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Desloratadine syrup and preparation method thereof

A technology of desloratadine and syrup, applied in the field of antiallergic syrup and its preparation

Inactive Publication Date: 2014-10-15
AVENTIS PHARMA HAINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a desloratadine syrup that effectively solves the problem of existing desloratadine stability, and is beneficial to patients with dysphagia to take medicine, and has a simple prescription process and provides a preparation method thereof

Method used

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  • Desloratadine syrup and preparation method thereof
  • Desloratadine syrup and preparation method thereof
  • Desloratadine syrup and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018]

[0019] Preparation:

[0020] Weigh sucrose, add purified water to boil and dissolve, cool to 65-85°C. Add pH regulator, flavoring agent, preservative, colorant to the above solution and stir to dissolve completely, cool to room temperature for later use; Add tadine, stabilizer, and antioxidant to the co-solvent and stir evenly. After mixing evenly, add it to the above-mentioned syrup, continue to stir evenly, filter and add an appropriate amount of boiling water at room temperature to a certain amount to obtain the product.

Embodiment 2

[0022]

Embodiment 3

[0024]

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PUM

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Abstract

Belonging to the technical field of medicine, the invention in particular relates to an antiallergic medicine syrup and a preparation method thereof. The medicinal composition contains desloratadine, a cosolvent, an antioxidant, a pH regulator and other pharmaceutically acceptable excipients. The syrup provided by the invention solves the difficult drug taking problem of patients with weak swallowing ability, and ensures simple process, controllable quality and improved stability, thus bettering meeting clinical needs.

Description

technical field [0001] The invention relates to an antiallergic syrup and a preparation method thereof, in particular to a syrup containing desloratadine. Background technique [0002] Desloratadine is the active metabolite of loratadine, which is a white or off-white solid drug. Desloratadine can play an anti-inflammatory effect by selectively blocking peripheral H1 receptors and inhibiting the release of various allergic inflammatory chemical mediators. It is a non-sedative long-acting tricyclic antihistamine, US Patent US4659716 has done detailed description to this. [0003] Desloratadine is used for rapid relief of symptoms associated with allergic rhinitis, relief of symptoms associated with chronic idiopathic urticaria such as pruritus, and can reduce the number and size of urticaria. [0004] Desloratadine is a primary amine compound, slightly soluble in water, sensitive to acid and oxygen, prone to Maillard reaction or deteriorated by air oxidation. Aiming at the...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/4545A61P37/08
Inventor 王爽任广智黄雪郭夏
Owner AVENTIS PHARMA HAINAN
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