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A method for identifying malignant pleural effusion

A pleural effusion and property technology, applied in the field of malignant pleural effusion detection, can solve problems such as correlations that have not yet been seen, and achieve the effect of reducing the interference of human subjective factors, good specificity, and high sensitivity

Active Publication Date: 2016-03-02
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no research report on the correlation between CD163 molecule and malignant pleural effusion and its application in identifying malignant pleural effusion

Method used

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  • A method for identifying malignant pleural effusion
  • A method for identifying malignant pleural effusion
  • A method for identifying malignant pleural effusion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0025] In order to test the accuracy of the detection of malignant pleural effusion provided by the present invention, the inventors conducted the following comparative experiments.

[0026] Source of experimental specimens:

[0027] The specimens came from patients in the Department of Oncology and Respiratory Department of the First Affiliated Hospital of Zhengzhou University, a total of 100 cases. Among them, 50 cases of malignant pleural effusion were collected from patients with lung cancer, and 50 cases of inflammatory pleural effusion were collected from patients with inflammation. The pleural effusions of all patients were confirmed by cytological examination of the pathology department. The clinical data and analysis statistics of the patients are shown in the table below. The samples were collected after obtaining the consent of the patients, and an informed consent was signed.

[0028] Clinical data of patients with inflammatory pleural effusion and malignant pleu...

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Abstract

The invention belongs to the technical field of detection methods for malignant pleural effusion, and specifically relates to a method using CD14+? CD163+ cells to identify malignant pleural effusions. The method comprises three steps of extracting mononuclear cells, antibody labeling, and performing immunophenotype analysis by flow cytometry. Compared with the existing technology, this method has the advantages of simplicity, rapidity, high sensitivity, and high specificity; at the same time, this method can reduce the interference of human subjective factors, is more objective, and can make early judgments on patients with potential malignant pleural effusion , identification, so as to provide convenience for subsequent timely intervention and treatment.

Description

technical field [0001] The invention belongs to the technical field of detection methods for malignant pleural effusion, and in particular relates to a method using CD14 + CD163 + A method for cellular identification of malignant pleural effusions. Background technique [0002] Pleural effusion is a common clinical presentation. There are many reasons for pleural effusion, including malignant pleural effusion caused by direct invasion of tumor cells or pleural metastasis caused by bloody diffusion, and other benign causes, such as inflammatory pleural effusion caused by tumor complicated with heart failure, tuberculosis, etc. Effusion. Malignant pleural effusion is a common clinical manifestation of tumor patients, so the judgment of benign and malignant pleural effusion is closely related to treatment and prognosis. [0003] Currently, clinical methods for diagnosing and identifying pleural effusions include clinical manifestations, thoracentesis test results, pleural b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/577
CPCG01N33/57488G01N33/6893G01N2333/535G01N2800/7095
Inventor 张毅王菲
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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