Cleansing solution for curing gynecological disease and preparation method thereof

A lotion and women's technology, applied in the field of lotion for the treatment of gynecological diseases, can solve the problems of short retention time of active ingredients, insufficient antibacterial effect, insufficient killing of pathogenic bacteria, etc., and achieve a good antibacterial synergistic effect

Inactive Publication Date: 2013-12-18
北京中润启源生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] As a topical antibacterial agent and wound care agent for vaginal use, although chitosan has a good effect on wound repair (for example, in wound repair and care), it is obviously insufficient in terms of antibacterial properties, especially in killing pathogenic bacteria , especially in the form of lotion, when washing the vagina, the active ingredients in the lotion have a short retention time in the vagina and a low effective concentration. Chitosan alone is a component that is suitable for the treatment of severe and intractable gynecological diseases. , there is insufficient antibacterial effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Embodiment 1, chitosan chlorhexidine women's lotion and preparation method thereof

[0070] Recipe: Chitosan 0.25g (viscosity average molecular weight 60,000, deacetylation degree ≥ 90%)

[0071] Chlorhexidine acetate 0.2g

[0072] Glycerin 8g

[0073] 37% mixture of hydrochloric acid and glacial acetic acid (V:V=5:1) appropriate amount

[0074] Purified water was added to 100g.

[0075] Preparation method: it includes mixing chitosan with purified water to form a suspension in an environment with a cleanliness of 100,000, adding a mixture of hydrochloric acid and glacial acetic acid to make the reactants form a lotion, and make the pH of the lotion at 4-5, get chitosan solution, take chlorhexidine acetate and dissolve it in glycerin, add it to chitosan lotion, stir evenly, degas, fill in plastic bottle or vaginal douche bottle and seal, further use 10- The cobalt-60 radiation sterilization treatment of 11KGy dosage promptly obtains the chito...

Embodiment 2

[0076] Embodiment 2, the following chitosan chlorhexidine women's lotion of formula

[0077] Formula: Chitosan 0.3%~0.7%,

[0078] Chlorhexidine 0.1%~0.5%,

[0079] Glycerin 5%~10%,

[0080] Proper amount of acidulant,

[0081] Add purified water to 100g;

[0082] Wherein, chlorhexidine includes chlorhexidine acetate, chlorhexidine gluconate, chlorhexidine hydrochloride or chlorhexidine citrate, and the acidulant is a mixture of lactic acid, acetic acid or hydrochloric acid-acetic acid, and the lotion is passed through The viscosity change rate after cobalt-60 radiation treatment is less than + 10%, the pH value of the lotion is 3.8-5.8. The preparation method of above-mentioned chitosan chlorhexidine women's lotion is as follows:

[0083] It includes mixing chitosan with purified water to form a suspension in an environment with a cleanliness of 100,000, adding an acidulant to adjust the pH to 3.8-5.8 to obtain a chitosan solution, and dissolving c...

Embodiment 3

[0084] Embodiment 3, chitosan chlorhexidine women's lotion and preparation method thereof

[0085] Recipe: Chitosan 0.4g (viscosity average molecular weight 50,000, deacetylation degree ≥ 95%)

[0086] Chlorhexidine acetate 0.3g

[0087] Menthol 0.01g

[0088] Glycerin 8g

[0089] 37% mixture of hydrochloric acid and glacial acetic acid (V:V=5:1) appropriate amount

[0090] Purified water was added to 100g.

[0091] Preparation method: it includes mixing chitosan with purified water to form a suspension in an environment with a cleanliness of 100,000, adding a mixture of hydrochloric acid and glacial acetic acid to make the reactants form a lotion, and make the pH of the lotion at 4-5, get chitosan solution, take chlorhexidine acetate and menthol and dissolve in glycerin, add chitosan lotion, stir evenly, degas, fill in high-density polyethylene vaginal douche bottle and seal, Further use the cobalt-60 radiation sterilization treatment of 10~...

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Abstract

The invention relates to sterile cleansing solution for women. The cleansing solution is composed of chitosan with a specific molecular weight and deacetylation degree, chlorhexidine, glycerol, acidifier and purified water. The cleansing solution is applied in the environment with hundred-thousand-level cleanliness, the chitosan and the purified water are mixed to form suspension liquid, acidifier is added in the suspension liquid to adjust the pH value to be within the range from 3.8 to 5.8, and chitosan gel is obtained. The chlorhexidine is additionally taken and is dissolved in the glycerol and is added in the chitosan gel, the chitosan gel is evenly stirred, degasification is conducted, filling sealing is conducted and sterilization is conducted, wherein the acidifier is lactic acid or acetic acid or the mixture of hydrochloric acid and acetic acid, and Co-60 irradiation processing or high-temperature damp and hot sterilization is conducted during the sterilization process. The invention further relates to the manufacturing method of the cleansing solution for curing the gynecological disease and the application of the cleansing solution in preparation of medicines for curing women monilial vaginitis, bacterial vaginitis, trichomonas vaginitis or cervicitis, and the sterile cleansing solution for women can be used for daily hygiene care of the vagina of a woman.

Description

technical field [0001] The present invention relates to the field of pharmaceutical products. Specifically, the present invention relates to a lotion for treating gynecological diseases, which is used for the treatment of women's candida vaginitis, bacterial vaginitis, mixed vaginitis, and cervicitis. The curative effect, safety, natural, good biocompatibility and other advantages, the invention also relates to its preparation method and medical application. Background technique [0002] Ideal gynecological topical pharmaceutical products should have good antibacterial and anti-inflammatory properties, safety, biocompatibility, and ease of use. They should also be stable, easy to store, and easy to use. [0003] Chitosan (Chitosan), chemically named poly(1,4)-2-amino-2-deoxy-β-D-glucose, is a natural biopolymer obtained after partial or complete deacetylation of chitin. It is the only macromolecular alkaline polysaccharide existing in nature, also known as soluble chitin, c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/722A61P31/04A61P15/02A61P15/00A61P33/02A61K31/155
Inventor 张耿元白东跃庄灵习王保红
Owner 北京中润启源生物科技有限公司
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