Production method of N-ethyl-n-butylamine

Abstract

The invention relates to a production method of N-ethyl-n-butylamine. According to the production method, n-butanol and monoethylamine are taken as raw materials; a supported non-noble metal catalyst is used under hydrogen conditions; and amination synthesis of N-ethyl-n-butylamine is performed, wherein a reaction temperature ranges from 120 to 220 DEG C, reaction pressure ranges from 0.1 to 1.2MPa, n-butanol liquid phase airspeed ranges from 0.2 to 1.0h<-1>, and molar ratio of n-butanol to monoethylamine ranges from 0.3 to 1. The supported non-noble metal catalyst used in the production method is a metal active compound-rear earth additive/aluminum oxide supported catalyst, wherein the alumina supporter is alkaline earth metal oxide modified aluminum oxide, the metal active compound comprises at least two selected from copper, cobalt, iron, and zinc; and the additive is a mixture of lanthanum and cerium. Catalyst cost is relatively low; technological processes are reasonable and simple; energy consumption is low; heavy components of byproducts are few; and separation of byproducts is simple.

Description

technical field [0001] The present invention relates to a kind of production method of special amine products, more specifically, the present invention relates to a kind of production method of N-ethyl n-butylamine. technical background [0002] N-Ethyl-n-butylamine (ENBA) is an important organic chemical intermediate, which is the intermediate of the herbicide fenzadi. It is not produced in China at present, and the demand mainly depends on imports. [0003] At present, there are few bibliographical reports on the synthesis method of N-ethyl n-butylamine, which are roughly the N-ethylation method of n-butylamine, the amination method of monoethylamine n-butyraldehyde and the ethylamination method of n-butanol. [0004] The main reagents of N-ethylation method are diethyl sulfate, diethyl phosphate (Phosphorus, Sulfur and Silicon and the Related Elements, 1994, 92 (1-4): 1993-199), ethyl chloride (Journal of Chemical Research, Synopses, 1988, 10: 346-347) or ethanol (Ger.Of...

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Problems solved by technology

[0007] Considering the sources of raw materials, material safety, etc., the n-butanol ethyl amination method is most suitable for industrial production, but the n-butanol ethyl amination method (CN200710071564.4) has only seen patents but no reports of industrial production, and The reactor is a tubular reactor, which is difficult for industrial scale-up and troublesome for equipment fabrication.

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