Application of purslane polysaccharide in preparing medicine for preventing or treating liver fibrosis

A technology of purslane polysaccharides and liver fibrosis, applied in the field of medicine, can solve problems such as no literature reports, achieve good therapeutic effect, broaden the application range, and reduce the effect of biochemical indicators

Inactive Publication Date: 2016-05-11
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After systematic research on purslane and combined with the literature, the inventor found that purslane polysaccharide is one of the main material bases of purslane biological activity, but whether purslane polysaccharide has anti-fibrosis effect has not been seen in the literature so far to report

Method used

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  • Application of purslane polysaccharide in preparing medicine for preventing or treating liver fibrosis
  • Application of purslane polysaccharide in preparing medicine for preventing or treating liver fibrosis
  • Application of purslane polysaccharide in preparing medicine for preventing or treating liver fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The preparation of purslane polysaccharide, concrete steps are as follows:

[0017] Method 1: Weigh 2kg of purslane medicinal material, add water equivalent to 10 times the weight of the medicinal material and decoct twice, each time for 2 hours, filter, combine the filtrate, and centrifuge the filtrate at a speed of 3000 rpm for 20 minutes, Collect the supernatant, use the macroporous adsorption resin D101 column activated by the supernatant, and then elute with distilled water equivalent to 5 times the weight of the resin, collect the eluate, and concentrate the eluate to 1 times the weight of the medicinal material , then add ethanol until the volume fraction of ethanol is 65%, refrigerate and stand at 0°C for 12 hours, remove the supernatant, and collect the precipitate; add water equivalent to 3 times the weight of the precipitate to the precipitate, boil for 10 minutes, and place it at room temperature ( 10~30℃), filter, collect the filtrate, add ethanol to the fi...

Embodiment 2

[0021] 1. Anti-hepatic fibrosis effect of purslane polysaccharide

[0022] 1. Experimental animals

[0023] Select Wistar rats weighing 160-180 g, half male and half male. Wistar rats were provided by the Animal Center of the Third Military Medical University of the People's Liberation Army.

[0024] 2. Pathological grading method

[0025] Pathological grading criteria for hepatic steatosis: (-) no vacuolar degeneration in hepatocytes; (+) vacuoles in some hepatocytes (50%).

[0026] Pathological grading criteria of liver cell necrosis: (-) no necrosis of liver cells; (+) point and focal necrosis of liver cells, scattered distribution; (++) point and focal necrosis of liver cells, wide distribution; (+++) Liver cells are in large sheets or bridging necrosis and diffusely distributed.

[0027] Pathological grading standard of liver fibrous tissue hyperplasia: (-) normal liver tissue; (+) increased content of collagen fibers, rarely forming cords to separate liver lobules, e...

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Abstract

The invention discloses applications of portulaca oleracea polysaccharide in preparation of drug for preventing or treating hepatic fibrosis. Animal experimental results show that the portulaca oleracea polysaccharide can obviously reduce the activity of ALT, GPP, LDH and other biochemical indexes in rat serum, relieve degenerative necrosis of hepatic cells, and protect the stability of the hepatic cells, so as to accelerate the proliferation of the hepatic cells, and has excellent anti-hepatic fibrosis effect; in addition, the invention discovers that the portulaca oleracea polysaccharide has the advantages of low toxicity, little side effect and the like, and is safe to use, and can be used for preventing or treating the diseases related to hepatic fibrosis.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of purslane polysaccharide in the preparation of medicines for preventing or treating liver fibrosis. Background technique [0002] Liver fibrosis is a necessary stage for various chronic liver diseases to develop into liver cirrhosis, which can be caused by various pathogenic factors (common causes are viral hepatitis, chronic alcoholism, genetic and metabolic diseases, chemical poisons or drugs, liver congestion, parasites, fatty liver, etc.). Liver fibrosis caused by various liver diseases seriously endangers human health and brings a heavy burden to families and society. Therefore, it is of great social and economic significance to research and develop cheap drugs for the treatment of liver fibrosis. [0003] At present, various measures to eliminate liver fibrosis have their own unsatisfactory effects. In the search for safe and effective anti-hepatic fi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/715A61P1/16
Inventor 林恒孙凤军王显凤
Owner THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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