Pharmaceutical composition containing water-soluble vitamins for injection, fat-soluble vitamin injection and medium/long-chain fat emulsion injection

A technology of fat-soluble vitamins and water-soluble vitamins, which is applied in the field of medicine and can solve problems such as vitamin deficiency, human health damage, and insufficient synthesis

Inactive Publication Date: 2014-05-07
海南顿斯医药科技有限公司
View PDF5 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

③ Most of the vitamins cannot be synthesized by the body or the amount of synthesis is insufficient to meet the needs of the body and must be obtained from food frequently
④The human body has very little requirement for vitamins, and the daily requirement is often calculated in milligrams (mg) or micrograms (μg), but once it is deficient, it will cause corresponding vitamin deficiency and cause damage to human health
[0009] However, the common fat emulsion

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical composition containing water-soluble vitamins for injection, fat-soluble vitamin injection and medium/long-chain fat emulsion injection
  • Pharmaceutical composition containing water-soluble vitamins for injection, fat-soluble vitamin injection and medium/long-chain fat emulsion injection
  • Pharmaceutical composition containing water-soluble vitamins for injection, fat-soluble vitamin injection and medium/long-chain fat emulsion injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] Example 1 Preparation of fat-soluble vitamin injection (I)

[0080] (1) Weigh the prescribed amount of vitamin A0.69g, vitamin E6.4g, vitamin D 2 10mg, Vitamin K 10.2g, 1000g of soybean oil for injection, 120g of lecithin for injection, 220g of glycerin, fully stir and mix until the main drug is completely dissolved, then add 9000ml of water for injection, stir well, add water for injection to 10000ml, and stir;

[0081] (2) Use 1mol / L sodium hydroxide solution to adjust the pH value to 7.9, add 3g of activated carbon to stir for adsorption, and filter for decarbonization;

[0082] (3) Fine filtration, filling, 10ml / bottle;

[0083] (4) Sterilize at 121°C for 15 minutes.

Embodiment 2

[0084] Example 2 Preparation of fat-soluble vitamin injection (II)

[0085] (1) Weigh the prescribed amount of vitamin A0.99g, vitamin E9.1g, vitamin D 2 5mg, Vitamin K 1 0.15g, 1000g soybean oil for injection, 120g lecithin for injection, 220g glycerin, stir and mix until the main ingredient is completely dissolved, then add 9000ml of water for injection, stir well, add water for injection to 10000ml, and stir;

[0086] (2) Use 1mol / L sodium hydroxide solution to adjust the pH value to 7.7, add 3g of activated carbon to stir for adsorption, and filter for decarbonization;

[0087] (3) Fine filtration, filling, 10ml / bottle;

[0088] (4) Sterilize at 121°C for 15 minutes.

Embodiment 3

[0089] Example 3 Preparation of Sterile Powder Injection of Water-Soluble Vitamins for Injection

[0090] (1) Weigh vitamin B respectively 1 3.1g, vitamin B 2 4.9g, Niacinamide 40g, Vitamin B 6 4.9g, sodium pantothenate 16.5g, sodium vitamin C 113g, biotin 60mg, folic acid 0.4g, vitamin B125mg, glycine 300g, edetate disodium 0.5g, methyl p-hydroxybenzoate 0.5g, add 2400ml water for injection , stir evenly, adjust the pH value to 6.1 with 1mol / L sodium hydroxide solution or hydrochloric acid solution, completely dissolve the raw and auxiliary materials, add water for injection to 3000ml, add 0.9g of activated carbon for adsorption, and filter for decarbonization;

[0091] (2) Fine filtration, sub-packaging, 3ml / bottle;

[0092] (3) Freeze-drying: a. Pre-freezing: Cool down the subpackaged drug solution to -40 °C at a rate of 2 °C / min, and keep it frozen for 3 hours; b. Sublimation: Vacuumize the pre-frozen drug to 15 Pa , then slowly increase the temperature to -20°C with...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a pharmaceutical composition containing water-soluble vitamins for injection, a fat-soluble vitamin injection and a medium/long-chain fat emulsion injection, particularly a combined applied package, which comprises water-soluble vitamins for injection, a fat-soluble vitamin injection and a medium/long-chain fat emulsion injection. When in use, the water-soluble vitamin aseptic powder injection for injection is dissolved and transferred into the medium/long-chain fat emulsion injection for intravenous infusion. The combined applied package comprehensively supplements vitamins and essential fatty acids required by the human body, avoids the defect due to use of a single vitamin and fatty acid, and greatly enhances the treatment effect.

Description

technical field [0001] The invention relates to a pharmaceutical composition of vitamins and fat emulsions, in particular to a pharmaceutical composition of water-soluble vitamins, fat-soluble vitamin injections and medium / long-chain fat emulsion injections for injection, and belongs to the technical field of medicine. Background technique [0002] Vitamins are a type of trace organic substances necessary for humans and animals to maintain normal physiological functions. They play an important role in the growth, metabolism, and development of the human body. When humans and animals lack vitamins, they cannot grow normally and develop specific lesions. The so-called vitamin deficiency. [0003] Vitamins are also known as vitamins. Generally speaking, they are life-sustaining substances. They are a type of organic substances necessary to maintain human life activities, and are also important active substances to maintain human health. Vitamins are present in small amounts in...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K36/48A61K31/714A61K31/592A61K9/08A61K9/107A61K9/19A61P3/02
Inventor 王平
Owner 海南顿斯医药科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap