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New use of erythropoietin in high altitude sickness

A technology for erythropoietin and altitude sickness, which is applied in the field of new use of erythropoietin in altitude sickness, and can solve problems such as no erythropoietin.

Inactive Publication Date: 2013-12-18
史克勇
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But so far there is no report on the use of erythropoietin for altitude sickness

Method used

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  • New use of erythropoietin in high altitude sickness

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Embodiment 1: Preclinical effectiveness evaluation

[0011] 1. Experimental animals

[0012] ICR mice, half male and half male, 18~22g.

[0013] 2. Main reagents

[0014] Recombinant human erythropoietin injection: Shenyang Sansheng Pharmaceutical Co., Ltd., batch number 001700403.

[0015] Sample diluent: Take 0.1g of bovine serum albumin and dilute to 100mL with normal saline.

[0016] 3. Experimental method

[0017] Mice were intravenously administered recombinant human erythropoietin injection 10IU / mouse, 20IU / mouse, 40IU / rat, 3 consecutive times, 1 time / day. One hour after the last administration, the animals in each group were intraperitoneally injected with sodium nitrite at a dose of 250 mg / kg body weight, and the survival time of the animals was observed.

[0018] 4. Experimental results

[0019] It can be seen from Table 1 that compared with the negative control group, the three dose groups of the test substance can significantly prolong the survival tim...

Embodiment 2

[0025] Embodiment 2: human body effectiveness evaluation

[0026] Recombinant human erythropoietin injection (Shenyang Sansheng Pharmaceutical Co., Ltd.) was used to treat 5 cases of acute altitude sickness (150IU / kg body weight) caused by stationing in areas above 3600m above sea level. Results: Recombinant human erythropoietin was effective in treating acute altitude sickness without other side effects.

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Abstract

The invention relates to a new use of erythropoietin, namely the use of erythropoietin in treatment of high altitude sickness.

Description

technical field [0001] The invention relates to the new application of existing medicines, in particular to the application of erythropoietin for treating altitude sickness. Background technique [0002] China is the first country in the world to recognize acute mountain sickness. As far back as 328 BC, Du Qin, the great general of Emperor Cheng of the Han Dynasty, wrote to Wang Feng, the then prime minister, suggesting not to send special envoys to Kashmir and Afghanistan. Because going to these places has to pass through the Big Headache Mountain and Little Headache Mountain in the Pishan Mountains (now the Karakoram Pass), which will cause severe headaches, dizziness and vomiting. These symptoms are consistent with the manifestations of modern acute mountain sickness, which shows that altitude sickness was known at that time. Acute mountain sickness is a variety of pathological reactions after the human body is rapidly exposed to hypoxic environments, and it is a common...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/18A61P39/00A61P39/02
Inventor 史克勇
Owner 史克勇
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