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A water-soluble base traditional Chinese medicine ointment preparation for treating diabetic foot and its preparation method and application

A water-soluble matrix and diabetic foot technology, which is applied in ointment delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the amputation rate, high mortality rate, high recurrence rate, difficult treatment of diabetic feet, and heavy economic burden for patients To achieve the effect of improving clinical drug use, good adhesion and coating, and controlling the development of gangrene

Active Publication Date: 2016-04-06
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Diabetic foot treatment is difficult, takes a long time, and has a high amputation rate, mortality rate, and recurrence rate, which not only causes physical and mental harm to patients, but also creates a heavy economic burden on society.

Method used

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  • A water-soluble base traditional Chinese medicine ointment preparation for treating diabetic foot and its preparation method and application
  • A water-soluble base traditional Chinese medicine ointment preparation for treating diabetic foot and its preparation method and application
  • A water-soluble base traditional Chinese medicine ointment preparation for treating diabetic foot and its preparation method and application

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Embodiment 1

[0028] The prescription, preparation method and prescription optimization screening method of the water-soluble base Zizhu ointment preparation involved in the present invention are as follows:

[0029] 1 Water-soluble matrix Zizhu ointment prescription medicinal materials and matrix excipients

[0030] Medicinal materials (based on 40g ointment): 1.4g cinnabar, 0.6g comfrey, 1.2g dragon's blood, 0.6g astragalus, 1g donkey-hide gelatin, 0.2g borneol.

[0031] Base excipients (based on 40g ointment volume): poloxamer 4076.8g, poloxamer 1884.8g, water 14g, glycerol (glycerin) 5.2g, polyethylene glycol (PEG) 4001.8g, polyethylene glycol (PEG) 15001.8g, polyethylene glycol (PEG) 40000.6g, ethyl p-hydroxybenzoate 0.012g.

[0032] Among them, 200-mesh water-flying cinnabar is used as an industrial product for cinnabar; donkey-hide gelatin is crushed into 60-mesh powder by electric pulverizer; comfrey and borneol are thermally unstable medicinal materials as active ingredients, whic...

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Abstract

The invention discloses a water-soluble matrix traditional Chinese medicine ointment preparation for treating a diabetic foot, and particularly relates to a water-soluble matrix ointment composed of 6 traditional Chinese medicines, namely roots of redroot gromwell, cinnabar, dragon's blood, membranous milkvetch roots, colla corii asini and borneol, and a specific matrix auxiliary material. In addition, the invention further discloses a preparation technology method and application of the preparation. The external-use traditional Chinese medicine compound ointment preparation provided by the invention can control the progress of the diabetic foot and promote the growth of granulation on a wound surface to enable the gangrene to heal. The ointment is easy to clean and remove, has advantages especially for treatment to an erosion wound surface, plays an absorption effect on percolate and secretion of the diabetic foot, has favorable adhesiveness and coating properties, is uniform in dispersing of all raw materials, stable in quality, favorable in property, appropriate in consistency and suitable for clinical application, can be used for treating the diabetic foot for improving a clinical medication situation, widens an application range of a gromwell and cinnabar ointment, and improves the curative effect.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine and relates to a medicine for treating diabetic foot. Specifically, it relates to an external Chinese medicine water-soluble base ointment preparation capable of controlling the development of diabetic foot gangrene, promoting the growth of sore surface granulation, and healing the gangrene, as well as its preparation method and application. Background technique [0002] Diabetic foot (Diabetic Foot, DF), also known as diabetic acral gangrene, is one of the main chronic complications of diabetes and the main cause of disability in diabetic patients. WHO defines diabetic foot as: lower extremity infection, ulceration and / or destruction of deep tissues in diabetic patients due to neuropathy and various degrees of peripheral vascular disease. The treatment of diabetic foot is difficult, the cycle is long, the amputation rate, mortality rate and recurrence rate are high, which not only cau...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K36/896A61K47/34A61P17/02A61P3/10A61P31/02A61K33/28A61K31/045A61K35/36
Inventor 柳国斌于鑫李西林韩强
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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