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Medicine for treating headache

The technology of a medicine and a composition is applied in the field of medicine composition for treating headache and its preparation field to achieve the effects of increasing cerebral blood flow, relieving vasospasm and improving microcirculation

Inactive Publication Date: 2014-06-25
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the extraction process and the preparation method of the preparation need to be further optimized

Method used

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  • Medicine for treating headache
  • Medicine for treating headache
  • Medicine for treating headache

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0101] Take Angelica 253.5g, Chuanxiong 253.5g, Paeoniae Alba 202.7g, Rehmannia glutinosa 202.7g, Uncaria 506.8g, Caulis Spatholobus 506.8g, Prunella vulgaris 506.8g, Semen Cassiae 506.8g, Mother of Pearl 506.8g, Corydalis 253.5g, Asarum 50.5g g.

[0102] Preparation of extract 1: take angelica, chuanxiong, corydalis, cassia seed, and white peony, add 4 times the amount of 70% ethanol, heat and reflux to extract twice, the first time for 2 hours, the second time for 1 hour, filter, remove impurities, and recover Ethanol and concentrated to a relative density of 1.300 ~ 1.310 (74 ~ 76 ℃), that is.

[0103] Preparation of extract 2: Take Rehmannia glutinosa, Uncaria, Millae, Prunella vulgaris, mother-of-pearl, and Asarum, add 5 times the amount of water to decoct twice, the first time for 2 hours, the second time for 1 hour, filter , concentrated to a relative density of 1.06-1.10 (80°C), add ethanol to make the alcohol content 65-70%, let stand for 12-24 hours, filter, recover...

Embodiment 2

[0108] Take Angelica 338g, Chuanxiong 338g, Paeoniae Alba 270.3g, Rehmannia glutinosa 270.3g, Uncaria 675.7g, Spatholobus 675.7g, Prunella vulgaris 675.7g, Semen Cassiae 675.7g, Mother of Pearl 675.7g, Corydalis 338g, Asarum 67.3g.

[0109] Preparation of extract 1: take angelica, chuanxiong, corydalis, cassia seed, and white peony, add 3 times the amount of 80% ethanol, heat and reflux for extraction 3 times, the first time for 2 hours, the second and third times for 1 hour each, filter and remove impurities , recover ethanol and concentrate to a relative density of 1.250 to 1.350 (74 to 76 ° C), that is.

[0110] Preparation of extract 2: Take Rehmannia glutinosa, Uncaria, Miltonia, Prunella vulgaris, mother-of-pearl, and Asarum, add 10 times the amount of water to decoct 3 times, the first time for 2 hours, the second and third times for 1 hour each, Filter, concentrate to a relative density of 1.06-1.10 (80°C), add ethanol to make the alcohol content 65-72%, let stand for ...

Embodiment 3

[0114] Take 150g of Angelica, 150g of Chuanxiong, 225g of Radix Paeoniae Alba, 225g of Rehmannia glutinosa, 551g of Uncaria, 551g of Spatholobus, 551g of Prunella vulgaris, 551g of Semen Cassiae, 551g of Mother of Pearl, 225g of Corydalis Corydalis, 19g of Asarum.

[0115] Preparation of extract 1: take Angelica sinensis, Rhizoma Chuanxiong, Corydalis Corydalis, Semen Cassiae, Radix Paeoniae Alba, add 6 times the amount of 50% ethanol, heat and reflux to extract twice, the first time is 2.5 hours, the second time is 1 hour, filter, remove impurities, and recover Ethanol and concentrated to a relative density of 1.250 ~ 1.310 (70 ~ 74 ° C), that is.

[0116] Preparation of extract 2: Take Rehmannia glutinosa, Uncaria, Miltonia, Prunella vulgaris, mother-of-pearl, and Asarum, add 4 times the amount of water to decoct 3 times, the first time is 2.5 hours, the second and third times are 2 hours each, Filter, concentrate to a relative density of 1.06-1.10 (80°C), add ethanol to mak...

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Abstract

The invention discloses a medicine for treating headache, which is prepared by the following steps: adding ethanol into angelica, hemlock parsley, corydalis tuber, cassia seed and white peony root according to parts by weight, extracting by heating under reflux, filtering, removing impurities, recycling ethanol, and concentrating for later use; taking radix rehmanniae preparata, uncaria, spatholobus stem, self-heal, mother-of-pearl and asarum, decocting with water, filtering, concentrating, adding ethanol, standing, filtering, recycling the ethanol, and concentrating for later use; and mixing the two extracts, and adding auxiliary materials to obtain the preparation. The invention also discloses a preparation method of the pharmaceutical composition and application of the pharmaceutical composition in preparing medicines for treating headache, traumatic cerebral nerve syndrome, vertigo, distractedness, insomnia and dreamful sleep.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a pharmaceutical composition for treating headache and a preparation method thereof. Background technique [0002] Headache is a common symptom in daily life, almost everyone will have a headache in their life. There are various causes of headaches. At present, there are many medicines for treating headache at home and abroad, and all of them can only treat symptoms, mainly for pain relief, and seldom adopt surgical treatment, but the effect is not ideal. Drug resistance and addiction are produced, so this type of drug should not be taken for a long time, and it cannot fundamentally solve the headache. In addition, anxiolytics, antidepressants, sympathetic nerve inhibitors, calcium ion blockers, antiepileptic drugs, etc. are clinically used according to different etiologies. These drugs have relatively large side effects, and long-term use will gradually reduce the c...

Claims

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Application Information

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IPC IPC(8): A61K36/804A61P29/00A61P25/00A61P25/20A61K35/56A61K35/618
Inventor 闫希军吴廼峰章顺楠杨建会刘岩邵星云高松董莉娜白晓林孙艳徐波郑永锋范立君
Owner TIANJIN TASLY PHARMA CO LTD