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Pharmaceutical composition containing water-soluble vitamins for injection, fat-soluble vitamin injection and medium/long-chain fat emulsion injection

A technology of fat-soluble vitamins and water-soluble vitamins, which is applied in the field of medicine and can solve problems such as vitamin deficiency, human health damage, and insufficient synthesis

Inactive Publication Date: 2014-05-07
海南顿斯医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

③ Most of the vitamins cannot be synthesized by the body or the amount of synthesis is insufficient to meet the needs of the body and must be obtained from food frequently
④The human body has very little requirement for vitamins, and the daily requirement is often calculated in milligrams (mg) or micrograms (μg), but once it is deficient, it will cause corresponding vitamin deficiency and cause damage to human health
[0009] However, the common fat emulsion injection used in the pharmaceutical composition in the above-mentioned patent documents has only soybean oil, lecithin and glycerin, which can only provide parenteral nutrition energy and essential fatty acids, and the energy supply is relatively slow. It cannot be used for those patients who lack or reduce the activity of carnitine transport enzyme, and the soybean oil and lecithin are unstable due to the ingredients, and the curative effect is not good

Method used

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  • Pharmaceutical composition containing water-soluble vitamins for injection, fat-soluble vitamin injection and medium/long-chain fat emulsion injection
  • Pharmaceutical composition containing water-soluble vitamins for injection, fat-soluble vitamin injection and medium/long-chain fat emulsion injection
  • Pharmaceutical composition containing water-soluble vitamins for injection, fat-soluble vitamin injection and medium/long-chain fat emulsion injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] Example 1 Preparation of fat-soluble vitamin injection (I)

[0080] (1) Weigh the prescribed amount of vitamin A0.69g, vitamin E6.4g, vitamin D 2 10mg, Vitamin K 10.2g, 1000g of soybean oil for injection, 120g of lecithin for injection, 220g of glycerin, fully stir and mix until the main drug is completely dissolved, then add 9000ml of water for injection, stir well, add water for injection to 10000ml, and stir;

[0081] (2) Use 1mol / L sodium hydroxide solution to adjust the pH value to 7.9, add 3g of activated carbon to stir for adsorption, and filter for decarbonization;

[0082] (3) Fine filtration, filling, 10ml / bottle;

[0083] (4) Sterilize at 121°C for 15 minutes.

Embodiment 2

[0084] Example 2 Preparation of fat-soluble vitamin injection (II)

[0085] (1) Weigh the prescribed amount of vitamin A0.99g, vitamin E9.1g, vitamin D 2 5mg, Vitamin K 1 0.15g, 1000g soybean oil for injection, 120g lecithin for injection, 220g glycerin, stir and mix until the main ingredient is completely dissolved, then add 9000ml of water for injection, stir well, add water for injection to 10000ml, and stir;

[0086] (2) Use 1mol / L sodium hydroxide solution to adjust the pH value to 7.7, add 3g of activated carbon to stir for adsorption, and filter for decarbonization;

[0087] (3) Fine filtration, filling, 10ml / bottle;

[0088] (4) Sterilize at 121°C for 15 minutes.

Embodiment 3

[0089] Example 3 Preparation of Sterile Powder Injection of Water-Soluble Vitamins for Injection

[0090] (1) Weigh vitamin B respectively 1 3.1g, vitamin B 2 4.9g, Niacinamide 40g, Vitamin B 6 4.9g, sodium pantothenate 16.5g, sodium vitamin C 113g, biotin 60mg, folic acid 0.4g, vitamin B125mg, glycine 300g, edetate disodium 0.5g, methyl p-hydroxybenzoate 0.5g, add 2400ml water for injection , stir evenly, adjust the pH value to 6.1 with 1mol / L sodium hydroxide solution or hydrochloric acid solution, completely dissolve the raw and auxiliary materials, add water for injection to 3000ml, add 0.9g of activated carbon for adsorption, and filter for decarbonization;

[0091] (2) Fine filtration, sub-packaging, 3ml / bottle;

[0092] (3) Freeze-drying: a. Pre-freezing: Cool down the subpackaged drug solution to -40 °C at a rate of 2 °C / min, and keep it frozen for 3 hours; b. Sublimation: Vacuumize the pre-frozen drug to 15 Pa , then slowly increase the temperature to -20°C with...

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Abstract

The invention relates to a pharmaceutical composition containing water-soluble vitamins for injection, a fat-soluble vitamin injection and a medium / long-chain fat emulsion injection, particularly a combined applied package, which comprises water-soluble vitamins for injection, a fat-soluble vitamin injection and a medium / long-chain fat emulsion injection. When in use, the water-soluble vitamin aseptic powder injection for injection is dissolved and transferred into the medium / long-chain fat emulsion injection for intravenous infusion. The combined applied package comprehensively supplements vitamins and essential fatty acids required by the human body, avoids the defect due to use of a single vitamin and fatty acid, and greatly enhances the treatment effect.

Description

technical field [0001] The invention relates to a pharmaceutical composition of vitamins and fat emulsions, in particular to a pharmaceutical composition of water-soluble vitamins, fat-soluble vitamin injections and medium / long-chain fat emulsion injections for injection, and belongs to the technical field of medicine. Background technique [0002] Vitamins are a type of trace organic substances necessary for humans and animals to maintain normal physiological functions. They play an important role in the growth, metabolism, and development of the human body. When humans and animals lack vitamins, they cannot grow normally and develop specific lesions. The so-called vitamin deficiency. [0003] Vitamins are also known as vitamins. Generally speaking, they are life-sustaining substances. They are a type of organic substances necessary to maintain human life activities, and are also important active substances to maintain human health. Vitamins are present in small amounts in...

Claims

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Application Information

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IPC IPC(8): A61K36/48A61K31/714A61K31/592A61K9/08A61K9/107A61K9/19A61P3/02
Inventor 王平
Owner 海南顿斯医药科技有限公司
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