One-time target insertion type adjustable light excitation device and tuning method thereof

Abstract

The invention discloses a one-time target insertion type adjustable light excitation device which comprises a light excitation probe, an adjustable light source and a stress signal recording and analyzing module, wherein the emergent end of the light excitation probe is positioned in a target excitation region; the incident end of the light excitation probe is positioned on the outer side of the target excitation region; the adjustable light source is opposite to the incident end of the light excitation probe; the emergent end of the light excitation probe is opposite to a target to be excited in the target excitation region; the stress signal recording and analyzing module is used for detecting the intensity of a target stress signal to be excited. The excitation device can be accurately aligned to the target by tuning the beam shape, the beam width and the target region entry angle of the emergent beam after being inserted in a target region at a time, so that unavoidable space errors in an insertion process are reduced and the light excitation effect is improved. The invention further discloses a tuning method of the one-time target insertion type adjustable light excitation device, and the method is capable of guaranteeing that the excitation device is accurately aligned to the target after being inserted in the target region at a time.

Description

technical field [0001] The invention belongs to the field of optical communication and integrated optics, and in particular relates to a single-insertion target adjustable optical excitation device and a tuning method. Background technique [0002] Optical excitation for micro-specific targets has recently become a cutting-edge technology for the regulation and detection of micron-scale substances. Its applications include but are not limited to: [0003] (1) Optical microstructure imaging such as fluorescence imaging and optical coherence tomography imaging; [0004] (2) Optical tweezers, which use the binding force generated by light beams to control and move micron-sized particles (such as cells); [0005] (3) Optical particle detection, which uses the stress signal of the particle to the optical excitation signal to detect the particle; [0006] (4) Optical neuromodulation, which uses light excitation signals to regulate individual neurons to generate light-induced neu...

AI Technical Summary

Problems solved by technology

However, this design is relatively simple, and it is difficult to adjust the beam shape, beam width, incident angle, etc. of the outgoing beam and achieve precise alignment with the target position

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