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Pharmaceutical composition for treating nephritic syndrome, as well as preparation method and applications thereof

A technology of nephrotic syndrome and composition, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc. It can solve the problems of uncertain effect, easy recurrence, and large side effects, so as to reduce excretion and improve treatment Effect, low recurrence rate

Inactive Publication Date: 2014-06-25
四川省中医药科学院中医研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The course of RNS is lingering and difficult to heal, and it is prone to recurrent attacks. Many patients are not sensitive to existing immunosuppressants, or are sensitive but relapse after stopping or reducing the dose; however, new immunosuppressants such as MMF used in recent years are expensive, Disadvantages such as uncertain effect and large side effects

Method used

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  • Pharmaceutical composition for treating nephritic syndrome, as well as preparation method and applications thereof
  • Pharmaceutical composition for treating nephritic syndrome, as well as preparation method and applications thereof
  • Pharmaceutical composition for treating nephritic syndrome, as well as preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation of embodiment 1 medicine of the present invention

[0035] 【Prescription】Equisetum 308g, Shiwei 308g, Motherwort 385g, Houttuynia cordata 514g, Hedyotis diffusa 514g, Guanzhong 385g, Scutellaria 308g, Wood Butterfly 308g, Dextrin 20g, Lactose 20g;

[0036] Make 1000 capsules

[0037] [Preparation method] The above eight herbs are added with 6 times the amount of 60% ethanol, refluxed and extracted 3 times, each time for 1 hour, filtered, recovered ethanol, concentrated to a clear paste, added appropriate amount of dextrin and lactose, dried, crushed, and made into granules , dried at 60°C, whole grains, packed into capsules, and made into 1000 grains.

[0038] Instructions: Take three capsules three times a day.

Embodiment 2

[0039] The preparation of embodiment 2 medicines of the present invention

[0040] (1) Weigh the raw materials in the following weight proportions: 340g of horsetail, 440g of Houttuynia cordata, 340g of Hedyotis diffusa, 340g of Hedyotis diffusa, 340g of Shiwei, 340g of Motherwort, 340g of Rhododendron, and 340g of Butterfly.

[0041] (2) Take horsetail and Houttuynia cordata, add water to distill for 3 hours, extract the aromatic water, and collect the aromatic water for later use;

[0042] (3) Step (2) Add the medicinal residues after extracting the aromatic water and Hedyotis diffusa, Hedyotis diffusa, Shiwei, Motherwort, Guanzhong, and Orchard Butterfly for 3 times, combine the decoction, filter, and concentrate the filtrate to relative density For 1.2-1.3 (40-50°C) clear ointment, add ethanol to purify, take supernatant, recover ethanol, add aromatic water prepared in step (2), add purified water, and prepare oral liquid.

Embodiment 3

[0043] The preparation of embodiment 3 medicines of the present invention

[0044] (1) Weigh the raw materials with the following weight proportions: 26g of horsetail, 36g of Houttuynia cordata, 26g of Hedyotis diffusa, 26g of Hedyotis chinensis, 26g of Shiwei, 26g of Motherwort, 26g of Guanzhong, and 26g of Wood Butterfly;

[0045] (2) Directly decocting each raw medicine with water, concentrating, and preparing an oral liquid.

[0046] Prove beneficial effect of the present invention below by specific pharmacodynamics test

[0047] Test drug: the drug of the present invention, prepared according to the method of Example 1, the concentration is 10g crude drug / g extract.

[0048] Main reagents and medicines:

[0049] Prednisone acetate, 5mg / tablet, place of origin: Zhejiang Xianju Pharmaceutical Co., Ltd., batch number: 10944;

[0050] Rubidocin hydrochloride, 10mg / bottle, place of origin: Zhejiang Hisun Pharmaceutical Co., Ltd., batch number 09072B;

[0051] Sterile water f...

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Abstract

The invention discloses a pharmaceutical composition for treating nephritic syndrome. The pharmaceutical composition is a preparation prepared from the following active ingredients in parts by weight: 154-462 parts of herba equiseti hiemalis, 154-462 parts of folium pyrrosiae, 192.5-577.5 parts of herba leonuri, 257-771 parts of houttuynia cordata thunb, 257-771 parts of spreading hedyotis herb, 192.5-577.5 parts of cyrtomium rhizome, 154-462 parts of rhizome dioscoreae hypoglaucae, and 154-462 parts of semen oroxyli. The invention further provides a preparation method and applications of the pharmaceutical composition. The pharmaceutical composition has an effect on improving the kidney function, can obviously reduce excretion of urine protein, improve hypoproteinemia, regulate blood lipid metabolism and improve the pathological injury of a kidney tissue structure, has effects on promoting diuresis, clearing away heat, regulating the immunity function and activating blood for dissolving stasis, has a better treatment effect on nephritic syndrome, and especially refractory nephritic syndrome, and is high in effective rate, obvious in syndrome change and low in recurrence rate, thus having excellent clinical application prospects.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating nephrotic syndrome, its preparation method and application. Background technique [0002] Nephrotic syndrome refers to a group of clinical syndromes characterized by increased permeability of the glomerular basement membrane caused by various etiologies and pathological types, and its typical manifestation is massive proteinuria (>3.5g / day ), hypoalbuminemia (plasma albumin <30g / L), edema or hyperlipidemia, lipiduria and decreased glomerular filtration rate, a syndrome dominated by glomerular lesions. According to the different causes, nephrotic syndrome is traditionally divided into two types: primary and secondary, of which about 75% are caused by primary glomerular diseases, and 25% are secondary glomerular diseases. Diseases, such as systemic lupus erythematosus, diabetes, multiple myeloma nephropathy, amyloidosis and allergic purpura. [0003] Refractory nephrotic syndrome ...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61P13/12A61P7/10A61P29/00A61P37/02
Inventor 吴康衡吴巍
Owner 四川省中医药科学院中医研究所
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