A kind of method that polypropylene glycol and polytrimethylene carbonate improve the flexibility of polypeptide film
A technology of methyl carbonate and polypropylene glycol, applied in the field of polymer film preparation, achieves the effects of simple operation, improved flexibility and easy to master
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Embodiment 1
[0017] 1) Synthesis of Polypeptide Homopolymers Containing Terminal-NCO Groups:
[0018] Add 20 grams of poly(γ-benzyl-L-glutamate) with a molecular weight of 60,000, 0.9 grams of 2,4-toluene diisocyanate and 286 mL of 1,2-dichloroethane solvent into the dry reactor, and add Dibutyltin dilaurate with a total weight of 3‰ of the above-mentioned reactants, under an inert atmosphere, stirred and reacted at 40°C for 40 minutes, terminated the reaction, and used dialysis to remove excess diisocyanate to obtain the target product;
[0019] 2) Synthesis of Polypeptide-Polypropylene Glycol Diblock Copolymer:
[0020] Add 15 g of poly(γ-benzyl-L-glutamate) containing terminal -NCO groups, 11.8 g of polypropylene glycol monobutyl ether with a molecular weight of 3000, and 420 mL of 1,2-dichloroethylene in a dry reactor. an alkane solvent, and then add dibutyltin dilaurate with a total weight of 3‰ of the above-mentioned reactants, under an inert atmosphere, stir and react at 40°C for 5...
Embodiment 2
[0025] 1) Synthesis of Polypeptide Homopolymers Containing Terminal-NCO Groups:
[0026] Add 20 grams of poly(γ-ethyl-L-glutamate) with a molecular weight of 70,000, 1.02 grams of 2,4-toluene diisocyanate and 215 mL of 1,1,2-trichloroethane solvent into the dry reactor, and Add dibutyltin dilaurate with a total weight of 4‰ of the above-mentioned reactants, under an inert atmosphere, stir and react at 45°C for 45 minutes, terminate the reaction, and remove excess diisocyanate by dialysis to obtain the target product;
[0027] 2) Synthesis of Polypeptide-Polypropylene Glycol Diblock Copolymer:
[0028] Add 15 g of poly(γ-ethyl-L-glutamate) containing terminal -NCO groups, 17.1 g of polypropylene glycol monobutyl ether with a molecular weight of 4000, and 410 mL of 1,1,2-trichloro Ethane solvent, and then add dibutyltin dilaurate with a total weight of 4‰ of the above-mentioned reactants, under an inert atmosphere, stir and react at 45°C for 55 minutes, terminate the reaction, ...
Embodiment 3
[0033] 1) Synthesis of Polypeptide Homopolymers Containing Terminal-NCO Groups:
[0034] Add 20 grams of poly(γ-methyl-L-glutamate) with a molecular weight of 80,000, 0.96 grams of 2,4-toluene diisocyanate and 155 mL of 1,2-dichloroethane solvent into the dry reactor, and add the above Dibutyltin dilaurate with a total weight of 5‰ of reactants, under an inert atmosphere, stirred and reacted at 50°C for 50 minutes, terminated the reaction, and used dialysis to remove excess diisocyanate to obtain the target product;
[0035] 2) Synthesis of Polypeptide-Polypropylene Glycol Diblock Copolymer:
[0036] Add 15 g of poly(γ-methyl-L-glutamate) containing terminal -NCO groups, 20.1 g of polypropylene glycol monobutyl ether with a molecular weight of 5000, and 352 mL of 1,2-dichloroethane into a dry reactor Solvent, then add dibutyltin dilaurate with a total weight of 5‰ of the above-mentioned reactants, under an inert atmosphere, stir and react at 50°C for 60 minutes, terminate the...
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