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Preparation method for daytime-taken softgel for treating cold

A technology for soft capsules and daily use, which is applied in the fields of capsule delivery, medical preparations containing active ingredients, and pharmaceutical formulas. It can solve the problems of complex preparation process and poor product stability, and achieve simple process, beautiful appearance and convenient production. Effect

Active Publication Date: 2013-12-25
安士制药(中山)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing preparation process is complicated, and the stability of the prepared product is relatively poor

Method used

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  • Preparation method for daytime-taken softgel for treating cold
  • Preparation method for daytime-taken softgel for treating cold
  • Preparation method for daytime-taken softgel for treating cold

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The soft capsule of the present invention comprises a soft capsule rubber and a content wrapped in the soft capsule rubber, and the content comprises the following components by weight percentage:

[0029]

[0030] Wherein said soft capsule rubber consists of the following components by weight percentage:

[0031] Gelatin 50%

[0032] Plasticizer 45%

[0033] Purified water 5%.

[0034] Wherein said polyethylene glycol is polyethylene glycol 400; said polyhydric alcohol is one or both of propylene glycol and glycerin. The povidone is povidone K12; the plasticizer is glycerin.

[0035] Soft capsule of the present invention can be prepared by following process:

[0036] 1. Preparation of gelatin solution:

[0037] Dissolve the plasticizer in water, add it to the plastic tank and heat it to 40°C, add gelatin, stir to dissolve above 60°C, and set aside;

[0038] 2. Preparation of contents:

[0039] Mix polyethylene glycol, polyol. Add povidone into the above mixt...

Embodiment 2

[0043] The soft capsule of the present invention comprises a soft capsule rubber and a content wrapped in the soft capsule rubber, and the content comprises the following components by weight percentage:

[0044]

[0045] Wherein said soft capsule rubber consists of the following components by weight percentage:

[0046] Gelatin 90%

[0047] Plasticizer 5%

[0048] Purified water 5%.

[0049] Wherein said polyethylene glycol is the mixture of polyethylene glycol 200 and polyethylene glycol 400. Described polyhydric alcohol is the mixture of propylene glycol, glycerin. The povidone is a mixture of povidone K12, povidone K17 and povidone K25. The plasticizer is a mixture of glycerin, sorbitol, part of sorbitan, maltitol, mannitol, propylene glycol, polyethylene glycol 200, and polyethylene glycol 400.

[0050] Soft capsule of the present invention can be prepared by following process:

[0051] 1. Preparation of gelatin solution:

[0052] Dissolve the plasticizer in wat...

Embodiment 3

[0058] The soft capsule of the present invention comprises a soft capsule rubber and a content wrapped in the soft capsule rubber, and the content comprises the following components by weight percentage:

[0059]

[0060] Wherein said soft capsule rubber consists of the following components by weight percentage:

[0061]

[0062] Wherein said polyethylene glycol is the mixture of polyethylene glycol 200, polyethylene glycol 400 and polyethylene glycol 600. Described polyhydric alcohol is propylene glycol. The povidone is a mixture of povidone K12, povidone K17, povidone K25, povidone K29 / 32 and povidone K30.

[0063] Described plasticizer is maltitol. Described colorant is FD&C Yellow No.6.

[0064] Soft capsule of the present invention can be prepared by following process:

[0065] 1. Preparation of gelatin solution:

[0066] Dissolve the plasticizer in water, add it to the glue tank and heat it to 70°C, add gelatin, stir and dissolve above 80°C. Add the coloring ag...

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Abstract

The invention discloses a preparation method for a daytime-taken softgel for treating a cold. The preparation method comprises the following steps: A, preparation of a gelatin liquor: dissolving plasticizer in water, adding into a gelatin melting tank, adding gelatin, stirring to dissolve, adding coloring agent into water, stirring uniformly to obtain a pigment solution, adding the pigment solution into an obtained gelatin solution, stirring and vacuumizing to exhaust air bubbles, so as to obtain the gelatin liquor; B, preparation of contents: adding mixed polyethylene glycol and polyhydric alcohol into polyvidone, stirring to dissolve, adding acetaminophen, stirring to obtain a suspension, adding into a proportioning tank, vacuumizing, filling with inert gas, heating to dissolve, cooling, adding dextromethorphan hydrobromide and phenylephrine hydrochloride, vacuumizing, and keeping the temperature to dissolve, so as to obtain a content solution; C preparation of the softgel: adding the gelatin liquor and the content solution into a pelleting machine respectively, pelleting, drying, pellet plastering and packaging. The invention aims to provide the preparation method for the daytime-taken softgel which is used for treating the cold, and is simple in process, convenient to manufacture and good in product stability.

Description

technical field [0001] The invention relates to a preparation method of daily-use soft capsules for treating colds. Background technique [0002] As a common respiratory disease, colds are mainly characterized by headache, fever, cough, nasal congestion, runny nose, and allergies. Medications commonly used to treat these symptoms include acetaminophen, an antipyretic and pain reliever, dextromethorphan hydrobromide, a cough suppressant, and phenylephrine hydrochloride, a decongestant. [0003] Due to the different properties and stability of these drugs, it is a challenge to produce compound preparation products containing the above drugs and make the drugs in them stable and effective. The existing preparation process is complex, and the prepared product has poor stability. Therefore, the existing technology for making the daily-use soft capsules for treating colds containing these medicines needs to be further improved. Contents of the invention [0004] The purpose o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/485A61P29/00A61P11/14A61P11/02A61P37/08A61K31/167A61K31/137
Inventor 符联昌贾卫东
Owner 安士制药(中山)有限公司
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