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Application of incarviatone A in the preparation of anti-tuberculosis drugs

A technology for anti-tuberculosis and drugs, applied in the application field of preparing anti-tuberculosis drugs, to achieve the effects of strong tuberculosis inhibitory activity, expanded types, and broad application prospects

Inactive Publication Date: 2015-12-23
重庆市黔江区阿蓬科技企业孵化器有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the irregular treatment and management of tuberculosis patients, irregular chemotherapy and abuse of anti-tuberculosis drugs, the drug resistance of tuberculosis is becoming more and more serious, and the change of drug resistance tends to be multi-drug resistance at the same time. great difficulty at work

Method used

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  • Application of incarviatone A in the preparation of anti-tuberculosis drugs
  • Application of incarviatone A in the preparation of anti-tuberculosis drugs
  • Application of incarviatone A in the preparation of anti-tuberculosis drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: the preparation of compound IncarviatoneA tablet involved in the present invention:

[0017] Get 20 grams of compound Incarviatone A, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.

Embodiment 2

[0018] Embodiment 2: the preparation of compound IncarviatoneA capsules involved in the present invention:

[0019] Get 20 grams of compound Incarviatone A, add conventional auxiliary materials for preparing capsules such as 180 grams of starch, mix well, and pack into capsules to make 1000 tablets.

[0020] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0021] Experimental Example 1 Solid Medium Dilution Method Determination of IncarviatoneA Anti-Bacillus Calmette-Guerin (BCG) Absolute Concentration

[0022] Scrape the BCG culture from the inclined surface, add it to 3ml Middlebrook7H9 broth medium, add a small amount of glass beads, tighten the test tube cap, vibrate and grind vigorously on the vortex oscillator, and compare it with the standard McFarland turbidimetric tube (MacFarland No.1). Turbidity, that is to make 1mg / ml bacillus Calmette-Guerin (BCG) bacterial suspension.

[0023] IncarviatoneA is made into a high-concentration stock solution with DMSO, and the stock solution is diluted to the required concentration with 5% Tween-80 sterile ultrapure water, and the diluted IncarviatoneA is added to 4mlMiddlebrook7H11 agar medium according to the required dose (the culture The base has been sterilized by high pressure steam at 121°C for 15 minutes, cooled to 50-55°C), mixed evenly to make Incarviatone A, the concentrati...

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PUM

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Abstract

The invention discloses application of Incarviatone A in preparation of anti-tubercle bacillus medicaments. According to the current situation that tuberculosis morbidity and mortality rise due to high tuberculosis morbidity and presence of multiple-resistant strains of tubercle bacilli at present, the Incarviatone A has obvious tubercle bacillus inhibiting activity and good application prospect as discovered. The application of the Incarviatone A in preparation of the anti-tubercle bacillus medicaments is made public for the first time, the skeleton type is completely novel and the Incarviatone A has an unexpectedly strong tubercle bacillus inhibiting activity, so the probability that other compounds give any revelation does not exist, outstanding substantive features are provided, meanwhile, prominent improvement is evidently made in prevention and treatment of tubercle bacillus infection.

Description

technical field [0001] The invention relates to the application field of pharmaceutical compounds, in particular to the application of Incarviatone A in the preparation of anti-tuberculosis drugs. Background technique [0002] In recent years, the incidence of tuberculosis in the world has shown an increasing trend. According to the World Health Organization (WHO) estimates, the population infected by Mycobacterium tuberculosis (MTB) accounts for one-third of the world's population, and 5-10% of them are infected. become tuberculosis patients. There are 1.3 million cases of active tuberculosis patients in my country every year, including about 600,000 cases of infectious tuberculosis, and about 600,000 cases of infectious tuberculosis. It is one of the countries with a high burden of tuberculosis in the world. [0003] Since the advent of anti-tuberculosis drugs one after another, the treatment of tuberculosis has played an epoch-making change. However, due to the irregula...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61P31/06
Inventor 张红丽
Owner 重庆市黔江区阿蓬科技企业孵化器有限公司
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