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Alcohol-free mouthwash

一种无酒精、口腔护理的技术，应用在护理口腔、抗细菌药、药物组合等方向

Inactive Publication Date: 2014-07-02
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Alcohol can be helpful in such compositions because it acts as a solubilizer for many ingredients and it is a flavor enhancer, but as mentioned above, there are disadvantages to oral care products containing alcohol

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] Example 1 - Comparative Composition

[0098] Compositions were prepared with different flavoring oils as follows:

[0099] Table 1 - Mouthwash Compositions

[0100] Element Formulation A (%) Formulation B (%) Sorbitol (70% solution) 5.5 5.5 glycerin 7.5 7.5` Propylene Glycol 7.0 7.0 sodium fluoride 0.05 0.05 cetylpyridinium chloride 0.075 0.075 sodium saccharin 0.022 0.022 Poloxamer 407 0.4 0.4 Spice A 0.12 -- Spice B -- 0.12 Menthol 0.02 0.02 Coolant blend (Optacool?) 0.025 0.025 dye 0.001 0.001 Methylparaben 0.03 0.03 Propylparaben 0.01 0.01 water margin margin

[0101] Table 2 - Flavoring Components

[0102] Element Spice A (%) Spice B (%) L-menthol 20 15 Peppermint Oil -- 9 Spearmint Oil 45 56 synthetic peppermint oil 5 -- Asian Peppermint Oil 10 -- N-ethyl-p-menthane-3-carboxamide 2 ...

Embodiment 2

[0103] Example 2 - Consumer Test

[0104] The compositions described in the previous examples were tested with consumers to measure fragrance preference and purchase intention.

[0105] Table 3 - Consumer Test Results

[0106] Formula A Formula B Purchase intention (definitely will buy-Top Box) 85% 76% I like the taste 87% 80% Gives a lasting freshness 85% 74% Spice Intensity - Loved it 87% 74%

[0107] Generally, the more acceptable composition Formulation A has higher levels of menthol and peppermint oil relative to spearmint oil. Spearmint oil differs from peppermint oil in particular in that peppermint oil has a higher amount of menthol. This difference, combined with higher levels of added menthol, means that formula A has significantly more menthol than formula B

[0108] Without being bound by theory, it is hypothesized that the relatively high level of insoluble menthol in Formula A allows the formation of a spontaneo...

Embodiment 3

[0109] Example 3 - refinement of spices

[0110] Additional fragrances were tested in the above mouthwash compositions and it was confirmed that CPC compositions containing higher levels of insoluble or poorly soluble oils were preferred by consumers. Mouthwashes containing the following flavoring ingredients were consumer tested (ingredients given in weight percent flavor):

[0111] Table 3 - Flavoring Components

[0112] Element Spice C Spice D Spice E Spice F L-menthol 20 43 18 14 N-ethyl-p-menthane-3-carboxamide 7 1 2 1.6 2-Isopropyl-N,2,3-trimethylbutanamide 7 trans anethole 5 6 2 1.6 Eugenol 1 1 Optacool Special C Spice 10 7 Optamint Spice 20 12 BrightStar 7.0 20 Asian Peppermint Oil 10 13 Methyl salicylate 14 14.2 mint spice 3 2.4 Spearmint Blend 12 9.6 L-carvone 33 30 Soft Mint Mix ...

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PUM

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Abstract

The invention provides ethanol-free liquid oral care compositions comprising cetyl pyridinium chloride which do not have an unacceptably bitter taste, e.g. mouthwashes, toothpastes, throat sprays, and breath sprays that are substantially free of ethanol, e.g., comprising (i) an antimicrobially effective amount of cetyl pyridinium chloride (CPC), (ii) one or more flavoring oils which are substantially insoluble in water at room temperature, and (iii) water, wherein the ratio of the CPC to the one or more flavoring oils is from 1:1.5 to 1:2.5, as well as methods of making and using the same.

Description

field of invention [0001] The present invention relates to a compound comprising cetylpyridinium chloride Novel liquid alcohol-free oral care composition. Background of the invention [0002] Traditional mouthwash compositions often contain up to 27% alcohol by volume as a preservative and antimicrobial agent. In some individuals, alcohol can exacerbate xerostomia (dry mouth), which in turn can lead to bad breath and severe tooth decay by reducing the protective effect of saliva to remineralize enamel. Xerostomia also makes the mucous membranes and periodontal tissues of the mouth more susceptible to infection and increases the risk of gingivitis. Mouthwashes containing high levels of alcohol may also be undesirable for use by alcoholics, children, and members of certain religious beliefs, and some consumers may object to the burning sensation of relatively high alcohol compositions. [0003] cetylpyridinium chloride (CPC) is a cationic quaternary ammonium compound c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/34A61K8/41A61K8/92A61Q11/00A61K8/06
CPCA61K2800/30A61Q11/00A61K8/4926A61K8/922A61K8/416A61K2800/5922A61K8/21A61K8/064A61K8/34A61K8/345A61K8/60A61K8/068A61P1/02A61P31/04
Inventor R.富格特K.科尔斯E.S.阿瓦尼蒂多F.佩尔纳
Owner COLGATE PALMOLIVE CO
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