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Eye surface protectant and preparation method thereof

A technology of ocular surface protective agent and vitamin, which is applied in the medical field, can solve problems affecting patient compliance, achieve the effect of reducing ocular surface damage and strong anti-inflammatory effect

Inactive Publication Date: 2016-08-31
NANYANG MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinical observation found that about 40%-60% of patients who used ocular hypotensive drugs for more than 3 years experienced symptoms such as foreign body sensation, burning sensation, dry eyes, tearing, and eyelid discomfort, which significantly affected patients' long-term medication compliance

Method used

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  • Eye surface protectant and preparation method thereof
  • Eye surface protectant and preparation method thereof
  • Eye surface protectant and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] (1) 0.1 parts of vitamin A, 26 parts of vitamin C, 4 parts of vitamin E, 2 parts of reduced glutathione, 150 parts of γ-linolenic acid, 280 parts of linoleic acid, 1.6 parts of zinc gluconate, and 0.16 parts of copper sulfate , 0.33 parts of manganese citrate and 0.01 part of sodium selenite were added to the mortar, ground and stirred for 20 minutes;

[0015] (2) The starch slurry that the massfraction is made into 10% by the method of boiling pulp is cooled to room temperature, and is for subsequent use;

[0016] (3) Add the mixture ground in step 1 to the starch slurry prepared in step 2 by equal incremental method;

[0017] (4) For making soft materials, pass through a 2200um sieve to granulate, dry at 60°C until the moisture content of the dry granules is 1% to 2%; pass through a 2200um sieve for granulation, add talcum powder; adjust the tablet press, and compress to a weight of 200mg Tablets, each containing 50mg of raw material.

[0018] Dosage: 1 tablet / time,...

Embodiment 2

[0020] (1) 0.05 parts of vitamin A, 30 parts of vitamin C, 3 parts of vitamin E, 1 part of reduced glutathione, 145 parts of γ-linolenic acid, 275 parts of linoleic acid, 1.65 parts of zinc gluconate, and 0.15 parts of copper sulfate , 0.35 parts of manganese citrate and 0.015 parts of sodium selenite were added to the mortar, ground and stirred for 20 minutes;

[0021] (2) The starch slurry that the massfraction is made into 10% by the method of boiling pulp is cooled to room temperature, and is for subsequent use;

[0022] (3) Add the mixture ground in step 1 to the starch slurry prepared in step 2 by equal incremental method;

[0023] (4) For making soft materials, pass through a 2200um sieve to granulate, dry at 60°C until the moisture content of the dry granules is 1% to 2%; pass through a 2200um sieve for granulation, add talcum powder; adjust the tablet press, and compress to a weight of 200mg Tablets, each containing 50mg of raw material.

[0024] Dosage: 1 tablet / ti...

Embodiment 3

[0026] (1) 0.15 parts of vitamin A, 25 parts of vitamin C, 5 parts of vitamin E, 3 parts of reduced glutathione, 155 parts of γ-linolenic acid, 285 parts of linoleic acid, 1.55 parts of zinc gluconate, and 0.20 parts of copper sulfate , 0.30 parts of manganese citrate and 0.005 parts of sodium selenite were added into the mortar, ground and stirred for 20 minutes;

[0027] (2) The starch slurry that the massfraction is made into 10% by the method of boiling pulp is cooled to room temperature, and is for subsequent use;

[0028] (3) Add the mixture ground in step 1 to the starch slurry prepared in step 2 by equal incremental method;

[0029] (4) For making soft materials, pass through a 2200um sieve to granulate, dry at 60°C until the moisture content of the dry granules is 1% to 2%; pass through a 2200um sieve for granulation, add talcum powder; adjust the tablet press, and compress to a weight of 200mg Tablets, each containing 50mg of raw material.

[0030] Dosage: 1 tablet...

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Abstract

The invention provides an ocular surface protective agent and a preparation method thereof. The ocular surface protective agent comprises: 0.05-0.15 parts of vitamin A, 25-30 parts of vitamin C, 3-5 parts of vitamin E, and 1-3 parts of reduced glutathione 145-155 parts of γ-linolenic acid, 275-285 parts of linoleic acid, 1.55-1.65 parts of zinc gluconate, 0.15-0.20 parts of copper sulfate, 0.30-0.35 parts of manganese citrate, 0.005-0.015 parts of sodium selenite . The ocular surface protective agent of the invention can effectively reduce the ocular surface damage caused by the use of mild anti-glaucoma drugs.

Description

technical field [0001] The invention relates to the medical field, in particular to an ocular surface protective agent and a preparation method thereof. Background technique [0002] Glaucoma is a lifelong disease that seriously threatens the vision of patients. Long-term topical use of intraocular pressure-lowering drugs is the main method of treatment. Survey results show that among drug-induced ocular surface tissue damage, anti-glaucoma drugs are the most worrisome. Drug-induced ocular surface damage often coexists or is confused with ocular surface diseases, which seriously affects the quality of life of patients and the treatment effect of glaucoma. Long-term use of anti-glaucoma drugs can cause inflammatory reactions, fibrous tissue hyperplasia, keratinization of the conjunctival epithelium, and even angiogenesis and other damage to the conjunctiva. According to clinical observations, about 40%-60% of patients who have used ocular hypotensive drugs for more than 3 y...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/06A61K9/20A61P27/02
Inventor 闫锡秋王爱梅耿若君黄金珠马洁玉李雨鹤侯萍
Owner NANYANG MEDICAL COLLEGE