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Intratracheal dosing device for rat

A drug delivery device and intratracheal technology, applied in the field of intratracheal drug delivery devices in rats, can solve problems such as complicated operation and damage, and achieve the effects of convenient operation, less damage and high success rate

Inactive Publication Date: 2014-11-19
天津中医药大学第二附属医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to provide a rat intratracheal drug delivery device, which solves the problem that the existing experimental animal drug delivery method in the trachea is complicated to operate and easily causes damage

Method used

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  • Intratracheal dosing device for rat
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  • Intratracheal dosing device for rat

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Embodiment Construction

[0022] The present invention will be described in detail below in combination with specific embodiments.

[0023] Such as figure 1 As shown, the angle-adjustable console 1 is for fine operation, and the activity of rats may have a greater impact on the experimental results. Moreover, the method of intratracheal administration has become one of the more widely used modeling methods besides tail vein administration. The accuracy of the administration site, the degree of drug dosage control, and the distribution in the lungs have also become factors that affect the experimental results. s reason. Adjustable angle console 1 includes console top 101, console top 101 is movably connected to console support rod 103 through connecting rod 102, and a knob 104 is arranged between connecting rod 102 and support rod 103, and the connecting rod 102 can be adjusted by rotating the knob Angle, the support rod 103 is a telescopic connecting rod, the height of the support rod 103 can be adju...

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Abstract

The invention discloses an intratracheal dosing device for a rat. The intratracheal dosing device for the rat comprises an angle-adjustable operation platform, four legs of the rat are fixed on the angle-adjustable operation platform through elastic fixing clamps, a simple anaesthetic laryngoscope can extend into the mouth of the rat, the mouth of the rat is pulled open by connecting a pull ring to rat teeth, and medicines are injected into the mouth of the rat through an injector. The intratracheal dosing device for the rat has the advantages of being convenient to operate, high in success rate and little in injury.

Description

technical field [0001] The invention belongs to the technical field of animal experiment equipment, and relates to a rat intratracheal drug delivery device. Background technique [0002] With the continuous development of modern medicine, the application of experimental animals in medical research has been continuously valued and promoted. Rats are the most widely used animals in experiments. In addition, the lungs have a large absorption area, the alveolar skin is thin, the lung blood volume is rich, the drug is easily absorbed, and the first-pass effect is avoided. In addition to the lung itself, many systems are increasingly being modeled with intratracheal delivery. [0003] Existing intratracheal administration methods for experimental animals mainly include: tracheotomy, administration under direct vision, blind intubation, inhalation, and the like. Reviewing the previous experimental studies, due to the small size of rats, narrow glottis, and thin trachea, there are...

Claims

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Application Information

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IPC IPC(8): A61D7/00
Inventor 孙增涛刘恩顺祁海燕郑兆晔刘伟郭思佳苏景深关鹏闫博廉富魏葆琳刘二伟封继宏
Owner 天津中医药大学第二附属医院
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