Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of extraction process of andrographolide

A technology of andrographolide and extraction process, applied in the field of medicine, can solve the problems of increasing production cost, difficult to apply industrialized large-scale production, expensive equipment, etc., and achieves the effects of increasing content, being beneficial to health and product safety.

Active Publication Date: 2016-01-20
CHENGDU TONGDE PHARMA
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method uses supercritical extraction and microwave extraction to greatly increase the content, but due to the expensive equipment required for supercritical extraction, microwave treatment, and resin adsorption, the production cost is greatly increased, and it is difficult to apply to large-scale industrial production

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of extraction process of andrographolide
  • A kind of extraction process of andrographolide
  • A kind of extraction process of andrographolide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: a kind of extraction process of andrographolide, it comprises the following steps:

[0034] S1. Pulverize: get the leaf of Andrographis paniculata and dry it naturally, pulverize into a coarse powder with a particle diameter of 20mm, and set aside;

[0035] S2. Extraction: Divide the Andrographis paniculata powder obtained in step S1 into n (n is a positive integer) parts of equal weight, and slowly put them into No. 1 to n extraction tanks for constant temperature extraction, and use the following circulation method for constant temperature extraction:

[0036] No. 1 extraction tank:

[0037] S21. Primary extraction: add 60% ethanol, the addition amount is 3 times the weight of the coarse powder in the extraction tank, soak at a constant temperature of 40°C for 6 hours, and filter to obtain a primary extraction solution;

[0038] S22. Secondary extraction: add 60% ethanol in an amount twice the weight of the coarse powder in the extraction tank, soak at ...

Embodiment 2

[0061] Embodiment 2: a kind of extraction process of andrographolide, it comprises the following steps:

[0062] S1. Pulverize: get the leaf of Andrographis paniculata and dry it naturally, pulverize into a coarse powder with a particle diameter of 18mm, and set aside;

[0063] S2. Leaching: Divide the Andrographis paniculata coarse powder obtained in step S1 into 3 parts of equal weight, slowly drop into No. 1 to No. 3 extraction tanks respectively for constant temperature extraction, and adopt the following circulation mode to carry out constant temperature extraction:

[0064] No. 1 extraction tank:

[0065] S21. Primary extraction: add 80% ethanol, the amount added is 10 times the weight of the coarse powder in the extraction tank, soak at a constant temperature of 50°C for 24 hours, and filter to obtain a primary extraction solution;

[0066] S22. Secondary extraction: add 80% ethanol in an amount 5 times the weight of the coarse powder in the extraction tank, soak at a ...

Embodiment 3

[0084] Embodiment 3: a kind of extraction process of andrographolide, it comprises the following steps:

[0085] S1. Pulverize: get the leaf of Andrographis paniculata and dry it naturally, pulverize into a coarse powder with a particle diameter of 15mm, and set aside;

[0086] S2. Leaching: Divide the Andrographis paniculata coarse powder obtained in step S1 into 5 parts of equal weight, slowly drop into No. 1-5 extraction tanks respectively and carry out constant temperature extraction, and adopt the following circulation mode to carry out constant temperature extraction:

[0087] No. 1 extraction tank:

[0088] S21. Primary extraction: add 92% ethanol in an amount 8 times the weight of the coarse powder in the extraction tank, soak at a constant temperature of 45°C for 15 hours, and filter to obtain a primary extraction solution;

[0089] S22. Secondary extraction: add 92% ethanol in an amount 3 times the weight of the coarse powder in the extraction tank, soak at a consta...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses a process for extracting andrographolide, and belongs to the technical field of medicines. The process comprises the following steps: 1, crushing, namely naturally drying andrographis paniculata leaves in air, and crushing the andrographis paniculata leaves into crude powder with the particle size smaller than 20mm for later use; 2, digesting, namely slowly putting the crude andrographis paniculata powder obtained in the step 1 into an extraction tank for digestion at the constant temperature of 40-50 DEG C, wherein the step of constant-temperature digestion comprises steps of primary digestion, secondary digestion and tertiary digestion; 3, roughly treating, namely decoloring, concentrating and crystallizing; 4, refining, namely dissolving, crystallizing and drying. Compared with a conventional process, the process is high in andrographolide yield, low in residual percentage of the andrographolide in residues, simple to operate, low in equipment cost, low in solvent use amount and beneficial to on-scale industrial production, and the product content is greater than 98%.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a process for extracting andrographolide. Background technique [0002] Andrographis paniculata is the dry aerial part of Andrographis paniculate (Burm.F.) Nees, which is harvested in early autumn when the stems and leaves are luxuriant, and dried in the sun. Andrographis paniculata, also known as spring lotus and autumn willow, is a joy at first sight, Lamicarpa, bitter gall grass, golden vanilla, golden ear hook, Indian grass, bitter grass, etc. It has the effects of clearing away heat and detoxification, reducing inflammation, reducing swelling and relieving pain. It is mainly used to treat bacillary dysentery, urinary tract infection, acute tonsillitis, enteritis, pharyngitis, pneumonia and influenza, etc. It can be used externally to treat sores, furuncles, swollen toxins, and traumatic infections. Mainly produced in Guangdong, Fujian and other provinces, ther...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07D307/60
CPCC07D307/60
Inventor 彭晓华曾永辉范伟川
Owner CHENGDU TONGDE PHARMA