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Preparation method for spinosad/avilamycin composite polymeric micelle insecticide

A composite polymer and avermycin technology, applied in the direction of insecticides, biocides, botany equipment and methods, etc., can solve the problems of short killing duration and difficult absorption of pests, and achieve no pesticide residues, Strong medicinal effect, no pollution to the environment

Active Publication Date: 2013-12-25
陕西格丽达生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some antibiotic drugs are poorly soluble drugs, which are difficult to absorb when entering the pest body, and the killing duration is short, which requires the application of modern pharmacy principles to design new dosage forms

Method used

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  • Preparation method for spinosad/avilamycin composite polymeric micelle insecticide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Composition: 10 parts spinosad, 10 parts avermycin, 150 parts polyethylene glycol, 150 parts polypropylene

[0021] Polyethylene glycol has a molecular weight of 6000 and polypropylene has a molecular weight of 5000.

[0022] The preparation method of above-mentioned spinosyn and avermycin composite polymer micelle insecticide comprises the steps:

[0023] (1) Put polyethylene glycol and polypropylene into the reaction vessel under the condition of 140°C in a vacuum state, add a catalyst, and react for 40 hours to obtain an amphiphilic block copolymer;

[0024] (2) dissolving the above-mentioned amphiphilic block copolymer in water to obtain an aqueous solution;

[0025] (3) Add spinosad and avermycin into acetone, stir to dissolve completely, and obtain an oily solution;

[0026] (4) At 50°C, slowly add the above oil solution into the aqueous solution while vigorously stirring for 0.8 hours, and continue stirring to completely volatilize the acetone;

[0027] (5) Fi...

Embodiment 2

[0030] Composition: 10 parts of spinosad, 5 parts of avermycin, 100 parts of polyoxyethylene, 100 parts of polystyrene

[0031] Polyoxyethylene has a molecular weight of 3000 and polystyrene has a molecular weight of 2000.

[0032] The preparation method of above-mentioned spinosyn and avermycin composite polymer micelle insecticide comprises the steps:

[0033] (1) Put polyoxyethylene and polystyrene into the reaction vessel under the condition of 150°C in a vacuum state, add a catalyst, and react for 50 hours to obtain an amphiphilic block copolymer;

[0034] (2) dissolving the above-mentioned amphiphilic block copolymer in water to obtain an aqueous solution;

[0035] (3) Add spinosad and avermycin into acetone, stir to dissolve completely, and obtain an oily solution;

[0036] (4) At 60°C, slowly add the above oil solution into the aqueous solution, while vigorously stirring for 1 hour, and continue stirring to completely volatilize the acetone;

[0037] (5) Filter and ...

Embodiment 3

[0040] Composition: 10 parts of spinosad, 15 parts of avermycin, 200 parts of povidone, 200 parts of polyamino acid

[0041] The molecular weight of povidone is 10000, and the molecular weight of polyamino acid is 8000.

[0042] The preparation method of above-mentioned spinosyn and avermycin composite polymer micelle insecticide comprises the steps:

[0043] (1) Put povidone and polyamino acid into the reaction vessel under the condition of 120°C in a vacuum state, add the catalyst, and react for 30 hours to obtain the amphiphilic block copolymer;

[0044] (2) dissolving the above-mentioned amphiphilic block copolymer in water to obtain an aqueous solution;

[0045] (3) Add spinosad and avermycin into acetone, stir to dissolve completely, and obtain an oily solution;

[0046] (4) At 40°C, slowly add the above oil solution into the aqueous solution while vigorously stirring for 0.5 hours, and continue stirring to completely volatilize the acetone;

[0047] (5) Filter and fr...

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Abstract

The invention discloses a preparation method for a spinosad / avilamycin composite polymeric micelle insecticide. The insecticide is mainly composed of the following components: in parts by weight, 10 parts of spinosad, 8-12 parts of avilamycin, 140-160 parts of a hydrophilic segment material and 140-160 parts of a hydrophobic segment material. Compared with the prior art, the obtained spinosad / avilamycin composite polymeric micelle insecticide has the characteristics of strong drug effect and long persistent period. The spinosad / avilamycin composite polymeric micelle insecticide is capable of effectively killing insects comprising lepidoptera, diptera and thysanoptera insects, and also has poisoning effect on certain specific kinds of insects in coleoptera, orthoptera, hymenoptera, isopteran, siphonaptera, dermaptera and corrodentia.

Description

technical field [0001] The invention relates to a preparation method of a biological pesticide, in particular to a preparation method of a spinosad and avermectin composite polymer micelle insecticide, which is applied in the field of agriculture. Background technique [0002] Biopesticides refer to living organisms and their metabolites and genetically modified products used to prevent and control harmful organisms such as diseases, insects, and grasses, and can be made into commercial biological source preparations, including bacteria, viruses, fungi, nematodes, plants, natural enemies of insects, Agricultural antibiotics, plant growth regulators and transgenic plants resistant to diseases, insect pests and weeds, etc. Biological pesticides have been used in agricultural production for half a century, but the development has been relatively slow due to various reasons. In recent years, people pay more and more attention to the sustainable development of agricultural produ...

Claims

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Application Information

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IPC IPC(8): A01N43/90A01N25/28A01P7/04A01P11/00A01N43/22
Inventor 卞佳林
Owner 陕西格丽达生物科技有限公司
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