of medium molecules in the tissue is promoted.

Description

technical field [0001] The invention relates to an ultrasonic transmission system and method for improving skin permeability, and belongs to the field of instruments for transmitting media into human body. Background technique [0002] Various ways and methods make foreign substances enter the body and then transport and metabolize to the target tissue. The route of administration refers to the way of drug media and human contact in pharmacology and toxicology. The drug delivery route strongly affects the effects of various mediators in the body through the body's own transportation and metabolic processes. [0003] After the medium enters the human body through different channels, it forms a certain concentration in the blood, and then distributes to various tissues of the whole body along with the circulation, forming a certain tissue concentration. Part of the medium entering the target tissue exerts a positive effect, while the medium distributed in the normal tissue of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M37/00
Inventor 郑淑丽翁春晓
Owner 北京诺亚同舟医疗技术有限公司
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