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Traditional Chinese medicinal preparation for treating damp turbidity and spleen stagnation type hyperlipidemia

A technology for hyperlipidemia, damp turbidity and spleen stagnation, applied to medical preparations containing active ingredients, drug combinations, pharmaceutical formulas, etc., can solve problems such as diabetes, muscle pain, and memory loss

Active Publication Date: 2014-02-19
ZIBO DEV ZONE YADA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But statins have many side effects: they can cause memory loss, diabetes and muscle pain, among others

Method used

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  • Traditional Chinese medicinal preparation for treating damp turbidity and spleen stagnation type hyperlipidemia
  • Traditional Chinese medicinal preparation for treating damp turbidity and spleen stagnation type hyperlipidemia
  • Traditional Chinese medicinal preparation for treating damp turbidity and spleen stagnation type hyperlipidemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0140] Raw material consumption:

[0141] Malt 50kg; Gynostemma 50kg; Yam 20.kg; Chenpi 20kg; Hawthorn 20kg; Ganoderma lucidum 20kg; White lentils 20kg; Jujube 20kg;

[0142] The method is divided into the following steps:

[0143] ⑴All raw materials are mixed according to the proportion, decocted in conventional water, filtered, and the filtrate is the raw medicinal material water extract, which is set aside;

[0144] ⑵Water extract of raw materials and medicinal materials, cooled to room temperature, inoculated with yeast for fermentation;

[0145] ①The strain added is Saccharomyces cerevisiae or Sac.carlsbergensis Hansen),

[0146] ②Proportion of bacteria added

[0147] Raw medicinal material mixed water extract volume: strain weight=100:5;

[0148] ③The fermentation temperature is 20~25℃, and the fermentation time is 30~35h;

[0149] ④End point detection, when the sugar content of the fermentation liquid reaches ≤1°Bx, the fermentation end point is reached;

[0150] ...

Embodiment 2

[0156] Raw material consumption:

[0157] Malt 100kg; Gynostemma 100kg; Yam 50.kg; Chenpi 10kg; Hawthorn 10kg; Ganoderma lucidum 10kg; White lentils 10kg; Jujube 10kg; Yunzhi 10kg and Chixiaodou 10kg.

[0158] In the preparation method, the raw medicinal materials are mixed with the water extract, cooled to room temperature, and yeast is inoculated for fermentation; the added strain is Schizosaccharomyces pombe or Sac.carlsbergensis Hansen); the ratio of the added strain : The volume of decoction of raw medicinal materials mixed with water: strain weight=100:1;

[0159] The fermentation temperature is 25-32°C, and the fermentation time is 40-48 hours; after the suspension fermentation liquid is evaporated and concentrated, the protein content is 43.35%, and it is ground into a fine powder with a particle size of ≤150 μm for later use;

[0160] All the other are with embodiment 1.

Embodiment 3

[0162] Raw material consumption:

[0163] Malt 100kg; Jiaogulan 50kg; Yam 50.kg; Chenpi 15kg; Hawthorn 10kg; Ganoderma lucidum 15kg; White lentils 10kg; Jujube 15kg; Yunzhi 10kg and Chixiaodou 15kg.

[0164] In the production method, raw medicinal materials are mixed with water extract, cooled to room temperature, and yeast is inoculated for fermentation; the added strains are Saccharomyces cerevisiae or Nematospora gossypii; the ratio of strains added: raw medicinal materials Mixed water decoction volume: strain weight = 100:3;

[0165] The fermentation temperature is 24-29°C, and the fermentation time is 36-40 hours; after the suspension fermentation broth is evaporated and concentrated, the protein content is 42.88%, and it is ground into a fine powder with a particle size of ≤150 μm for later use;

[0166] All the other are the same as the embodiment. .

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Abstract

A traditional Chinese medicinal preparation for treating damp turbidity and spleen stagnation type hyperlipidemia is prepared by using malt, millet sprout, rice grain sprout, Gynostemma pentaphylla, lotus leaf, corn silk, Chinese yam, dried orange peel, cassia seed, hawthorn fruit, Mythic Fungus, wolfberry fruit, Poria cocos, white hyacinth bean, lotus seed, black soybean, jujube, Coriolus versicolor(L.ex Fr.)Quel., dahurian angelica root, coix seed, Ligustri Lucidi Fructus and Semen Phaseoli. A preparation method of the traditional Chinese medicinal preparation comprises the following steps: decocting the above raw materials with water, cooling the obtained filtrate to room temperature, and inoculating Saccharomyces cerevisiae or Sac.carlsbergensis Hansen or Schizosaccharomyces pombe or Nematspora gossypii, wherein the amount of the above inoculated bacterium accounts for 1-5% of the volume of the water extract filtrate; fermenting at 20-32DEG C for 30-48h to obtain a suspension fermentation liquid, concentrating to obtain an extract paste, and drying at 80-100DEG C; and grinding the dried extract paste to fine powder having a particle size of 150mum or less to obtain an inactivated thallium and metabolite fine powder, detecting the protein content reaching 40% or more, and filling to a capsule. The clinic cure rate, the significant efficiency, the effective rate and the total effective rate of the preparation are 32.90%, 23.81%, 32.14% and 92.86% respectively.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine preparation for treating hyperlipidemia of damp turbid spleen stagnation type prepared from Chinese medicinal materials, and to a preparation method and application of the composition. Background technique [0002] The invention belongs to the category of pharmaceutical preparations, and in particular relates to a blood lipid-lowering preparation used in the preparation of pharmaceutical preparations for the auxiliary treatment of preventing and treating hyperlipidemia and its technology. [0003] At present, hyperlipidemia is a trend of frequent occurrence, and our country is no exception. [0004] In the prior art, the drugs for treating hyperlipidemia mainly include four categories of clofibrate, niacin, cholestyramine and lovastatin, but all of them have certain toxic and side effects, and many of them have certain damage to the live...

Claims

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Application Information

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IPC IPC(8): A61K36/8998A61K36/8994A61K36/899A61P3/06
Inventor 隋英祝张德伦张林
Owner ZIBO DEV ZONE YADA PHARMA
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