Application of acteoside to preparation of drugs for preventing nerve cell injuries caused by neurotrophic factors (NTFs) and receptors thereof

A technology for nerve cell damage and neurotrophic factors, applied in drug combinations, nervous system diseases, pharmaceutical formulations, etc.

Inactive Publication Date: 2014-11-19
新疆维吾尔自治区维吾尔医药研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006]However, there is currently no literature report or disclosure about the enhancing effect of acteoside on neurotrophic factors and their receptors

Method used

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  • Application of acteoside to preparation of drugs for preventing nerve cell injuries caused by neurotrophic factors (NTFs) and receptors thereof
  • Application of acteoside to preparation of drugs for preventing nerve cell injuries caused by neurotrophic factors (NTFs) and receptors thereof
  • Application of acteoside to preparation of drugs for preventing nerve cell injuries caused by neurotrophic factors (NTFs) and receptors thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Example 1, an application of acteoside-like in the preparation of a drug for protecting nerve cell damage caused by neurotrophic factors and their receptors.

Embodiment 2

[0068] Example 2, as an optimization of the above example, the neurotrophic factor in Example 2 is more than one of NGF, BDNF and NT-3.

Embodiment 3

[0069] Example 3, as an optimization of the above example, the neurotrophic factor receptor in Example 3 is TrkA or / and TrkB.

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PUM

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Abstract

The invention relates to the technical field of neurotrophic factors (NTFs) and in particular relates to an application of acteoside to preparation of drugs for preventing nerve cell injuries caused by the NTFs and receptors thereof. Acteoside can obviously improve the expression of mRNA of NT-3, NGF and BDNF in brain tissues of female Kunming mice in model groups and the receptor TrkB of the BDNF, increase the protein content of the BDNF and TrkB in the brains and reinforce the protein expression levels of NT-3 and the NGF in the cortices and hippocampi of the brain tissues and the receptor TrkA of the NGF, indicating that acteoside has the function of reinforcing the NTFs and the receptors, can alleviate nerve cell injuries caused by reduction of expressions of the NTFs and the receptors thereof and has obviously better effects than vitamin E (VE) groups and piracetam tablet groups.

Description

technical field [0001] The invention relates to the technical field of neurotrophic factors, and relates to the application of acteosides in the preparation of drugs for protecting neurotrophic factors and their receptors from nerve cell damage. Background technique [0002] Neurotrophic factors (neurotrophic factors, NTFs) are a class of polypeptides or proteins produced by the body that can promote the survival, growth and differentiation of nerve cells. They not only regulate the survival of neurons during development, but also activate the activity of enzymes in biochemical and physiological Physiological function, but also prevent the death of adult neurons after injury, promote neuron repair, axon regeneration, regulate synaptic plasticity and neurotransmitter and other nervous system activities. There are five related factors that regulate neurons: nerve growth factor (nerve growth factor, NGF), brain-derived neurotrophic factor (brain-derived neurotrophic factor, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7032A61P25/00
Inventor 闫明高莉彭晓明霍仕霞
Owner 新疆维吾尔自治区维吾尔医药研究所
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