Device for preventing climbing on tail in animal tail suspension test

Abstract

The invention belongs to the field of the biological test instruments and relates to a device for preventing climbing on tail in an animal tail suspension test. The device is capable of preventing an animal from climbing on the tail in an animal tail suspension test. The device is composed of a main suspension arm, a main beam, an upper connecting shaft, a threaded rod, a tension meter, a lifting ring, a suspension arm, a spring plate, semilunar tail climbing preventing plates, a circular ring hook and the like. The height of the tension meter is adjusted by use of a screw on the threaded rod so that the root part of the tail of the animal is slightly lower than the lower parts of the semilunar tail climbing preventing plates. The circular ring hook is fixed to the 1 / 3 part, close to the tail end, of the tail of a mouse by use of an adhesive tape; the semilunar tail climbing preventing plates are divided and stabilized on both sides; the circular ring hook fixed on the tail of the mouse is suspended on a lifting hook. Two semilunar tail climbing preventing plates are connected by use of four connecting fasteners to form a circular structure in the center of which a hole is formed; the tail of the mouse passes through the central round hole and the root part of the tail of the mouse is basically flush with the lower part of the central round hole. The size of the central round hole is smaller than that of the head of the mouse so that the head of the mouse cannot pass through the central round hole and only can contact the root part of the tail of the mouse at top, and therefore, climbing on the tail is prevented.

Description

Technical field: [0001] The invention belongs to the field of biological test instruments and relates to an anti-climbing device for an animal tail suspension test. The function of the invention is to prevent the animal from crawling when the animal tail suspension test is performed. Background technique: [0002] The tail suspension test is one of the most widely used methods for evaluating depressive behavior in rats and mice. Short-term tail suspension is an inescapable stress. From the initial escape behavior of the tail suspension, it will develop into a state of immobility. Various antidepressant drugs can reverse this immobile state and stimulate escape-related behaviors. [0003] The principle of the tail suspension test: When a rat or a mouse hangs upside down, the normal crawling position changes to an uncomfortable upside-down aversion condition position. There will be struggling and trying to escape behaviors such as leaping forward, kicking, trying to raise the head, ...

AI Technical Summary

Problems solved by technology

In the tail-suspension test, if the animal does not move in a hanging state, it represents the negative psychology of the animal in the face of an inescapable situation. When the animal climbs its tail, it represents that the animal has learned to escape, and the method of automatic judgment will automatically change the tail-climbing state. It is also judged to be in a motionless state, and it is impossible to distinguish between the motionless state of the suspension state and the motionless state of the tail climbing state, which affects the experimental results

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