Method for measuring serum metabolism markers in methylamphetamine abusers

A metabolite marker, methamphetamine technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., to achieve the effects of convenient operation, sensitive measurement, and little damage

Inactive Publication Date: 2014-02-26
JIANGSU POLICE INST +1
View PDF1 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the use of metabolomics detection methods

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for measuring serum metabolism markers in methylamphetamine abusers
  • Method for measuring serum metabolism markers in methylamphetamine abusers
  • Method for measuring serum metabolism markers in methylamphetamine abusers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0014] The present invention is explained in detail by the following examples, but it does not mean that the present invention is limited thereto.

[0015] Determination method of serum metabolic markers for rapid diagnosis of methamphetamine abuse

[0016] 1. Experimental Protocol and Sample Collection

[0017] 39 healthy people (23 males, 16 females) and 41 methamphetamine abusers (29 males, 12 females) recorded their gender, age, abuse years, and screened liver and kidney function indicators, including gluten , aspartate, glutamyl, blood urea nitrogen, creatinine, and blood sugar values, and confirmed that they were all within the normal range. Healthy volunteers and methamphetamine abusers collected 1ml of blood on an empty stomach in the morning and put it into a gel tube. After centrifugation at 3500rpm, the supernatant serum was collected and stored at -80°C.

[0018] 2. Sample Processing

[0019] Frozen serum was thawed in a water bath at 37°C for 20 minutes. After ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a method for measuring serum metabolism markers in methylamphetamine abusers. The method mainly utilizes technologies and methods based on gas chromatography mass spectrum (GC-MS) and liquid chromatography mass spectrum (LC-MS) to quantitatively measure the endogenous small molecular compounds in methylamphetamine abusers' blood, then calculates and compares the relative concentration difference of the endogenous small molecular compounds between an abuser group and a normal group, and is used for actual diagnosis of abuse level of methylamphetamine. Compared to other conventional clinical diagnosis indexes, the method has the advantages of wide application area, high sensitivity, convenient sampling, simple operation, and no harm to organisms. The method solves the problem of shortage of clinical indexes for methylamphetamine abusers, and improves the efficiency of detecting methylamphetamine abusers.

Description

technical field [0001] The invention relates to a method for measuring serum metabolic markers of methamphetamine abuse, in particular to the detection of endogenous small molecules in human blood samples by using gas chromatography mass spectrometry and liquid chromatography mass spectrometry, and the determination of methamphetamine abuse suspicion by using relative quantitative or absolute quantitative methods The endogenous small molecules in human serum are compared with the range of small molecule content in normal human serum as the basis for judgment. Background technique [0002] The appearance of methamphetamine is pure white crystals, crystal clear, so it is called "ice" by drug addicts and traffickers. Because it has a strong stimulating effect on the central nervous system of the human body and is highly toxic, it is also called "ice poison". After taking methamphetamine, it will produce strong physiological excitement, which can consume a lot of physical stren...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): G01N30/02G01N30/06
Inventor 王广基阿基业郑天周亚红刘林生
Owner JIANGSU POLICE INST
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap