Method for preparing starch-base soft capsules based on co-blending extrusion method

A technology of starch and capsules, which is applied in the fields of capsule delivery, pharmaceutical formula, food forming, etc. It can solve problems such as uneven mixing and lax capsule inclusion, and achieve the effect of reducing costs

Active Publication Date: 2014-01-08
ZHONGSHAN KAIBOSI STARCH MATERIAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The invention discloses a preparation method of starch soft capsules, aiming to solve the problems of uneven mixing and lax encapsulation of capsules in the existing mixing technology

Method used

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  • Method for preparing starch-base soft capsules based on co-blending extrusion method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The raw materials used and the weight ratio are as follows:

[0040] Gel agent: carrageenan, 2%;

[0041] Starch: corn starch, 75%;

[0042] Moisture retention agent: pharmaceutical grade glycerin, 1%;

[0043] Anticaking agent: pharmaceutical grade stearic acid, 0.2%;

[0044] Emulsifier: pharmaceutical grade sodium lauryl sulfate, 0.02%;

[0045] Paste agent: deionized water, 21.78%.

[0046] The parameters of the twin-screw extruder are as follows:

[0047] The rotating speed of screw rod is 350 rev / mins, and wherein the temperature that each slide block is set is:

[0048] Slider 1: 25°C

[0049] Slider 2-3: 110°C

[0050] Sliders 4-6: 145°C

[0051] Sliders 7-9: 165°C

[0052] Slider 10-12: 160°C

[0053] Nozzle: 160°C

[0054] The parameters of the single screw extruder are as follows:

[0055] Extrude under the condition that the rotation speed of the screw is 300 rpm, and the temperature set by each slider is 120°C.

[0056] The preparation steps of...

Embodiment 2

[0058] The raw materials used and the weight ratio are as follows:

[0059] Gel agent: xanthan gum, 2%;

[0060] Starch: corn starch, 75%;

[0061] Moisture retention agent: pharmaceutical grade glycerin, 3%;

[0062] Anticaking agent: pharmaceutical grade stearic acid, 0.2%;

[0063] Emulsifier: pharmaceutical grade sodium lauryl sulfate, 0.02%;

[0064] Pasting agent: deionized water, 19.78%;

[0065] All the other are with embodiment 1.

Embodiment 3

[0067] The raw materials used and the weight ratio are as follows:

[0068] Gel agent: guar gum, 2%;

[0069] Starch: tapioca starch, 75%;

[0070] Moisture retention agent: pharmaceutical grade glycerin, 1%;

[0071] Anticaking agent: pharmaceutical grade stearic acid, 0.5%;

[0072] Emulsifier: pharmaceutical grade sodium lauryl sulfate, 0.02%;

[0073] Pasting agent: deionized water, 21.48%;

[0074] All the other are with embodiment 1.

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Abstract

The invention discloses a method for preparing starch-base soft capsules. According to the method for preparing the starch-base soft capsules, a composite starch film is made through blending and extrusion of a composite starch-base phase and gels, and then the composite starch film is made into the starch-base soft capsules through a rotating film stamping method.

Description

technical field [0001] The invention relates to a method for preparing soft capsules, in particular to a method for preparing non-gelatin soft capsules. Background technique [0002] Capsules are generally used to package drugs that are not suitable for direct contact with the esophagus and need to be disintegrated in the stomach or intestinal tract. At present, most capsules of medicinal or health food are made of gelatin, which comes from animal skin or bone, and is obtained by boiling with acid or alkali. In the production process, there will inevitably be animal protein residues, which will interact with the drugs contained in them, resulting in adverse consequences such as drug deterioration. [0003] In addition, gelatin from animal sources is unacceptable to vegetarians and those who hold Islamic, Jewish and other religious beliefs. Similarly, for people with allergies, gelatin products should also be avoided. [0004] Starch is of plant origin, its sources are ext...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K9/48A61J3/07A23P1/04A23L27/00A23L29/212A23P10/30
CPCA61K9/4816A61K9/70A23P10/30A23L29/212A23V2002/00A61K9/48A61K47/36
Inventor 帅放文张诺滋王向峰章家伟
Owner ZHONGSHAN KAIBOSI STARCH MATERIAL TECH
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