Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of Danshitongli tablet and application of Danshitongli tablet in preparing drugs for inhibiting Leydig's cell tumor cell MLTC-1 from cell proliferation

The technology of Danshitongli tablets and extraction is applied in the field of preparation of Danshitongli tablets, which can solve the problems of large dosage, many impurities and backwardness of patients, and achieve the effect of reducing the dosage.

Inactive Publication Date: 2014-05-07
JINAN XINQIDIAN MEDICAL TECH
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no gallstone tongli capsule that adopts ultrafine pulverization, CO 2 There are reports on supercritical extraction, microwave technology and macroporous resin adsorption technology. However, the traditional Chinese medicine is directly extracted by powdering and decocted in water. The process is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take. products in clinical application

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take 225g Desmodium, 225g Capillary, 90g Curcuma, 150g Chenpi, 45g Scutellaria, 35g Frankincense, 80g Glauber’s Salt, 35g Alum, 45g Rhubarb, 45g Sanleng, 45g Gardenia, 25g Licorice, 35g Myrrh: Mix Glauber’s Salt, Alum Superfinely pulverize into fine powder with a particle size range of 5-45 μm for later use; take frankincense and myrrh, pulverize into fine powder, and add to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 5%, the extraction pressure is 25MPa, the temperature is 40°C, and the CO 2 The flow rate is 2ml / g crude drug·min, the extraction time is 200min, and the supercritical extract is obtained for use; after extraction, frankincense, myrrh residue and other nine medicinal materials are crushed, added with 3.6L of 70% ethanol, and put into a microwave extraction device for extraction. Microwave extraction, extraction power 700W, extraction 2 times, 8 minutes e...

Embodiment 2

[0034] Take 225g Desmodium, 225g Capillary, 90g Curcuma, 150g Chenpi, 45g Scutellaria, 35g Frankincense, 80g Glauber’s Salt, 35g Alum, 45g Rhubarb, 45g Sanleng, 45g Gardenia, 25g Licorice, 35g Myrrh: Mix Glauber’s Salt, Alum Superfinely pulverize into fine powder with a particle size range of 5-45 μm for later use; take frankincense and myrrh, pulverize into fine powder, and add to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 4%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3ml / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained for later use; the extracted frankincense, myrrh residue and other nine medicinal materials are crushed, and 3.6L of 70% ethanol is added, and put into a microwave extraction device for extraction. Microwave extraction, extraction power 600W, extraction 2 times, 8 minut...

Embodiment 3

[0037] Take 225g Desmodium, 225g Capillary, 90g Curcuma, 150g Chenpi, 45g Scutellaria, 35g Frankincense, 80g Glauber’s Salt, 35g Alum, 45g Rhubarb, 45g Sanleng, 45g Gardenia, 25g Licorice, 35g Myrrh: Mix Glauber’s Salt, Alum Superfinely pulverize into fine powder with a particle size range of 5-45 μm for later use; take frankincense and myrrh, pulverize into fine powder, and add to CO 2In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 6%, the extraction pressure is 15MPa, the temperature is 30°C, and the CO 2 The flow rate is 1ml / g crude drug·min, the extraction time is 220min, and the supercritical extract is obtained for later use; the extracted frankincense, myrrh residue and other nine herbs are crushed, added with 3.6L of 70% ethanol, and put into a microwave extraction device for extraction. Microwave extraction, extraction power 800W, extraction 2 times, 10 minutes each time, co...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly provides a preparation method and application of a Danshitongli tablet. The preparation method comprises the following steps: by using 225g of Herba Lysimachiae, 225g of oriental wormwood, 90g of radix curcumae, 150g of dried orange peel, 45g of radix scutellariae, 35g of frankincense, 80g of mirabilite, 35 of white alum, 45g of rhubarb, 45g of rhizoma sparganii, 45g of gardenia, 25g of licorice and 35g of myrrh as active pharmaceutical ingredients, carrying out superfine grinding, supercritical extraction, microwave extraction and macroporous resin adsorption so that the hesperidin content is greatly enhanced. The invention also provides application of the Danshitongli tablet in preparing drugs for inhibiting Leydig's cell tumor cell MLTC-1 from cell proliferation.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a preparation method of Danshi Tongli Tablet and its application in the preparation of drugs for inhibiting the proliferation of mouse testicular stromal cell tumor cells MLTC-1 cells. Background technique [0002] The standard number of Danshi Tongli Capsules is WS-10324 (ZD-0324)-2002, which is recorded in the Hepatobiliary Subvolume of the National Compilation of Chinese Patent Standards. Made from 225g Desmodium, 225g Capillary, 90g Curcuma, 150g Chenpi, 45g Scutellaria, 35g Frankincense, 80g Glauber’s Salt, 35g Alum, 45g Rhubarb, 45g Sanleng, 45g Gardenia, 25g Licorice, and 35g Myrrh. , has the effect of clearing heat and gallbladder, removing blood stasis and removing stones. For acute and chronic cholecystitis and gallstones caused by damp-heat in the liver and gallbladder. [0003] In the prior art, there is no gallstone tongli capsule ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/20A61P35/00A61K33/04A61K33/06
Inventor 孙波
Owner JINAN XINQIDIAN MEDICAL TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com