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Tablet containing moxonidine hydrochloride and preparation method thereof

A moxonidine hydrochloride and tablet technology, which is applied in the field of pharmaceutical preparations, can solve the problems of poor fluidity, increased drug viscosity, large differences in the content of granules and drugs, and achieves the effects of reducing production costs, simplifying the preparation process, and reducing the types of excipients

Active Publication Date: 2014-06-18
金洪涛
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This new compound has several benefits compared to existing drugs that were previously used for treatments such as anti-inflammatory agents like meflunate (moxynol). It doesn't use extra ingredients but works better than previous methods because it uses less expensive components instead of adding them themselves. Additionally, this drug can be easily prepared without requiring complicated steps involving grinding or milling.

Problems solved by technology

This patented describes two methods used to prepare different types of drugs called oxymorphyrin hydrocinnones or furoxidenhydroreticulators. These techniques have advantages such as ease of manufacturing, consistency between lots, stability over time, etc., while still having some benefits like reducing cardiovascular risk compared to traditional treatments. However, these new formulations may be affected due to their lack of bioavailability caused by reduced absorption from gastrointestinal tract.

Method used

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  • Tablet containing moxonidine hydrochloride and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Moxonidine Hydrochloride 2g

[0030] Macrogol 4000 51g

[0031] Lactose 500g

[0032] Sodium carboxymethyl starch 5g

[0033] Preparation Process:

[0034] Heat polyethylene glycol 4000 to 60°C, melt, add moxonidine hydrochloride to the melt, stir to dissolve, add the melt to the mixed powder of lactose and sodium carboxymethyl starch, granulate, granulate 18 mesh sieve, pressed into tablets.

Embodiment 2

[0036] Moxonidine Hydrochloride 2g

[0037] Macrogol 6000 60g

[0038] Microcrystalline Cellulose 500g

[0039] Crospovidone 6g

[0040] Preparation Process:

[0041] Heat polyethylene glycol 6000 to 70°C, melt, add moxonidine hydrochloride into the molten liquid, stir to dissolve, add the molten liquid to the mixed powder of microcrystalline cellulose and crospovidone, and granulate , the particles are passed through a 20-mesh sieve, and pressed into tablets.

Embodiment 3

[0043] Moxonidine Hydrochloride 2g

[0044] Macrogol 4000 20g

[0045] Macrogol 6000 40g

[0046] Microcrystalline Cellulose 500g

[0047] Crospovidone 6g

[0048] Preparation Process:

[0049] Heat polyethylene glycol 4000 and polyethylene glycol 6000 to 70°C, melt, add moxonidine hydrochloride into the melt, stir to dissolve, add the melt to the mixture of microcrystalline cellulose and crospovidone Mix the powder, granulate, pass the granules through a 20-mesh sieve, and compress into tablets.

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Abstract

The invention discloses a tablet containing moxonidine hydrochloride and a preparation method thereof. The tablet is prepared by virtue of the following steps: dissolving the moxonidine hydrochloride in a polyethylene glycol fused liquid to obtain a solution and pelleting and tableting the solution used as an adhesive on pharmaceutically acceptable auxiliary materials. The tablet disclosed by the invention has the effects of unexpectedly increasing the dissolution rate on the premise of guaranteeing good mixing uniformity of a medicament, simultaneously avoiding addition of a lubricating agent, simplifying the production process and lowering the production cost.

Description

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Claims

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Application Information

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Owner 金洪涛
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