Streptomyces toxytricini for high yield of lipstatin and fermentation medium thereof

A technology of Streptomyces toxin and fermentation medium, which is applied in the field of fermentation engineering, can solve the problems of low titer of fermentation products and restrictions on the industrial production of orlistat, and achieve the effect of improving high production capacity and promoting industrial production
CN103555610BInactive Publication Date: 2015-07-22BIOTOOL LLC
2 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
BIOTOOL LLC
Publication Date
2015-07-22
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention provides streptomyces toxytricini for high yield of lipstatin, wherein the streptomyces toxytricini can high-efficiency utilize grease, and has a performance of high yield of lipstatin. On the other hand, the invention further provides an optimized streptomyces toxytricini fermentation medium.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the field of fermentation engineering, and in particular relates to a strain of Streptomyces toxin, which has the performance of high-yielding riprestatin. The invention also relates to a fermentation medium for the strain. Background technique

[0002] Liprestatin is an endogenous lipase inhibitor produced by streptomyces toxytricini, and its tetrahydro derivative orlistat is currently the only weight-loss drug marketed as a non-central nervous system effect [1] . Orlistat has been certified by the FDA and currently occupies 2 / 3 of the weight loss drug market. Orlistat can selectively inhibit the activity of pancreatic lipase in the intestinal tract. As a "fat blocking agent", it only exerts pharmacological effects in the gastrointestinal tract and can prevent about 30% of dietary triglycerides from being digested and absorbed , On the basis of food therapy, calorie intake can be further reduced. Orlistat's high selectivit...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More