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Alcaftadine for use in treatment of urticaria

A kind of technology of alcaftadine and urticaria, which is applied in the field of application of alcaftadine in the treatment of urticaria, and can solve problems affecting daily life, bad sedation, adverse effects, etc.

Inactive Publication Date: 2014-04-30
ALLERGAN INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Current therapeutic strategies for the management of urticaria can lead to poor sedation, which adversely affects daily life

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0081] A. active agent

[0082] In one embodiment, the active agent is a histamine antagonist (eg, alcaftadine). Histamine antagonists can have multiple targets, e.g., alcaftadine targets H1, H2, and H4 receptors; targets

[0083] Doxepin for H1, H2 and 5HT receptors. In another embodiment, the active agent is at least two

[0084] Combinations of histamine antagonists, which may be directed to the same or different histamine receptors. and if to

[0085] Patients administered a single activator while still achieving the desired therapeutic effect compared to administering a combination of two

[0086] A single composition of different histamine antagonists may allow for lower effective concentrations of each active agent. exist

[0087] In some embodiments, the histamine antagonist is alcaftadine.

[0088] Table 1: Comparison table of histamine antagonists

[0089] histamine antagonist

Product name

dosage

dispensing medicine

Fexofenadine ...

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Abstract

Presented herein inter alia are compositions, methods, and kits for treating an inflammatory skin disorder using a histamine antagonist. In certain embodiments, the compositions, methods, and kits are for treating urticaria and its symptoms. In certain embodiments, the composition, methods, and kits include a topical pharmaceutical preparation with an effective amount of alcaftadine as an active agent.

Description

[0001] Cross References to Related Applications [0002] This application is based upon and claims priority under 35 U.S.C. §120 to U.S. Provisional Patent Application No. 61 / 502,563, filed June 29, 2011, and incorporated herein by reference. Background of the invention [0003] Urticaria, commonly referred to as hives, is a common dermatological disorder that often presents as raised, itchy, well-defined erythematous areas and edema in the dermis and / or epidermis. Acute urticaria afflicts (at some point in its life) 15-20% of the general population in the United States. Globally, the incidence of urticaria is similar to that in the United States. [0004] Hives can be acute (lasting less than 6 weeks) or chronic (lasting more than 6 weeks). Various urticaria variants exist, including acute immunoglobulin E (IGE)-mediated urticaria, chemically induced urticaria (non-IGE-mediated, urticarial vasculitis, autoimmune urticaria, cholinergic Urticaria, cold urticaria, mastocytosi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/55A61P37/08
CPCA61K9/0014A61K31/55A61K9/0009A61P17/00A61P17/04A61P29/00A61P37/08A61P43/00
Inventor D·N·拉勒瓦尼
Owner ALLERGAN INC
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