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Molecular template and method for producing same
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A technology of molecular template and manufacturing method, which is applied in the analysis of materials, material analysis by optical means, and analysis by chemical reaction of materials, etc. Effect
Inactive Publication Date: 2014-03-26
HITACHI LTD
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Therefore, it is necessary to combine concentration and separation in the measurement, but the measurement method through such a process is just an analysis method in the laboratory, and it is not suitable as a method for the measurement field as described above.
In addition, as mentioned above, in the analysis capability of the current sensor technology, there is a problem that it cannot be technically dealt with
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Embodiment 1
[0077] The molecular template was synthesized by the method shown below using THF (tetrahydrofuran) as a solvent. First, to a mixture of cortisol: itaconic acid: styrene: divinylbenzene (DVB) = 1:4:4:20 (molar ratio), 2% V-70 (2,2'-azobis(4-methoxy-2,4-dimethylvaleronitrile)) as a polymerization initiator.
[0078] Specifically, the polymerization of molecular template polymer (MIP) was carried out according to the formulation in Table 1. Add 362.5mg (1mmol) of cortisol, 524mg (4mmol) of itaconic acid, 418mg (4mmol) of styrene, 2604mg (20mmol) of divinylbenzene (DVB) into a vial, dissolve in THF (20ml ), then move to In a test tube of 18 x 180 mm, 2,2'-azobis(4-methoxy-2,4-dimethylvaleronitrile) (V-70) (0.56 mmol) as a polymerization initiator was dissolved. A septum cap was capped and nitrogen substitution was performed, and polymerization was performed in a 30° C. water bath for 72 hours.
[0079]For a reference experiment, polymerization of a non-molecular template pol...
Embodiment 2
[0092] Methacrylation of Cortisol
[0093] In the above-mentioned Example 1, an example in which MIP was synthesized by utilizing hydrogen bonding between a molecular template raw material such as itaconic acid and cortisol as a template molecule was described. An example of MIP synthesis using a covalent bond between a raw material and a template molecule will be described below. The MIP produced in this Example 2 is called MIP1. First, when synthesizing MIP1, cortisol as a template molecule was converted in the following procedure.
[0094] First, under a nitrogen atmosphere, cortisol (2.5 mmol, 907 mg) was dissolved in dry THF (40 mL), triethylamine (30 mmol, 4.2 ml) was added and ice-cooled. Dry THF (40 mL) in which methacryloyl chloride (15 mmol, 1.5 ml) was dissolved was slowly added dropwise thereto, stirred at 0° C. for 1 hour, and then stirred at room temperature for 4 hours.
[0095] Next, ethyl acetate was added to the reaction liquid, and the organic phase was w...
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Abstract
A method for detecting a chemical and a detection device whereby a chemical is captured by a scavenger and thus detected, said scavenger being produced by using a molecular template. The present invention provides a chemical sensor which is easy-to-use not only for medical experts (e.g., medical doctors, clinical technologists and nurses) but also for general domestic consumers. In particular, the present invention addresses the problem of highly sensitively detecting a steroid hormone such as cortisol, said hormone closely relating to a stress disorder, and thus diagnosing the stress disorder in early stage on the basis of the sign to thereby contribute to the prevention and prompt therapy thereof. Provided is a molecular template of a steroid hormone, said molecular template comprising a polymer capable of interacting with the steroid hormone. The polymer preferably contains, per polymer unit, at least two functional groups that are capable of interacting with the steroid hormone.
Description
technical field [0001] The present invention relates to a molecular template and a manufacturing method thereof, a chemical substance detection device and a chemical substance detection method using the molecular template. Background technique [0002] Chemical substances to be managed in the fields of clinical examination, environment, sanitation, and disaster prevention cover a wide variety of fields and are extremely diverse. Examples include: hormone molecules as markers of stress diseases, endocrine disruptors in environmental hormone problems, soil pollutants in former factory sites, asbestos produced from building materials, and odor-causing substances produced by food, containers or their manufacturing equipment , smelly chemicals, etc. Most of such chemical substances are low-molecular, and are usually contained in extremely small amounts in the measurement objects. However, rapid and highly sensitive detection of these chemical substances is an extremely importan...
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