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Anti-skin photoaging preparation and application thereof

A skin photoaging and anti-photoaging technology, applied in cosmeceuticals, anti-photoaging skin care products, and royal jelly acid in the field of anti-skin photoaging preparations and cosmetics, can solve the problem of different mechanisms of action, and there is no correlation between royal jelly acid Research reports and other issues to achieve the effect of reducing expression, increasing activity, and inhibiting cell aging

Inactive Publication Date: 2014-01-15
郑锦芬 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, anti-acute radiation and anti-photoaging are completely different concepts, and the mechanism of action of the two is also completely different. Therefore, there is no relevant research report on the anti-photoaging of royal jelly acid.

Method used

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  • Anti-skin photoaging preparation and application thereof
  • Anti-skin photoaging preparation and application thereof
  • Anti-skin photoaging preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1 Anti-photoaging effect of royal jelly acid (10-HDA)

[0039] (1) Human skin fibroblast culture

[0040] Experimental method: Take the foreskin tissue after circumcision of children, separate and obtain purified human fibroblasts, culture the cells in DMEM medium containing 10% special-grade fetal bovine serum (FBS) and penicillin and streptomycin, place at 5% CO 2 cultured in a 37°C incubator.

[0041] (2) UVA irradiation

[0042] Experimental method: when the fibroblasts reach 80%-90% confluence, they are irradiated with UVA. Take the cells out of the incubator, discard the medium, and wash twice with 37°C pre-warmed phosphate buffered saline (PBS). An equal amount of thin layer of PBS was added to each well, and then irradiated with different doses of UVA. Immediately after irradiation, discard the PBS solution, add freshly prepared normal culture medium, and place in 95% humidity, 5% CO 2 cultured in a 37°C incubator. The normal culture medium in thi...

Embodiment 2

[0068] Example 2 Anti-photoaging preparation containing royal jelly acid (10-HDA)

[0069] Mix 10-HDA with emulsifiers such as stearic acid and liquid paraffin to make 10-HDA emulsion. Choose 24 healthy adults, apply the lotion containing 10-HDA or the blank control (without 10-HDA) to two places on the inner side of the right arm, use the lotion three times a day for 15 consecutive days, and use ultraviolet light at the beginning of the experiment The arm was irradiated, once every three days, and twice in total, and the local erythema and pigmentation were observed on the 1st, 3rd, 5th, 7th, 10th, and 15th days after the irradiation.

[0070] The results showed that on the 1st, 3rd, 5th, and 7th day after irradiation, erythema was visible on the skin where the ultraviolet rays were irradiated, and the area and color of the erythema where the 10-HDA emulsion was applied were lighter than those where the blank control was applied. On the 10th and 15th day after irradiation, b...

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Abstract

The invention discloses an anti-skin photoaging preparation containing royal jelly acid (10-HDA), and also discloses application of 10-HDA (10-hydroxy-2-decenoic acid) in preparation of skin care products, cosmetics and cosmeceuticals. The anti-photoaging preparation provided by the invention can significantly improve the activity of UVA (ultra violet A) irradiated cells, inhibit UVA induction produced ROS (reactive oxygen species), inhibit UVA induced cell senescence, and has a significant anti-photoaging effect. Study on the action mechanism of the anti-skin photoaging preparation shows that the 10-HDA contained in the anti-photoaging preparation can inhibit activation of p-JNK and p38 MAPK signaling pathway and reduce UVA induced MMP-1 and MMP-3 expression, thereby increasing the collagen content in cells. Thus, the preparation is an effective anti-skin photoaging preparation.

Description

technical field [0001] This application relates to the field of anti-aging skin preparations, in particular to the application of royal jelly acid in anti-skin photoaging preparations, such as anti-photoaging skin care products, cosmetics, and cosmeceuticals. Background technique [0002] Skin aging mainly includes endogenous aging and exogenous aging. Exogenous aging refers to the aging changes caused by the influence of environmental factors on the skin. It is also called photoaging because it is mainly affected by ultraviolet (Ultraviolet, UV) radiation. Both long-wave ultraviolet (UVA) and medium-wave ultraviolet (UVB) can cause photoaging. Since UVB is 1000 times stronger than UVA in burning the skin, UVB has long been considered the main spectrum that causes photoaging. However, recent studies have shown that UVA is the main spectrum that causes skin photoaging. [0003] The main clinical manifestations of skin photoaging are skin wrinkles, roughness, dryness, relax...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/365A61Q19/08
Inventor 郑锦芬
Owner 郑锦芬
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