Isoprene synthase variants for improved production of isoprene

A technology of isoprene synthase and dimer, applied in the field of mutant plant isoprene synthase, can solve the problem of insufficient isoprene content for commercial use
CN103443271AInactive Publication Date: 2013-12-11DANISCO US INC +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
DANISCO US INC
Publication Date
2013-12-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides methods and compositions comprising at least one isoprene synthase enzyme with improved specific productivity. In particular, the present invention provides variant plant isoprene synthases for increased isoprene production in host cells.
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Description

[0001] Cross references to related patent applications

[0002] This patent application claims priority to US Provisional Patent Application No. 61 / 407,415, filed October 27, 2010, the entire contents of which are hereby incorporated by reference. technical field

[0003] The present invention provides methods and compositions comprising isoprene synthase variants. In particular, the present invention provides variant plant isoprene synthases for use in increasing isoprene production in a host cell. Background technique

[0004] Isoprenoids are isoprene polymers used in pharmaceuticals, nutraceuticals, flavors, fragrances and rubber products. However, the supply of natural isoprenoids is limited due to ecological concerns. Therefore, to provide isoprenoid compositions with fewer impurities and greater uniformity, isoprenoids, such as rubber, are typically produced synthetically.

[0005] Isoprene (2-methyl-1,3-butadiene) is a volatile hydrocarbon that is insoluble in wate...

Claims

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