The invention relates to a perilla frutescens lozenge and preparation method thereof. The perilla frutescens lozenge is prepared from following components including, by weight, 1-40 parts of perilla frutescens extracts, 5-30 parts of microcrystalline cellulose, 1-15 parts of citric acid, 5-60 parts of powdered sugar, 0.1-3 parts of a lubricant and a proper amount of a binding agent. The preparation method includes following steps: respectively crushing the perilla frutescens extracts and the auxiliary materials, carrying out a sieving process through an 80-meshes screen, carrying out a uniformly mixing process, preparing a soft material, carrying out a granulating process, carrying out a drying process, carrying out a granule-regulating process and carrying out a tabletting process to obtain the perilla frutescens lozenge. The perilla frutescens lozenge has physiological effects of anti-fatigue, anti-oxidation, anti-complement, blood lipid regulating, anti-tumor, body immunity enhancing and the like.