Compound levofloxacin hydrochloride liposome and preparation method thereof

A kind of technology of levofloxacin hydrochloride and compound lipid, applied in the field of medicine

Active Publication Date: 2015-05-13
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the dosage forms of levofloxacin hydrochloride on the market in China mainly include common preparations such as tablets, capsules, injections and eye drops, and no new preparations with sustained-release and penetration-enhancing effects have appeared

Method used

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  • Compound levofloxacin hydrochloride liposome and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] This embodiment is the preparation of ebony extract.

[0019] Take 50g of ebony plums, add 250ml of water to soak for 2h, heat to boiling with high heat, then decoct with slow fire for 40min, filter, collect the filtrate, store at 4°C, add 3 times the amount of water to the residue, soak for 2h, decoct for 30min, filter, The two filtrates were combined and spray dried.

Embodiment 2

[0021] The liposome suspension prepared in this example is composed of levofloxacin hydrochloride, phospholipid (soybean lecithin), cholesterol, Span 80, and ebony extract.

[0022] Take 100g of ebony plums and add 500ml of water to soak for 2.5h, heat to boiling with high heat, then decoct with slow fire for 40min, filter, collect the filtrate, store at 4°C, add 3 times the amount of water to the residue, soak for 2h, decoct for 30min, filter, The two filtrates were combined and spray dried.

[0023] Add 2g of levofloxacin hydrochloride, 20g of phospholipid (soybean lecithin), 10g of cholesterol, 80:2g of Span, and 2g of ebony extract into 650ml of ethanol, and perform ultrasonic treatment to fully dissolve until clear; the ethanol solution in which the drug is dissolved is quickly Inject it into an aqueous solution containing 3% ammonium sulfate at 35°C, and at the same time rotate at 500rpm, stir for 3 minutes, the solution is light blue opalescent, and place the dialysis b...

Embodiment 3

[0025] The liposome suspension prepared in this example is composed of levofloxacin hydrochloride, phospholipid (soybean lecithin), cholesterol, Tween 80, and ebony extract.

[0026] Take 200g of ebony plums and add 1000ml of water to soak for 2h, heat to boiling, then decoct with slow fire for 60min, filter, collect the filtrate, store at 4°C, add 3 times the amount of water to the residue, soak for 2h, decoct for 30min, filter and combine 2 filtrates, spray dried.

[0027] Add 2g of levofloxacin hydrochloride, 20g of phospholipid (soybean lecithin), cholesterol, Tween 80: 2g, and 2g of ebony extract into 650ml of ethanol, and perform ultrasonic treatment to fully dissolve until clear; quickly inject the ethanol solution with the drug into the In an aqueous solution containing 3% ammonium sulfate at 35°C, while rotating at 500rpm, stir for 3 minutes, the solution is light blue opalescent, put the dialysis bag containing the solution in a PBS buffer solution with a pH of 7.4 a...

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Abstract

The present invention involves a antibacterial drug hydrochloride hydrochloric acid composite liposome and preparation method. It uses the synergistic effect of levofloxacin hydrochloric acid hydrochloric acid, and the effect of levofloxacin hydrochloride hydrochloride hydrochloride and octumi is significantly enhanced.Neviliated bacteria, the outer outer leaf layer is mainly composed of LPS. The internal liquidity is extremely low. It can effectively exclude some antibiotics. After the hydrochloric acid left oxygen and mixture are made into composite lipids, lipids can effectively effectivelyElberry on the wall of E. coli, destroys the production of the cell wall, invades the outer membrane, and enters the interior of the bacteria by combining with the outer membrane to achieve a better bacteriostatic effect.

Description

technical field [0001] The invention provides a levofloxacin hydrochloride complex liposome, and also discloses a preparation method thereof, which belongs to the technical field of medicine. Background technique [0002] In my country's pharmaceutical market, the sales of anti-infective drugs have always ranked first, with annual sales of about 30 billion yuan, accounting for about 30% of the national pharmaceutical market. Currently, in the anti-infective drug market, quinolones are clinically The consumption of penicillin has surpassed that of penicillin, becoming the second largest antibacterial drug. It is estimated that 1 / 3 of the new antibacterial drug products entering the market are fluoroquinolones. At present, the world's fluoroquinolones are mainly dominated by levofloxacin and ciprofloxacin, and the sum of the two accounts for about 65% of the global sales of fluoroquinolones. Among them, the domestic sales of levofloxacin in 2003 were 1.883 billion yuan. Ranke...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/736A61K9/127A61P31/04A61K31/5383
CPCY02A50/30
Inventor 滕乐生曲娜逯家辉李玉婧彭小君孟庆繁刘艳王贞佐程瑛琨沈畏
Owner JILIN UNIV
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